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5DIS

Crystal structure of a CRM1-RanGTP-SPN1 export complex bound to a 113 amino acid FG-repeat containing fragment of Nup214

Functional Information from GO Data
ChainGOidnamespacecontents
A0000054biological_processribosomal subunit export from nucleus
A0000055biological_processribosomal large subunit export from nucleus
A0000056biological_processribosomal small subunit export from nucleus
A0000776cellular_componentkinetochore
A0003723molecular_functionRNA binding
A0005049molecular_functionnuclear export signal receptor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005642cellular_componentannulate lamellae
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006406biological_processmRNA export from nucleus
A0006611biological_processprotein export from nucleus
A0006886biological_processintracellular protein transport
A0006913biological_processnucleocytoplasmic transport
A0010824biological_processregulation of centrosome duplication
A0015030cellular_componentCajal body
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0031267molecular_functionsmall GTPase binding
A0031965cellular_componentnuclear membrane
A0032434biological_processregulation of proteasomal ubiquitin-dependent protein catabolic process
A0032991cellular_componentprotein-containing complex
A0034504biological_processprotein localization to nucleus
A0042176biological_processregulation of protein catabolic process
A0042254biological_processribosome biogenesis
A0043231cellular_componentintracellular membrane-bounded organelle
A0046825biological_processregulation of protein export from nucleus
A0051028biological_processmRNA transport
A1990904cellular_componentribonucleoprotein complex
B0003924molecular_functionGTPase activity
B0005525molecular_functionGTP binding
B0006913biological_processnucleocytoplasmic transport
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0006606biological_processprotein import into nucleus
C0061015biological_processsnRNA import into nucleus
C0061608molecular_functionnuclear import signal receptor activity
D0005515molecular_functionprotein binding
D0006974biological_processDNA damage response
D0008643biological_processcarbohydrate transport
D0015144molecular_functioncarbohydrate transmembrane transporter activity
D0015768biological_processmaltose transport
D0016020cellular_componentmembrane
D0030288cellular_componentouter membrane-bounded periplasmic space
D0034219biological_processcarbohydrate transmembrane transport
D0034289biological_processdetection of maltose stimulus
D0042597cellular_componentperiplasmic space
D0042956biological_processmaltodextrin transmembrane transport
D0043190cellular_componentATP-binding cassette (ABC) transporter complex
D0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
D0055085biological_processtransmembrane transport
D0060326biological_processcell chemotaxis
D0071702biological_processorganic substance transport
D1901982molecular_functionmaltose binding
D1990060cellular_componentmaltose transport complex
Functional Information from PROSITE/UniProt
site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
DPRO107-ASN124

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Breakpoint for translocation to form the NUP214-ABL1 fusion protein => ECO:0000269|PubMed:15361874
ChainResidueDetails
DSER1916
CLYS144
CTRP276

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Breakpoint for translocation to form the NUP214-SQSTM1 fusion protein => ECO:0000269|PubMed:20851865
ChainResidueDetails
DTHR1967
ALYS693

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
DSER1963

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
DSER1985

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10078529, ECO:0000269|PubMed:10353245, ECO:0000269|PubMed:10367892, ECO:0000269|PubMed:11832950, ECO:0000269|PubMed:18611384, ECO:0000269|PubMed:19389996, ECO:0000269|PubMed:19505478, ECO:0000269|PubMed:24449914, ECO:0000269|PubMed:24915079, ECO:0000269|PubMed:26272610, ECO:0000269|PubMed:26349033, ECO:0000269|PubMed:28282025, ECO:0000269|PubMed:7885480, ECO:0007744|PDB:1K5G, ECO:0007744|PDB:3CH5, ECO:0007744|PDB:3GJ0, ECO:0007744|PDB:3GJ3, ECO:0007744|PDB:3GJ4, ECO:0007744|PDB:3GJ5, ECO:0007744|PDB:3GJ6, ECO:0007744|PDB:3GJ7, ECO:0007744|PDB:3GJ8, ECO:0007744|PDB:3GJX, ECO:0007744|PDB:3NBY, ECO:0007744|PDB:3NBZ, ECO:0007744|PDB:3NC0, ECO:0007744|PDB:3NC1, ECO:0007744|PDB:3ZJY, ECO:0007744|PDB:4C0Q, ECO:0007744|PDB:4OL0, ECO:0007744|PDB:5CIQ, ECO:0007744|PDB:5CIT, ECO:0007744|PDB:5CIW, ECO:0007744|PDB:5CJ2, ECO:0007744|PDB:5CLL, ECO:0007744|PDB:5CLQ, ECO:0007744|PDB:5DH9, ECO:0007744|PDB:5DHA, ECO:0007744|PDB:5DHF, ECO:0007744|PDB:5DI9, ECO:0007744|PDB:5DIF, ECO:0007744|PDB:5DIS, ECO:0007744|PDB:5DLQ, ECO:0007744|PDB:5JLJ, ECO:0007744|PDB:5UWH, ECO:0007744|PDB:5UWI, ECO:0007744|PDB:5UWJ, ECO:0007744|PDB:5UWO, ECO:0007744|PDB:5UWP, ECO:0007744|PDB:5UWQ, ECO:0007744|PDB:5UWR, ECO:0007744|PDB:5UWS, ECO:0007744|PDB:5UWT, ECO:0007744|PDB:5UWU, ECO:0007744|PDB:5UWW
ChainResidueDetails
BSER150

site_idSWS_FT_FI6
Number of Residues1
DetailsSITE: Essential for GTP hydrolysis => ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:26272610, ECO:0000269|PubMed:8636225
ChainResidueDetails
BLEU69

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR24

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:31075303
ChainResidueDetails
BLYS37

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS60
BLYS99

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS71

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:29040603
ChainResidueDetails
BLYS134

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62827
ChainResidueDetails
BLYS159

site_idSWS_FT_FI13
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
BLYS71

site_idSWS_FT_FI14
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS152

218853

PDB entries from 2024-04-24

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