5E6I

Crystal structure of TCR PF8 in complex with flu MP(58-66) epitope presented by HLA-A2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0005886	cellular_component	plasma membrane
D	0000139	cellular_component	Golgi membrane
D	0002376	biological_process	immune system process
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
D	0002715	biological_process	regulation of natural killer cell mediated immunity
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005765	cellular_component	lysosomal membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005794	cellular_component	Golgi apparatus
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0010038	biological_process	response to metal ion
D	0012507	cellular_component	ER to Golgi transport vesicle membrane
D	0016020	cellular_component	membrane
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0023026	molecular_function	MHC class II protein complex binding
D	0030670	cellular_component	phagocytic vesicle membrane
D	0031901	cellular_component	early endosome membrane
D	0031902	cellular_component	late endosome membrane
D	0031905	cellular_component	early endosome lumen
D	0033572	biological_process	transferrin transport
D	0034756	biological_process	regulation of iron ion transport
D	0034757	biological_process	negative regulation of iron ion transport
D	0035580	cellular_component	specific granule lumen
D	0042605	molecular_function	peptide antigen binding
D	0042612	cellular_component	MHC class I protein complex
D	0042613	cellular_component	MHC class II protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0048261	biological_process	negative regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0050778	biological_process	positive regulation of immune response
D	0050870	biological_process	positive regulation of T cell activation
D	0051289	biological_process	protein homotetramerization
D	0055038	cellular_component	recycling endosome membrane
D	0070062	cellular_component	extracellular exosome
D	0071281	biological_process	cellular response to iron ion
D	0071316	biological_process	cellular response to nicotine
D	1904724	cellular_component	tertiary granule lumen
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation
F	0002250	biological_process	adaptive immune response
F	0002376	biological_process	immune system process
F	0005886	cellular_component	plasma membrane
G	0002250	biological_process	adaptive immune response
G	0002376	biological_process	immune system process
G	0005886	cellular_component	plasma membrane
J	0000139	cellular_component	Golgi membrane
J	0002376	biological_process	immune system process
J	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
J	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
J	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
J	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
J	0002715	biological_process	regulation of natural killer cell mediated immunity
J	0002726	biological_process	positive regulation of T cell cytokine production
J	0005198	molecular_function	structural molecule activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005765	cellular_component	lysosomal membrane
J	0005783	cellular_component	endoplasmic reticulum
J	0005788	cellular_component	endoplasmic reticulum lumen
J	0005794	cellular_component	Golgi apparatus
J	0005886	cellular_component	plasma membrane
J	0005925	cellular_component	focal adhesion
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006955	biological_process	immune response
J	0007608	biological_process	sensory perception of smell
J	0007611	biological_process	learning or memory
J	0009897	cellular_component	external side of plasma membrane
J	0009986	cellular_component	cell surface
J	0010038	biological_process	response to metal ion
J	0012507	cellular_component	ER to Golgi transport vesicle membrane
J	0016020	cellular_component	membrane
J	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
J	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
J	0023026	molecular_function	MHC class II protein complex binding
J	0030670	cellular_component	phagocytic vesicle membrane
J	0031901	cellular_component	early endosome membrane
J	0031902	cellular_component	late endosome membrane
J	0031905	cellular_component	early endosome lumen
J	0033572	biological_process	transferrin transport
J	0034756	biological_process	regulation of iron ion transport
J	0034757	biological_process	negative regulation of iron ion transport
J	0035580	cellular_component	specific granule lumen
J	0042605	molecular_function	peptide antigen binding
J	0042612	cellular_component	MHC class I protein complex
J	0042613	cellular_component	MHC class II protein complex
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0042824	cellular_component	MHC class I peptide loading complex
J	0048260	biological_process	positive regulation of receptor-mediated endocytosis
J	0048261	biological_process	negative regulation of receptor-mediated endocytosis
J	0050680	biological_process	negative regulation of epithelial cell proliferation
J	0050768	biological_process	negative regulation of neurogenesis
J	0050778	biological_process	positive regulation of immune response
J	0050870	biological_process	positive regulation of T cell activation
J	0051289	biological_process	protein homotetramerization
J	0055038	cellular_component	recycling endosome membrane
J	0070062	cellular_component	extracellular exosome
J	0071281	biological_process	cellular response to iron ion
J	0071316	biological_process	cellular response to nicotine
J	1904724	cellular_component	tertiary granule lumen
J	1990000	biological_process	amyloid fibril formation
J	1990712	cellular_component	HFE-transferrin receptor complex
J	2000774	biological_process	positive regulation of cellular senescence
J	2000978	biological_process	negative regulation of forebrain neuron differentiation
N	0000139	cellular_component	Golgi membrane
N	0002376	biological_process	immune system process
N	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
N	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
N	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
N	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
N	0002715	biological_process	regulation of natural killer cell mediated immunity
N	0002726	biological_process	positive regulation of T cell cytokine production
N	0005198	molecular_function	structural molecule activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005765	cellular_component	lysosomal membrane
N	0005783	cellular_component	endoplasmic reticulum
N	0005788	cellular_component	endoplasmic reticulum lumen
