5E51

Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 1 with Faropenem adduct

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008360	biological_process	regulation of cell shape
A	0009252	biological_process	peptidoglycan biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0018104	biological_process	peptidoglycan-protein cross-linking
A	0042597	cellular_component	periplasmic space
A	0071555	biological_process	cell wall organization
A	0071972	molecular_function	peptidoglycan L,D-transpeptidase activity
B	0005576	cellular_component	extracellular region
B	0008360	biological_process	regulation of cell shape
B	0009252	biological_process	peptidoglycan biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0018104	biological_process	peptidoglycan-protein cross-linking
B	0042597	cellular_component	periplasmic space
B	0071555	biological_process	cell wall organization
B	0071972	molecular_function	peptidoglycan L,D-transpeptidase activity
C	0005576	cellular_component	extracellular region
C	0008360	biological_process	regulation of cell shape
C	0009252	biological_process	peptidoglycan biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0018104	biological_process	peptidoglycan-protein cross-linking
C	0042597	cellular_component	periplasmic space
C	0071555	biological_process	cell wall organization
C	0071972	molecular_function	peptidoglycan L,D-transpeptidase activity
D	0005576	cellular_component	extracellular region
D	0008360	biological_process	regulation of cell shape
D	0009252	biological_process	peptidoglycan biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0018104	biological_process	peptidoglycan-protein cross-linking
D	0042597	cellular_component	periplasmic space
D	0071555	biological_process	cell wall organization
D	0071972	molecular_function	peptidoglycan L,D-transpeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue 5KO A 301

Chain	Residue
A	MET175
A	TYR190
A	GLY204
A	TYR206
A	HIS208
A	HIS224
A	CYS226

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000305|PubMed:23999293

Chain	Residue	Details
A	HIS208
B	HIS208
C	HIS208
D	HIS208

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000269|PubMed:23999293

Chain	Residue	Details
A	CYS226
B	CYS226
C	CYS226
D	CYS226

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	TYR190
D	TYR190
D	SER203
D	ASN228
A	SER203
A	ASN228
B	TYR190
B	SER203
B	ASN228
C	TYR190
C	SER203
C	ASN228

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Binds to carbapenem drug (covalent) => ECO:0000250

Chain	Residue	Details
A	CYS226
B	CYS226
C	CYS226
D	CYS226

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site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|Ref.2, ECO:0007744|PDB:4JMX

Chain	Residue	Details
A	HIS208
A	HIS224
B	HIS208
B	HIS224
C	HIS208
C	HIS224
D	HIS208
D	HIS224

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site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: covalent => ECO:0000269|Ref.2, ECO:0007744|PDB:4JMX

Chain	Residue	Details
A	CYS226
B	CYS226
C	CYS226
D	CYS226

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