5E6I

Crystal structure of TCR PF8 in complex with flu MP(58-66) epitope presented by HLA-A2

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0000139	cellular_component	Golgi membrane
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005765	cellular_component	lysosomal membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0010977	biological_process	negative regulation of neuron projection development
D	0012507	cellular_component	ER to Golgi transport vesicle membrane
D	0016020	cellular_component	membrane
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0023026	molecular_function	MHC class II protein complex binding
D	0030670	cellular_component	phagocytic vesicle membrane
D	0031901	cellular_component	early endosome membrane
D	0031902	cellular_component	late endosome membrane
D	0031905	cellular_component	early endosome lumen
D	0032092	biological_process	positive regulation of protein binding
D	0033077	biological_process	T cell differentiation in thymus
D	0034756	biological_process	regulation of iron ion transport
D	0035580	cellular_component	specific granule lumen
D	0042026	biological_process	protein refolding
D	0042605	molecular_function	peptide antigen binding
D	0042612	cellular_component	MHC class I protein complex
D	0042613	cellular_component	MHC class II protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0050778	biological_process	positive regulation of immune response
D	0050870	biological_process	positive regulation of T cell activation
D	0051289	biological_process	protein homotetramerization
D	0055038	cellular_component	recycling endosome membrane
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0070062	cellular_component	extracellular exosome
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1900121	biological_process	negative regulation of receptor binding
D	1900122	biological_process	positive regulation of receptor binding
D	1904434	biological_process	positive regulation of ferrous iron binding
D	1904437	biological_process	positive regulation of transferrin receptor binding
D	1904724	cellular_component	tertiary granule lumen
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation
J	0000139	cellular_component	Golgi membrane
J	0001913	biological_process	T cell mediated cytotoxicity
J	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
J	0002237	biological_process	response to molecule of bacterial origin
J	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
J	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
J	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
J	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
J	0002726	biological_process	positive regulation of T cell cytokine production
J	0005198	molecular_function	structural molecule activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005765	cellular_component	lysosomal membrane
J	0005783	cellular_component	endoplasmic reticulum
J	0005788	cellular_component	endoplasmic reticulum lumen
J	0005794	cellular_component	Golgi apparatus
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0005925	cellular_component	focal adhesion
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006955	biological_process	immune response
J	0007608	biological_process	sensory perception of smell
J	0007611	biological_process	learning or memory
J	0009897	cellular_component	external side of plasma membrane
J	0009986	cellular_component	cell surface
J	0010977	biological_process	negative regulation of neuron projection development
J	0012507	cellular_component	ER to Golgi transport vesicle membrane
J	0016020	cellular_component	membrane
J	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
J	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
J	0023026	molecular_function	MHC class II protein complex binding
J	0030670	cellular_component	phagocytic vesicle membrane
J	0031901	cellular_component	early endosome membrane
J	0031902	cellular_component	late endosome membrane
J	0031905	cellular_component	early endosome lumen
J	0032092	biological_process	positive regulation of protein binding
J	0033077	biological_process	T cell differentiation in thymus
J	0034756	biological_process	regulation of iron ion transport
J	0035580	cellular_component	specific granule lumen
J	0042026	biological_process	protein refolding
J	0042605	molecular_function	peptide antigen binding
J	0042612	cellular_component	MHC class I protein complex
J	0042613	cellular_component	MHC class II protein complex
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0042824	cellular_component	MHC class I peptide loading complex
J	0045646	biological_process	regulation of erythrocyte differentiation
J	0048260	biological_process	positive regulation of receptor-mediated endocytosis
J	0050680	biological_process	negative regulation of epithelial cell proliferation
J	0050768	biological_process	negative regulation of neurogenesis
J	0050778	biological_process	positive regulation of immune response
