5DKA
A C2HC zinc finger is essential for the activity of the RING ubiquitin ligase RNF125
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000209 | biological_process | protein polyubiquitination |
| A | 0002039 | molecular_function | p53 binding |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0005515 | molecular_function | protein binding |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016740 | molecular_function | transferase activity |
| A | 0031624 | molecular_function | ubiquitin conjugating enzyme binding |
| A | 0032480 | biological_process | negative regulation of type I interferon production |
| A | 0034098 | cellular_component | VCP-NPL4-UFD1 AAA ATPase complex |
| A | 0039536 | biological_process | negative regulation of RIG-I signaling pathway |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0061630 | molecular_function | ubiquitin protein ligase activity |
| A | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000209 | biological_process | protein polyubiquitination |
| B | 0002039 | molecular_function | p53 binding |
| B | 0002250 | biological_process | adaptive immune response |
| B | 0005515 | molecular_function | protein binding |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016020 | cellular_component | membrane |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0016740 | molecular_function | transferase activity |
| B | 0031624 | molecular_function | ubiquitin conjugating enzyme binding |
| B | 0032480 | biological_process | negative regulation of type I interferon production |
| B | 0034098 | cellular_component | VCP-NPL4-UFD1 AAA ATPase complex |
| B | 0039536 | biological_process | negative regulation of RIG-I signaling pathway |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0061630 | molecular_function | ubiquitin protein ligase activity |
| B | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | CYS37 |
| A | CYS40 |
| A | CYS57 |
| A | CYS60 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 302 |
| Chain | Residue |
| A | CYS100 |
| A | CYS103 |
| A | HIS115 |
| A | CYS119 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 303 |
| Chain | Residue |
| A | HIS54 |
| A | CYS72 |
| A | CYS75 |
| A | CYS52 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 304 |
| Chain | Residue |
| A | THR105 |
| A | LEU106 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | CYS37 |
| B | CYS40 |
| B | CYS57 |
| B | CYS60 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 302 |
| Chain | Residue |
| B | CYS100 |
| B | CYS103 |
| B | HIS115 |
| B | CYS119 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 303 |
| Chain | Residue |
| B | CYS52 |
| B | HIS54 |
| B | CYS72 |
| B | CYS75 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 304 |
| Chain | Residue |
| B | ASP36 |
| B | VAL43 |
| B | LYS98 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 305 |
| Chain | Residue |
| B | TRP70 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 306 |
| Chain | Residue |
| A | HOH408 |
| B | ALA77 |
| B | TYR78 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 307 |
| Chain | Residue |
| B | LEU106 |
Functional Information from PROSITE/UniProt
| site_id | PS00518 |
| Number of Residues | 10 |
| Details | ZF_RING_1 Zinc finger RING-type signature. CgHvFCrsCI |
| Chain | Residue | Details |
| A | CYS52-ILE61 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 |
| Chain | Residue | Details |
| A | CYS37-ARG76 | |
| B | CYS37-ARG76 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | ZN_FING: C2HC RNF-type => ECO:0000255|PROSITE-ProRule:PRU01144, ECO:0000303|PubMed:17990982 |
| Chain | Residue | Details |
| A | CYS100-CYS119 | |
| B | CYS100-CYS119 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27411375, ECO:0007744|PDB:5DKA |
| Chain | Residue | Details |
| A | CYS37 | |
| B | CYS40 | |
| B | CYS52 | |
| B | HIS54 | |
| B | CYS57 | |
| B | CYS60 | |
| B | CYS72 | |
| B | CYS75 | |
| A | CYS40 | |
| A | CYS52 | |
| A | HIS54 | |
| A | CYS57 | |
| A | CYS60 | |
| A | CYS72 | |
| A | CYS75 | |
| B | CYS37 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01144, ECO:0000269|PubMed:27411375, ECO:0007744|PDB:5DKA |
| Chain | Residue | Details |
| A | CYS100 | |
| A | CYS103 | |
| A | HIS115 | |
| A | CYS119 | |
| B | CYS100 | |
| B | CYS103 | |
| B | HIS115 | |
| B | CYS119 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:17990982 |
| Chain | Residue | Details |
| A | GLY2 | |
| B | GLY2 |
