5DPE

Thermolysin in complex with inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004222	molecular_function	metalloendopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue 5H8 E 401

Chain	Residue
E	TYR106
E	TYR157
E	GLU166
E	LEU202
E	ARG203
E	HIS231
E	ZN402
E	DMS409
E	DMS409
E	GOL411
E	HOH572
E	ASN111
E	HOH629
E	HOH679
E	ASN112
E	ALA113
E	PHE114
E	TRP115
E	HIS142
E	GLU143
E	HIS146

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN E 402

Chain	Residue
E	HIS142
E	HIS146
E	GLU166
E	5H8401

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA E 403

Chain	Residue
E	ASP138
E	GLU177
E	ASP185
E	GLU187
E	GLU190
E	HOH602

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA E 404

Chain	Residue
E	ASP57
E	ASP59
E	GLN61
E	HOH556
E	HOH605
E	HOH780

---

site_id	AC5
Number of Residues	6
Details	binding site for residue CA E 405

Chain	Residue
E	GLU177
E	ASN183
E	ASP185
E	GLU190
E	HOH560
E	HOH631

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA E 406

Chain	Residue
E	TYR193
E	THR194
E	ILE197
E	ASP200
E	HOH615
E	HOH751

---

site_id	AC7
Number of Residues	5
Details	binding site for residue DMS E 407

Chain	Residue
E	ILE1
E	THR2
E	GLY3
E	GLN31
E	ASN33

---

site_id	AC8
Number of Residues	5
Details	binding site for residue DMS E 408

Chain	Residue
E	GLY95
E	PRO184
E	TRP186
E	HOH666
E	HOH688

---

site_id	AC9
Number of Residues	5
Details	binding site for residue DMS E 409

Chain	Residue
E	TYR110
E	ASN112
E	PHE114
E	5H8401
E	5H8401

---

site_id	AD1
Number of Residues	6
Details	binding site for residue DMS E 410

Chain	Residue
E	TYR66
E	HIS216
E	SER218
E	TYR251
E	HOH867
E	HOH873

---

site_id	AD2
Number of Residues	8
Details	binding site for residue GOL E 411

Chain	Residue
E	PHE114
E	TRP115
E	HIS146
E	TYR157
E	5H8401
E	HOH513
E	HOH536
E	HOH703

---

site_id	AD3
Number of Residues	7
Details	binding site for residue GOL E 412

Chain	Residue
E	GLY109
E	TYR110
E	ASN111
E	ASN112
E	GLN158
E	HOH616
E	HOH756

---

site_id	AD4
Number of Residues	12
Details	binding site for residue GOL E 413

Chain	Residue
E	GLY247
E	GLY248
E	THR249
E	VAL255
E	GLN273
E	TYR274
E	LEU275
E	HOH553
E	HOH558
E	HOH654
E	HOH667
E	HOH766

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV

Chain	Residue	Details
E	VAL139-VAL148

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 176

Chain

Residue

Details

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