N	0005794	cellular_component	Golgi apparatus
N	0005886	cellular_component	plasma membrane
N	0005925	cellular_component	focal adhesion
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006955	biological_process	immune response
N	0007608	biological_process	sensory perception of smell
N	0007611	biological_process	learning or memory
N	0009897	cellular_component	external side of plasma membrane
N	0009986	cellular_component	cell surface
N	0010038	biological_process	response to metal ion
N	0012507	cellular_component	ER to Golgi transport vesicle membrane
N	0016020	cellular_component	membrane
N	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
N	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
N	0023026	molecular_function	MHC class II protein complex binding
N	0030670	cellular_component	phagocytic vesicle membrane
N	0031901	cellular_component	early endosome membrane
N	0031902	cellular_component	late endosome membrane
N	0031905	cellular_component	early endosome lumen
N	0033572	biological_process	transferrin transport
N	0034756	biological_process	regulation of iron ion transport
N	0034757	biological_process	negative regulation of iron ion transport
N	0035580	cellular_component	specific granule lumen
N	0042605	molecular_function	peptide antigen binding
N	0042612	cellular_component	MHC class I protein complex
N	0042613	cellular_component	MHC class II protein complex
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0042824	cellular_component	MHC class I peptide loading complex
N	0048260	biological_process	positive regulation of receptor-mediated endocytosis
N	0048261	biological_process	negative regulation of receptor-mediated endocytosis
N	0050680	biological_process	negative regulation of epithelial cell proliferation
N	0050768	biological_process	negative regulation of neurogenesis
N	0050778	biological_process	positive regulation of immune response
N	0050870	biological_process	positive regulation of T cell activation
N	0051289	biological_process	protein homotetramerization
N	0055038	cellular_component	recycling endosome membrane
N	0070062	cellular_component	extracellular exosome
N	0071281	biological_process	cellular response to iron ion
N	0071316	biological_process	cellular response to nicotine
N	1904724	cellular_component	tertiary granule lumen
N	1990000	biological_process	amyloid fibril formation
N	1990712	cellular_component	HFE-transferrin receptor complex
N	2000774	biological_process	positive regulation of cellular senescence
N	2000978	biological_process	negative regulation of forebrain neuron differentiation
P	0002250	biological_process	adaptive immune response
P	0002376	biological_process	immune system process
P	0005886	cellular_component	plasma membrane
U	0000139	cellular_component	Golgi membrane
U	0002376	biological_process	immune system process
U	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
U	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
U	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
U	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
U	0002715	biological_process	regulation of natural killer cell mediated immunity
U	0002726	biological_process	positive regulation of T cell cytokine production
U	0005198	molecular_function	structural molecule activity
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005615	cellular_component	extracellular space
U	0005765	cellular_component	lysosomal membrane
U	0005783	cellular_component	endoplasmic reticulum
U	0005788	cellular_component	endoplasmic reticulum lumen
U	0005794	cellular_component	Golgi apparatus
U	0005886	cellular_component	plasma membrane
U	0005925	cellular_component	focal adhesion
U	0006879	biological_process	intracellular iron ion homeostasis
U	0006955	biological_process	immune response
U	0007608	biological_process	sensory perception of smell
U	0007611	biological_process	learning or memory
U	0009897	cellular_component	external side of plasma membrane
U	0009986	cellular_component	cell surface
U	0010038	biological_process	response to metal ion
U	0012507	cellular_component	ER to Golgi transport vesicle membrane
U	0016020	cellular_component	membrane
U	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
U	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
U	0023026	molecular_function	MHC class II protein complex binding
U	0030670	cellular_component	phagocytic vesicle membrane
U	0031901	cellular_component	early endosome membrane
U	0031902	cellular_component	late endosome membrane
U	0031905	cellular_component	early endosome lumen
U	0033572	biological_process	transferrin transport
U	0034756	biological_process	regulation of iron ion transport
U	0034757	biological_process	negative regulation of iron ion transport
U	0035580	cellular_component	specific granule lumen
U	0042605	molecular_function	peptide antigen binding
U	0042612	cellular_component	MHC class I protein complex
U	0042613	cellular_component	MHC class II protein complex
U	0042802	molecular_function	identical protein binding
U	0042803	molecular_function	protein homodimerization activity
U	0042824	cellular_component	MHC class I peptide loading complex
U	0048260	biological_process	positive regulation of receptor-mediated endocytosis
U	0048261	biological_process	negative regulation of receptor-mediated endocytosis
U	0050680	biological_process	negative regulation of epithelial cell proliferation
U	0050768	biological_process	negative regulation of neurogenesis
U	0050778	biological_process	positive regulation of immune response
U	0050870	biological_process	positive regulation of T cell activation
U	0051289	biological_process	protein homotetramerization
U	0055038	cellular_component	recycling endosome membrane
U	0070062	cellular_component	extracellular exosome
U	0071281	biological_process	cellular response to iron ion
U	0071316	biological_process	cellular response to nicotine
U	1904724	cellular_component	tertiary granule lumen
U	1990000	biological_process	amyloid fibril formation
U	1990712	cellular_component	HFE-transferrin receptor complex
U	2000774	biological_process	positive regulation of cellular senescence
U	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
J	TYR78-HIS84
I	TYR257-HIS263

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	89
Details	Region: {"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	364
Details	Region: {"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21943705","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21543847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	176
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---