5E5H
Succinyl-CoA:acetate CoA-transferase (AarCH6) bound to acetate and degradation products from the acetyl-CoA analogue dethiaacetyl-CoA
Replaces: 4FACFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003986 | molecular_function | acetyl-CoA hydrolase activity |
| A | 0006083 | biological_process | acetate metabolic process |
| A | 0006084 | biological_process | acetyl-CoA metabolic process |
| A | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| A | 0008410 | molecular_function | CoA-transferase activity |
| A | 0008775 | molecular_function | acetate CoA-transferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019427 | biological_process | acetyl-CoA biosynthetic process from acetate |
| A | 0045733 | biological_process | acetate catabolic process |
| A | 1901289 | biological_process | succinyl-CoA catabolic process |
| B | 0003986 | molecular_function | acetyl-CoA hydrolase activity |
| B | 0006083 | biological_process | acetate metabolic process |
| B | 0006084 | biological_process | acetyl-CoA metabolic process |
| B | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| B | 0008410 | molecular_function | CoA-transferase activity |
| B | 0008775 | molecular_function | acetate CoA-transferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019427 | biological_process | acetyl-CoA biosynthetic process from acetate |
| B | 0045733 | biological_process | acetate catabolic process |
| B | 1901289 | biological_process | succinyl-CoA catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 601 |
| Chain | Residue |
| A | ASN112 |
| A | ARG120 |
| A | ASN125 |
| B | GLY443 |
| B | HOH956 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 602 |
| Chain | Residue |
| A | VAL196 |
| A | ARG354 |
| A | HOH854 |
| B | ARG354 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | binding site for residue 0T1 A 603 |
| Chain | Residue |
| A | GLU294 |
| A | ASN361 |
| A | GLY362 |
| A | MET363 |
| A | ILE364 |
| A | SER374 |
| A | MET383 |
| A | ASN384 |
| A | GLY385 |
| A | ILE386 |
| A | SER389 |
| A | ALA407 |
| A | ILE412 |
| A | ACE604 |
| A | HOH707 |
| A | HOH718 |
| A | HOH743 |
| A | HOH758 |
| A | HOH772 |
| A | HOH782 |
| A | HOH817 |
| A | HOH820 |
| A | HOH839 |
| A | HOH879 |
| A | HOH915 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue ACE A 604 |
| Chain | Residue |
| A | PHE92 |
| A | LEU114 |
| A | GLU294 |
| A | GLY387 |
| A | GLY388 |
| A | 0T1603 |
| A | HOH802 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue FMT A 605 |
| Chain | Residue |
| A | ASP202 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue IMD A 606 |
| Chain | Residue |
| A | ALA419 |
| B | MET418 |
| B | ALA419 |
| B | HOH712 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue IMD A 607 |
| Chain | Residue |
| A | THR487 |
| A | LEU490 |
| A | SER491 |
| A | GLN494 |
| A | HOH829 |
| B | LEU486 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 601 |
| Chain | Residue |
| A | GLY443 |
| B | ARG120 |
| B | ASN125 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 602 |
| Chain | Residue |
| A | ARG354 |
| B | VAL196 |
| B | ARG354 |
| B | HOH852 |
| site_id | AD1 |
| Number of Residues | 27 |
| Details | binding site for residue 0T1 B 603 |
| Chain | Residue |
| B | GLY269 |
| B | VAL270 |
| B | GLY271 |
| B | ASN272 |
| B | VAL273 |
| B | GLU294 |
| B | ASN361 |
| B | MET363 |
| B | ILE364 |
| B | SER374 |
| B | ASN384 |
| B | GLY385 |
| B | ILE386 |
| B | SER389 |
| B | ALA407 |
| B | LYS408 |
| B | ILE412 |
| B | HOH726 |
| B | HOH735 |
| B | HOH769 |
| B | HOH783 |
| B | HOH786 |
| B | HOH853 |
| B | HOH867 |
| B | HOH912 |
| B | HOH917 |
| B | HOH919 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 604 |
| Chain | Residue |
| B | THR36 |
| B | SER71 |
| B | THR94 |
| B | ARG228 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue IMD B 605 |
| Chain | Residue |
| A | VAL190 |
| B | ARG258 |
| B | PRO260 |
| B | TYR397 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue IMD B 606 |
| Chain | Residue |
| B | HOH833 |
| B | HOH864 |
| A | LEU486 |
| B | THR487 |
| B | LEU490 |
| B | SER491 |
| B | GLN494 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"5-glutamyl coenzyme A thioester intermediate","evidences":[{"source":"PubMed","id":"23030530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23030530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
