Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5DSV

Crystal structure of human proteasome alpha7 tetradecamer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0045202	cellular_component	synapse
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0052548	biological_process	regulation of endopeptidase activity
A	0070062	cellular_component	extracellular exosome
B	0000502	cellular_component	proteasome complex
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0045202	cellular_component	synapse
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0052548	biological_process	regulation of endopeptidase activity
B	0070062	cellular_component	extracellular exosome
C	0000502	cellular_component	proteasome complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045202	cellular_component	synapse
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0052548	biological_process	regulation of endopeptidase activity
C	0070062	cellular_component	extracellular exosome
D	0000502	cellular_component	proteasome complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0045202	cellular_component	synapse
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0052548	biological_process	regulation of endopeptidase activity
D	0070062	cellular_component	extracellular exosome
E	0000502	cellular_component	proteasome complex
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0045202	cellular_component	synapse
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0052548	biological_process	regulation of endopeptidase activity
E	0070062	cellular_component	extracellular exosome
F	0000502	cellular_component	proteasome complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0045202	cellular_component	synapse
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0052548	biological_process	regulation of endopeptidase activity
F	0070062	cellular_component	extracellular exosome
G	0000502	cellular_component	proteasome complex
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0045202	cellular_component	synapse
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0052548	biological_process	regulation of endopeptidase activity
G	0070062	cellular_component	extracellular exosome
H	0000502	cellular_component	proteasome complex
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005839	cellular_component	proteasome core complex
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0019773	cellular_component	proteasome core complex, alpha-subunit complex
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0045202	cellular_component	synapse
H	0051603	biological_process	proteolysis involved in protein catabolic process
H	0052548	biological_process	regulation of endopeptidase activity
H	0070062	cellular_component	extracellular exosome
I	0000502	cellular_component	proteasome complex
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0045202	cellular_component	synapse
I	0051603	biological_process	proteolysis involved in protein catabolic process
I	0052548	biological_process	regulation of endopeptidase activity
I	0070062	cellular_component	extracellular exosome
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0019773	cellular_component	proteasome core complex, alpha-subunit complex
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0045202	cellular_component	synapse
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0052548	biological_process	regulation of endopeptidase activity
J	0070062	cellular_component	extracellular exosome
K	0000502	cellular_component	proteasome complex
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0045202	cellular_component	synapse
K	0051603	biological_process	proteolysis involved in protein catabolic process
K	0052548	biological_process	regulation of endopeptidase activity
K	0070062	cellular_component	extracellular exosome
L	0000502	cellular_component	proteasome complex
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005839	cellular_component	proteasome core complex
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0019773	cellular_component	proteasome core complex, alpha-subunit complex
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0045202	cellular_component	synapse
L	0051603	biological_process	proteolysis involved in protein catabolic process
L	0052548	biological_process	regulation of endopeptidase activity
L	0070062	cellular_component	extracellular exosome
M	0000502	cellular_component	proteasome complex
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005839	cellular_component	proteasome core complex
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0045202	cellular_component	synapse
M	0051603	biological_process	proteolysis involved in protein catabolic process
M	0052548	biological_process	regulation of endopeptidase activity
M	0070062	cellular_component	extracellular exosome
N	0000502	cellular_component	proteasome complex
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0019773	cellular_component	proteasome core complex, alpha-subunit complex
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0045202	cellular_component	synapse
N	0051603	biological_process	proteolysis involved in protein catabolic process
N	0052548	biological_process	regulation of endopeptidase activity
N	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdlsaStFSPdGRvfQVEYAmkA

Chain	Residue	Details
A	TYR7-ALA29

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	MOD_RES: N-acetylserine => ECO:0000269\|PubMed:12376572, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
A	SER1
J	SER1
K	SER1
L	SER1
M	SER1
N	SER1
B	SER1
C	SER1
D	SER1
E	SER1
F	SER1
G	SER1
H	SER1
I	SER1

site_id	SWS_FT_FI2
Number of Residues	42
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS56
D	LYS56
D	LYS205
D	LYS229
E	LYS56
E	LYS205
E	LYS229
F	LYS56
F	LYS205
F	LYS229
G	LYS56
A	LYS205
G	LYS205
G	LYS229
H	LYS56
H	LYS205
H	LYS229
I	LYS56
I	LYS205
I	LYS229
J	LYS56
J	LYS205
A	LYS229
J	LYS229
K	LYS56
K	LYS205
K	LYS229
L	LYS56
L	LYS205
L	LYS229
M	LYS56
M	LYS205
M	LYS229
B	LYS56
N	LYS56
N	LYS205
N	LYS229
B	LYS205
B	LYS229
C	LYS56
C	LYS205
C	LYS229

site_id	SWS_FT_FI3
Number of Residues	14
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17323924, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER242
J	SER242
K	SER242
L	SER242
M	SER242
N	SER242
B	SER242
C	SER242
D	SER242
E	SER242
F	SER242
G	SER242
H	SER242
I	SER242

site_id	SWS_FT_FI4
Number of Residues	14
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:12376572, ECO:0007744\|PubMed:16964243, ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:17323924, ECO:0007744\|PubMed:17487921, ECO:0007744\|PubMed:18318008, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19367720, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER249
J	SER249
K	SER249
L	SER249
M	SER249
N	SER249
B	SER249
C	SER249
D	SER249
E	SER249
F	SER249
G	SER249
H	SER249
I	SER249

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)