5E5H
Succinyl-CoA:acetate CoA-transferase (AarCH6) bound to acetate and degradation products from the acetyl-CoA analogue dethiaacetyl-CoA
Replaces: 4FACFunctional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003986 | molecular_function | acetyl-CoA hydrolase activity |
A | 0006083 | biological_process | acetate metabolic process |
A | 0006084 | biological_process | acetyl-CoA metabolic process |
A | 0006085 | biological_process | acetyl-CoA biosynthetic process |
A | 0008410 | molecular_function | CoA-transferase activity |
A | 0008775 | molecular_function | acetate CoA-transferase activity |
A | 0016740 | molecular_function | transferase activity |
A | 0019427 | biological_process | acetyl-CoA biosynthetic process from acetate |
A | 0045733 | biological_process | acetate catabolic process |
A | 1901289 | biological_process | succinyl-CoA catabolic process |
B | 0003986 | molecular_function | acetyl-CoA hydrolase activity |
B | 0006083 | biological_process | acetate metabolic process |
B | 0006084 | biological_process | acetyl-CoA metabolic process |
B | 0006085 | biological_process | acetyl-CoA biosynthetic process |
B | 0008410 | molecular_function | CoA-transferase activity |
B | 0008775 | molecular_function | acetate CoA-transferase activity |
B | 0016740 | molecular_function | transferase activity |
B | 0019427 | biological_process | acetyl-CoA biosynthetic process from acetate |
B | 0045733 | biological_process | acetate catabolic process |
B | 1901289 | biological_process | succinyl-CoA catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue CL A 601 |
Chain | Residue |
A | ASN112 |
A | ARG120 |
A | ASN125 |
B | GLY443 |
B | HOH956 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue CL A 602 |
Chain | Residue |
A | VAL196 |
A | ARG354 |
A | HOH854 |
B | ARG354 |
site_id | AC3 |
Number of Residues | 25 |
Details | binding site for residue 0T1 A 603 |
Chain | Residue |
A | GLU294 |
A | ASN361 |
A | GLY362 |
A | MET363 |
A | ILE364 |
A | SER374 |
A | MET383 |
A | ASN384 |
A | GLY385 |
A | ILE386 |
A | SER389 |
A | ALA407 |
A | ILE412 |
A | ACE604 |
A | HOH707 |
A | HOH718 |
A | HOH743 |
A | HOH758 |
A | HOH772 |
A | HOH782 |
A | HOH817 |
A | HOH820 |
A | HOH839 |
A | HOH879 |
A | HOH915 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue ACE A 604 |
Chain | Residue |
A | PHE92 |
A | LEU114 |
A | GLU294 |
A | GLY387 |
A | GLY388 |
A | 0T1603 |
A | HOH802 |
site_id | AC5 |
Number of Residues | 1 |
Details | binding site for residue FMT A 605 |
Chain | Residue |
A | ASP202 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue IMD A 606 |
Chain | Residue |
A | ALA419 |
B | MET418 |
B | ALA419 |
B | HOH712 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue IMD A 607 |
Chain | Residue |
A | THR487 |
A | LEU490 |
A | SER491 |
A | GLN494 |
A | HOH829 |
B | LEU486 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue CL B 601 |
Chain | Residue |
A | GLY443 |
B | ARG120 |
B | ASN125 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue CL B 602 |
Chain | Residue |
A | ARG354 |
B | VAL196 |
B | ARG354 |
B | HOH852 |
site_id | AD1 |
Number of Residues | 27 |
Details | binding site for residue 0T1 B 603 |
Chain | Residue |
B | GLY269 |
B | VAL270 |
B | GLY271 |
B | ASN272 |
B | VAL273 |
B | GLU294 |
B | ASN361 |
B | MET363 |
B | ILE364 |
B | SER374 |
B | ASN384 |
B | GLY385 |
B | ILE386 |
B | SER389 |
B | ALA407 |
B | LYS408 |
B | ILE412 |
B | HOH726 |
B | HOH735 |
B | HOH769 |
B | HOH783 |
B | HOH786 |
B | HOH853 |
B | HOH867 |
B | HOH912 |
B | HOH917 |
B | HOH919 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue ACT B 604 |
Chain | Residue |
B | THR36 |
B | SER71 |
B | THR94 |
B | ARG228 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue IMD B 605 |
Chain | Residue |
A | VAL190 |
B | ARG258 |
B | PRO260 |
B | TYR397 |
site_id | AD4 |
Number of Residues | 7 |
Details | binding site for residue IMD B 606 |
Chain | Residue |
B | HOH833 |
B | HOH864 |
A | LEU486 |
B | THR487 |
B | LEU490 |
B | SER491 |
B | GLN494 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: 5-glutamyl coenzyme A thioester intermediate => ECO:0000269|PubMed:23030530 |
Chain | Residue | Details |
A | GLU294 | |
B | GLU294 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23030530 |
Chain | Residue | Details |
A | GLY269 | |
B | LYS408 | |
A | ILE364 | |
A | ASN384 | |
A | GLY388 | |
A | LYS408 | |
B | GLY269 | |
B | ILE364 | |
B | ASN384 | |
B | GLY388 |