J	0050870	biological_process	positive regulation of T cell activation
J	0051289	biological_process	protein homotetramerization
J	0055038	cellular_component	recycling endosome membrane
J	0060586	biological_process	multicellular organismal-level iron ion homeostasis
J	0070062	cellular_component	extracellular exosome
J	0071281	biological_process	cellular response to iron ion
J	0071283	biological_process	cellular response to iron(III) ion
J	0071316	biological_process	cellular response to nicotine
J	1900121	biological_process	negative regulation of receptor binding
J	1900122	biological_process	positive regulation of receptor binding
J	1904434	biological_process	positive regulation of ferrous iron binding
J	1904437	biological_process	positive regulation of transferrin receptor binding
J	1904724	cellular_component	tertiary granule lumen
J	1990000	biological_process	amyloid fibril formation
J	1990712	cellular_component	HFE-transferrin receptor complex
J	2000774	biological_process	positive regulation of cellular senescence
J	2000978	biological_process	negative regulation of forebrain neuron differentiation
N	0000139	cellular_component	Golgi membrane
N	0001913	biological_process	T cell mediated cytotoxicity
N	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
N	0002237	biological_process	response to molecule of bacterial origin
N	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
N	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
N	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
N	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
N	0002726	biological_process	positive regulation of T cell cytokine production
N	0005198	molecular_function	structural molecule activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005765	cellular_component	lysosomal membrane
N	0005783	cellular_component	endoplasmic reticulum
N	0005788	cellular_component	endoplasmic reticulum lumen
N	0005794	cellular_component	Golgi apparatus
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0005925	cellular_component	focal adhesion
N	0006826	biological_process	iron ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006955	biological_process	immune response
N	0007608	biological_process	sensory perception of smell
N	0007611	biological_process	learning or memory
N	0009897	cellular_component	external side of plasma membrane
N	0009986	cellular_component	cell surface
N	0010977	biological_process	negative regulation of neuron projection development
N	0012507	cellular_component	ER to Golgi transport vesicle membrane
N	0016020	cellular_component	membrane
N	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
N	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
N	0023026	molecular_function	MHC class II protein complex binding
N	0030670	cellular_component	phagocytic vesicle membrane
N	0031901	cellular_component	early endosome membrane
N	0031902	cellular_component	late endosome membrane
N	0031905	cellular_component	early endosome lumen
N	0032092	biological_process	positive regulation of protein binding
N	0033077	biological_process	T cell differentiation in thymus
N	0034756	biological_process	regulation of iron ion transport
N	0035580	cellular_component	specific granule lumen
N	0042026	biological_process	protein refolding
N	0042605	molecular_function	peptide antigen binding
N	0042612	cellular_component	MHC class I protein complex
N	0042613	cellular_component	MHC class II protein complex
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0042824	cellular_component	MHC class I peptide loading complex
N	0045646	biological_process	regulation of erythrocyte differentiation
N	0048260	biological_process	positive regulation of receptor-mediated endocytosis
N	0050680	biological_process	negative regulation of epithelial cell proliferation
N	0050768	biological_process	negative regulation of neurogenesis
N	0050778	biological_process	positive regulation of immune response
N	0050870	biological_process	positive regulation of T cell activation
N	0051289	biological_process	protein homotetramerization
N	0055038	cellular_component	recycling endosome membrane
N	0060586	biological_process	multicellular organismal-level iron ion homeostasis
N	0070062	cellular_component	extracellular exosome
N	0071281	biological_process	cellular response to iron ion
N	0071283	biological_process	cellular response to iron(III) ion
N	0071316	biological_process	cellular response to nicotine
N	1900121	biological_process	negative regulation of receptor binding
N	1900122	biological_process	positive regulation of receptor binding
N	1904434	biological_process	positive regulation of ferrous iron binding
N	1904437	biological_process	positive regulation of transferrin receptor binding
N	1904724	cellular_component	tertiary granule lumen
N	1990000	biological_process	amyloid fibril formation
N	1990712	cellular_component	HFE-transferrin receptor complex
N	2000774	biological_process	positive regulation of cellular senescence
