5DX0

Crystal structure of CARM1, sinefungin, and H3 peptide (R17)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0018216	biological_process	peptidyl-arginine methylation
B	0016274	molecular_function	protein-arginine N-methyltransferase activity
B	0018216	biological_process	peptidyl-arginine methylation
C	0016274	molecular_function	protein-arginine N-methyltransferase activity
C	0018216	biological_process	peptidyl-arginine methylation
D	0016274	molecular_function	protein-arginine N-methyltransferase activity
D	0018216	biological_process	peptidyl-arginine methylation
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0030527	molecular_function	structural constituent of chromatin
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0030527	molecular_function	structural constituent of chromatin
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0030527	molecular_function	structural constituent of chromatin
I	0000786	cellular_component	nucleosome
I	0003677	molecular_function	DNA binding
I	0030527	molecular_function	structural constituent of chromatin

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue SFG A 501

Chain	Residue
A	TYR149
A	GLU214
A	ALA215
A	LYS241
A	VAL242
A	GLU243
A	GLU257
A	MET268
A	SER271
A	HOH606
A	HOH608
A	PHE150
A	HOH610
A	HOH625
F	ARG5
A	TYR153
A	GLN159
A	MET162
A	ARG168
A	CYS193
A	ILE197
A	LEU198

---

site_id	AC2
Number of Residues	2
Details	binding site for residue GOL A 502

Chain	Residue
A	ASP392
A	SER405

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 503

Chain	Residue
A	GLN148
A	LYS470
A	HOH672
B	GLN151

---

site_id	AC4
Number of Residues	22
Details	binding site for residue SFG B 501

Chain	Residue
B	TYR149
B	PHE150
B	TYR153
B	GLN159
B	MET162
B	ARG168
B	CYS193
B	ILE197
B	LEU198
B	GLU214
B	ALA215
B	LYS241
B	VAL242
B	GLU243
B	GLU257
B	MET268
B	SER271
B	HOH617
B	HOH618
B	HOH643
B	HOH647
G	ARG5

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 B 502

Chain	Residue
A	GLN151
B	GLN148
B	ARG445
B	LYS470
G	HOH103

---

site_id	AC6
Number of Residues	22
Details	binding site for residue SFG C 501

Chain	Residue
C	TYR149
C	PHE150
C	TYR153
C	GLN159
C	MET162
C	ARG168
C	CYS193
C	ILE197
C	LEU198
C	GLU214
C	ALA215
C	LYS241
C	VAL242
C	GLU243
C	GLU257
C	MET268
C	SER271
C	HOH602
C	HOH618
C	HOH623
C	HOH664
H	ARG5

---

site_id	AC7
Number of Residues	2
Details	binding site for residue GOL C 502

Chain	Residue
C	ASP392
C	TRP403

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 C 503

Chain	Residue
C	GLN148
C	ARG445
C	LYS470
D	GLN151
H	LYS2

---

site_id	AC9
Number of Residues	22
Details	binding site for residue SFG D 501

Chain	Residue
D	MET268
D	SER271
D	HOH612
D	HOH613
D	HOH640
D	HOH655
I	ARG5
D	TYR149
D	PHE150
D	TYR153
D	GLN159
D	MET162
D	ARG168
D	CYS193
D	ILE197
D	LEU198
D	GLU214
D	ALA215
D	LYS241
D	VAL242
D	GLU243
D	GLU257

---

site_id	AD1
Number of Residues	6
Details	binding site for residue SO4 D 502

Chain	Residue
C	GLN151
D	GLN148
D	ARG445
D	LYS470
D	HOH628
I	LYS2

---

Functional Information from PROSITE/UniProt

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
F	LYS2-LEU8

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
F	LYS2
B	GLU214
B	GLU243
B	SER271
C	GLN159
C	ARG168
C	GLY192
C	GLU214
C	GLU243
C	SER271
D	GLN159
G	LYS2
D	ARG168
D	GLY192
D	GLU214
D	GLU243
D	SER271
H	LYS2
I	LYS2
A	GLU243
A	SER271
B	GLN159
B	ARG168
B	GLY192

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:15345777, ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:16567635

Chain	Residue	Details
F	ARG5
G	ARG5
H	ARG5
I	ARG5

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708

Chain	Residue	Details
F	LYS6
G	LYS6
H	LYS6
I	LYS6
C	LYS227
D	LYS227

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708

Chain	Residue	Details
F	LYS11
G	LYS11
H	LYS11
I	LYS11

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Citrulline => ECO:0000269|PubMed:16567635

Chain	Residue	Details
F	ARG14
G	ARG14
H	ARG14
I	ARG14

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708, ECO:0000269|PubMed:7309716

Chain	Residue	Details
F	LYS15
G	LYS15
H	LYS15
I	LYS15

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:15851689, ECO:0000269|PubMed:16185088

Chain	Residue	Details
F	SER16
G	SER16
H	SER16
I	SER16

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806

Chain	Residue	Details
F	LYS6
G	LYS6
H	LYS6
I	LYS6

---