5DKA

A C2HC zinc finger is essential for the activity of the RING ubiquitin ligase RNF125

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000209	biological_process	protein polyubiquitination
A	0002039	molecular_function	p53 binding
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0008270	molecular_function	zinc ion binding
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0031624	molecular_function	ubiquitin conjugating enzyme binding
A	0032480	biological_process	negative regulation of type I interferon production
A	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
A	0039536	biological_process	negative regulation of RIG-I signaling pathway
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046872	molecular_function	metal ion binding
A	0061630	molecular_function	ubiquitin protein ligase activity
B	0000139	cellular_component	Golgi membrane
B	0000209	biological_process	protein polyubiquitination
B	0002039	molecular_function	p53 binding
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0008270	molecular_function	zinc ion binding
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0031624	molecular_function	ubiquitin conjugating enzyme binding
B	0032480	biological_process	negative regulation of type I interferon production
B	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
B	0039536	biological_process	negative regulation of RIG-I signaling pathway
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046872	molecular_function	metal ion binding
B	0061630	molecular_function	ubiquitin protein ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	CYS37
A	CYS40
A	CYS57
A	CYS60

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 302

Chain	Residue
A	CYS100
A	CYS103
A	HIS115
A	CYS119

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 303

Chain	Residue
A	HIS54
A	CYS72
A	CYS75
A	CYS52

---

site_id	AC4
Number of Residues	2
Details	binding site for residue CL A 304

Chain	Residue
A	THR105
A	LEU106

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	CYS37
B	CYS40
B	CYS57
B	CYS60

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 302

Chain	Residue
B	CYS100
B	CYS103
B	HIS115
B	CYS119

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 303

Chain	Residue
B	CYS52
B	HIS54
B	CYS72
B	CYS75

---

site_id	AC8
Number of Residues	3
Details	binding site for residue MG B 304

Chain	Residue
B	ASP36
B	VAL43
B	LYS98

---

site_id	AC9
Number of Residues	1
Details	binding site for residue CL B 305

Chain	Residue
B	TRP70

---

site_id	AD1
Number of Residues	3
Details	binding site for residue CL B 306

Chain	Residue
A	HOH408
B	ALA77
B	TYR78

---

site_id	AD2
Number of Residues	1
Details	binding site for residue CL B 307

Chain	Residue
B	LEU106

---

Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHvFCrsCI

Chain	Residue	Details
A	CYS52-ILE61

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	38
Details	Zinc finger: {"description":"C2HC RNF-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01144","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17990982","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"Interaction with the C2HC RNF-type zinc finger","evidences":[{"source":"PubMed","id":"27411375","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Region: {"description":"Interaction with the RING-type zinc finger","evidences":[{"source":"PubMed","id":"27411375","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Region: {"description":"Linker region","evidences":[{"source":"PubMed","id":"27411375","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27411375","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DKA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01144","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27411375","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DKA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---