N	2000978	biological_process	negative regulation of forebrain neuron differentiation
U	0000139	cellular_component	Golgi membrane
U	0001913	biological_process	T cell mediated cytotoxicity
U	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
U	0002237	biological_process	response to molecule of bacterial origin
U	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
U	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
U	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
U	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
U	0002726	biological_process	positive regulation of T cell cytokine production
U	0005198	molecular_function	structural molecule activity
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005615	cellular_component	extracellular space
U	0005765	cellular_component	lysosomal membrane
U	0005783	cellular_component	endoplasmic reticulum
U	0005788	cellular_component	endoplasmic reticulum lumen
U	0005794	cellular_component	Golgi apparatus
U	0005829	cellular_component	cytosol
U	0005886	cellular_component	plasma membrane
U	0005925	cellular_component	focal adhesion
U	0006826	biological_process	iron ion transport
U	0006879	biological_process	intracellular iron ion homeostasis
U	0006955	biological_process	immune response
U	0007608	biological_process	sensory perception of smell
U	0007611	biological_process	learning or memory
U	0009897	cellular_component	external side of plasma membrane
U	0009986	cellular_component	cell surface
U	0010977	biological_process	negative regulation of neuron projection development
U	0012507	cellular_component	ER to Golgi transport vesicle membrane
U	0016020	cellular_component	membrane
U	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
U	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
U	0023026	molecular_function	MHC class II protein complex binding
U	0030670	cellular_component	phagocytic vesicle membrane
U	0031901	cellular_component	early endosome membrane
U	0031902	cellular_component	late endosome membrane
U	0031905	cellular_component	early endosome lumen
U	0032092	biological_process	positive regulation of protein binding
U	0033077	biological_process	T cell differentiation in thymus
U	0034756	biological_process	regulation of iron ion transport
U	0035580	cellular_component	specific granule lumen
U	0042026	biological_process	protein refolding
U	0042605	molecular_function	peptide antigen binding
U	0042612	cellular_component	MHC class I protein complex
U	0042613	cellular_component	MHC class II protein complex
U	0042802	molecular_function	identical protein binding
U	0042803	molecular_function	protein homodimerization activity
U	0042824	cellular_component	MHC class I peptide loading complex
U	0045646	biological_process	regulation of erythrocyte differentiation
U	0048260	biological_process	positive regulation of receptor-mediated endocytosis
U	0050680	biological_process	negative regulation of epithelial cell proliferation
U	0050768	biological_process	negative regulation of neurogenesis
U	0050778	biological_process	positive regulation of immune response
U	0050870	biological_process	positive regulation of T cell activation
U	0051289	biological_process	protein homotetramerization
U	0055038	cellular_component	recycling endosome membrane
U	0060586	biological_process	multicellular organismal-level iron ion homeostasis
U	0070062	cellular_component	extracellular exosome
U	0071281	biological_process	cellular response to iron ion
U	0071283	biological_process	cellular response to iron(III) ion
U	0071316	biological_process	cellular response to nicotine
U	1900121	biological_process	negative regulation of receptor binding
U	1900122	biological_process	positive regulation of receptor binding
U	1904434	biological_process	positive regulation of ferrous iron binding
U	1904437	biological_process	positive regulation of transferrin receptor binding
U	1904724	cellular_component	tertiary granule lumen
U	1990000	biological_process	amyloid fibril formation
U	1990712	cellular_component	HFE-transferrin receptor complex
U	2000774	biological_process	positive regulation of cellular senescence
U	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
J	TYR78-HIS84
I	TYR257-HIS263

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280

Chain	Residue	Details
J	GLN2
C	THR143
C	LYS146
C	TYR171
M	TYR7
M	THR73
M	TYR84
M	THR143
M	LYS146
M	TYR171
R	TYR7
D	GLN2
R	THR73
R	TYR84
R	THR143
R	LYS146
R	TYR171
N	GLN2
U	GLN2
I	LYS146
I	TYR171
C	TYR7
C	THR73
C	TYR84

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443

Chain	Residue	Details
J	ILE1
D	ILE1
N	ILE1
U	ILE1
M	TYR116
M	TYR159
R	TYR116
R	TYR159

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443

Chain	Residue	Details
J	LYS19
D	LYS58
D	LYS91
D	LYS94
N	LYS19
N	LYS41
N	LYS48
N	LYS58
N	LYS91
N	LYS94
U	LYS19
J	LYS41
U	LYS41
U	LYS48
U	LYS58
U	LYS91
U	LYS94
J	LYS48
J	LYS58
J	LYS91
J	LYS94
D	LYS19
D	LYS41
D	LYS48

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
I	ASN86
C	ASN86
M	ASN86
R	ASN86

---