5E6H
A Linked Jumonji Domain of the KDM5A Lysine Demethylase
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 601 |
| Chain | Residue |
| A | HIS483 |
| A | GLU485 |
| A | HIS571 |
| A | AKG602 |
| A | HOH728 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue AKG A 602 |
| Chain | Residue |
| A | GLU485 |
| A | SER491 |
| A | ASN493 |
| A | LYS501 |
| A | TRP503 |
| A | HIS571 |
| A | ALA583 |
| A | MN601 |
| A | HOH724 |
| A | HOH728 |
| A | TYR409 |
| A | TYR472 |
| A | PHE480 |
| A | HIS483 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | LEU80 |
| A | GLU81 |
| A | SER399 |
| A | ILE539 |
| A | MET540 |
| A | ASN541 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | ALA357 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 50 |
| Details | ZN_FING: PHD-type 1 => ECO:0000255|PROSITE-ProRule:PRU00146 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:27427228 |
| Chain | Residue | Details |
| A | TYR409 | |
| A | SER491 | |
| A | ASN493 | |
| A | LYS501 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454 |
| Chain | Residue | Details |
| A | HIS483 | |
| A | HIS571 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454 |
| Chain | Residue | Details |
| A | GLU485 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER464 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LEU451 |
