5DP4

Crystal Structure of EV71 3C Proteinase in complex with compound 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 5E8 A 201

Chain	Residue
A	ARG39
A	HIS161
A	ILE162
A	GLY163
A	GLY164
A	HIS40
A	LEU127
A	SER128
A	THR142
A	LYS143
A	ALA144
A	GLY145
A	CYS147

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site_id	AC2
Number of Residues	20
Details	binding site for Di-peptide 5E8 B 201 and CYS B 147

Chain	Residue
B	PHE25
B	THR26
B	ARG39
B	HIS40
B	GLU71
B	LEU127
B	SER128
B	THR142
B	LYS143
B	ALA144
B	GLY145
B	GLN146
B	GLY148
B	GLY149
B	HIS161
B	ILE162
B	GLY163
B	GLY164
B	HOH349
B	HOH387

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site_id	AC3
Number of Residues	20
Details	binding site for Di-peptide 5E8 C 201 and CYS C 147

Chain	Residue
C	PHE25
C	THR26
C	ARG39
C	HIS40
C	GLU71
C	LEU127
C	SER128
C	THR142
C	LYS143
C	ALA144
C	GLY145
C	GLN146
C	GLY148
C	GLY149
C	HIS161
C	ILE162
C	GLY163
C	GLY164
C	HOH335
C	HOH354

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site_id	AC4
Number of Residues	19
Details	binding site for Di-peptide 5E8 D 201 and CYS D 147

Chain	Residue
D	PHE25
D	THR26
D	ARG39
D	HIS40
D	LEU127
D	SER128
D	THR142
D	LYS143
D	ALA144
D	GLY145
D	GLN146
D	GLY148
D	GLY149
D	HIS161
D	ILE162
D	GLY163
D	GLY164
D	HOH334
D	HOH355

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