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5DPR

Crystal structure of PLEKHM1 LIR-fused human LC3A_2-121

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000421cellular_componentautophagosome membrane
A0000422biological_processautophagy of mitochondrion
A0000423biological_processmitophagy
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005737cellular_componentcytoplasm
A0005770cellular_componentlate endosome
A0005776cellular_componentautophagosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0006914biological_processautophagy
A0006995biological_processcellular response to nitrogen starvation
A0007254biological_processJNK cascade
A0008017molecular_functionmicrotubule binding
A0008429molecular_functionphosphatidylethanolamine binding
A0009267biological_processcellular response to starvation
A0010040biological_processresponse to iron(II) ion
A0010288biological_processresponse to lead ion
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0031090cellular_componentorganelle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0031667biological_processresponse to nutrient levels
A0034198biological_processcellular response to amino acid starvation
A0038066biological_processp38MAPK cascade
A0043231cellular_componentintracellular membrane-bounded organelle
A0044754cellular_componentautolysosome
A0045202cellular_componentsynapse
A0060395biological_processSMAD protein signal transduction
A0070301biological_processcellular response to hydrogen peroxide
A0071280biological_processcellular response to copper ion
A0090650biological_processcellular response to oxygen-glucose deprivation
A0097352biological_processautophagosome maturation
A0098978cellular_componentglutamatergic synapse
B0000045biological_processautophagosome assembly
B0000421cellular_componentautophagosome membrane
B0000422biological_processautophagy of mitochondrion
B0000423biological_processmitophagy
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005737cellular_componentcytoplasm
B0005770cellular_componentlate endosome
B0005776cellular_componentautophagosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0006914biological_processautophagy
B0006995biological_processcellular response to nitrogen starvation
B0007254biological_processJNK cascade
B0008017molecular_functionmicrotubule binding
B0008429molecular_functionphosphatidylethanolamine binding
B0009267biological_processcellular response to starvation
B0010040biological_processresponse to iron(II) ion
B0010288biological_processresponse to lead ion
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0031090cellular_componentorganelle membrane
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0031667biological_processresponse to nutrient levels
B0034198biological_processcellular response to amino acid starvation
B0038066biological_processp38MAPK cascade
B0043231cellular_componentintracellular membrane-bounded organelle
B0044754cellular_componentautolysosome
B0045202cellular_componentsynapse
B0060395biological_processSMAD protein signal transduction
B0070301biological_processcellular response to hydrogen peroxide
B0071280biological_processcellular response to copper ion
B0090650biological_processcellular response to oxygen-glucose deprivation
B0097352biological_processautophagosome maturation
B0098978cellular_componentglutamatergic synapse
C0000045biological_processautophagosome assembly
C0000421cellular_componentautophagosome membrane
C0000422biological_processautophagy of mitochondrion
C0000423biological_processmitophagy
C0005515molecular_functionprotein binding
C0005543molecular_functionphospholipid binding
C0005737cellular_componentcytoplasm
C0005770cellular_componentlate endosome
C0005776cellular_componentautophagosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0006914biological_processautophagy
C0006995biological_processcellular response to nitrogen starvation
C0007254biological_processJNK cascade
C0008017molecular_functionmicrotubule binding
C0008429molecular_functionphosphatidylethanolamine binding
C0009267biological_processcellular response to starvation
C0010040biological_processresponse to iron(II) ion
C0010288biological_processresponse to lead ion
C0012505cellular_componentendomembrane system
C0016020cellular_componentmembrane
C0016236biological_processmacroautophagy
C0031090cellular_componentorganelle membrane
C0031410cellular_componentcytoplasmic vesicle
C0031625molecular_functionubiquitin protein ligase binding
C0031667biological_processresponse to nutrient levels
C0034198biological_processcellular response to amino acid starvation
C0038066biological_processp38MAPK cascade
C0043231cellular_componentintracellular membrane-bounded organelle
C0044754cellular_componentautolysosome
C0045202cellular_componentsynapse
C0060395biological_processSMAD protein signal transduction
C0070301biological_processcellular response to hydrogen peroxide
C0071280biological_processcellular response to copper ion
C0090650biological_processcellular response to oxygen-glucose deprivation
C0097352biological_processautophagosome maturation
C0098978cellular_componentglutamatergic synapse
D0000045biological_processautophagosome assembly
D0000421cellular_componentautophagosome membrane
D0000422biological_processautophagy of mitochondrion
D0000423biological_processmitophagy
D0005515molecular_functionprotein binding
D0005543molecular_functionphospholipid binding
D0005737cellular_componentcytoplasm
D0005770cellular_componentlate endosome
D0005776cellular_componentautophagosome
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005874cellular_componentmicrotubule
D0006914biological_processautophagy
D0006995biological_processcellular response to nitrogen starvation
D0007254biological_processJNK cascade
D0008017molecular_functionmicrotubule binding
D0008429molecular_functionphosphatidylethanolamine binding
D0009267biological_processcellular response to starvation
D0010040biological_processresponse to iron(II) ion
D0010288biological_processresponse to lead ion
D0012505cellular_componentendomembrane system
D0016020cellular_componentmembrane
D0016236biological_processmacroautophagy
D0031090cellular_componentorganelle membrane
D0031410cellular_componentcytoplasmic vesicle
D0031625molecular_functionubiquitin protein ligase binding
D0031667biological_processresponse to nutrient levels
D0034198biological_processcellular response to amino acid starvation
D0038066biological_processp38MAPK cascade
D0043231cellular_componentintracellular membrane-bounded organelle
D0044754cellular_componentautolysosome
D0045202cellular_componentsynapse
D0060395biological_processSMAD protein signal transduction
D0070301biological_processcellular response to hydrogen peroxide
D0071280biological_processcellular response to copper ion
D0090650biological_processcellular response to oxygen-glucose deprivation
D0097352biological_processautophagosome maturation
D0098978cellular_componentglutamatergic synapse
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Cleavage; by ATG4B => ECO:0000305|PubMed:15187094
ChainResidueDetails
AGLY131
BGLY131
CGLY131
DGLY131

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:20713600
ChainResidueDetails
ASER23
BSER23
CSER23
DSER23

site_idSWS_FT_FI3
Number of Residues4
DetailsLIPID: Phosphatidylserine amidated glycine; alternate => ECO:0000269|PubMed:33909989
ChainResidueDetails
AGLY131
BGLY131
CGLY131
DGLY131

229183

PDB entries from 2024-12-18

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