5DGH
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMP-PNP and 5-(PCP)-IP5
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000829 | molecular_function | inositol heptakisphosphate kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 26 |
Details | binding site for residue ANP A 401 |
Chain | Residue |
A | ARG134 |
A | PHE239 |
A | MET240 |
A | ASP246 |
A | SER264 |
A | ASP309 |
A | LEU311 |
A | CYS320 |
A | ASP321 |
A | ASN323 |
A | MG403 |
A | PRO149 |
A | MG404 |
A | HOH501 |
A | HOH533 |
A | HOH563 |
A | HOH574 |
A | HOH637 |
A | HOH685 |
A | VAL185 |
A | LYS187 |
A | HIS194 |
A | LEU211 |
A | ARG213 |
A | GLU237 |
A | GLU238 |
site_id | AC2 |
Number of Residues | 25 |
Details | binding site for residue 5A3 A 402 |
Chain | Residue |
A | LYS53 |
A | LYS54 |
A | ARG213 |
A | LYS214 |
A | LYS248 |
A | TYR250 |
A | ARG262 |
A | ARG273 |
A | SER326 |
A | LYS329 |
A | MG407 |
A | EDO410 |
A | HOH501 |
A | HOH506 |
A | HOH519 |
A | HOH557 |
A | HOH559 |
A | HOH568 |
A | HOH579 |
A | HOH580 |
A | HOH583 |
A | HOH585 |
A | HOH605 |
A | HOH608 |
A | HOH651 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue MG A 403 |
Chain | Residue |
A | ASP321 |
A | ASN323 |
A | ANP401 |
A | HOH563 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue MG A 404 |
Chain | Residue |
A | ASP309 |
A | ASP321 |
A | ANP401 |
A | HOH574 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue MG A 405 |
Chain | Residue |
A | SER68 |
A | PHE70 |
A | ILE73 |
A | HOH540 |
A | HOH654 |
A | HOH701 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue MG A 406 |
Chain | Residue |
A | HOH506 |
A | HOH520 |
A | HOH571 |
A | HOH587 |
A | HOH697 |
A | HOH731 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue MG A 407 |
Chain | Residue |
A | 5A3402 |
A | HOH559 |
A | HOH568 |
A | HOH651 |
A | HOH728 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue EDO A 408 |
Chain | Residue |
A | ASN90 |
A | TRP91 |
A | PRO92 |
A | ILE285 |
A | HOH617 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue ACT A 409 |
Chain | Residue |
A | SER217 |
A | ARG218 |
A | LYS270 |
A | LEU292 |
A | HOH588 |
site_id | AD1 |
Number of Residues | 9 |
Details | binding site for residue EDO A 410 |
Chain | Residue |
A | LYS248 |
A | VAL249 |
A | TYR250 |
A | GLY307 |
A | PHE308 |
A | ASP309 |
A | ASN323 |
A | SER326 |
A | 5A3402 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue EDO A 411 |
Chain | Residue |
A | HOH525 |
A | ARG312 |
A | GLY315 |
A | GLN316 |
A | SER317 |
site_id | AD3 |
Number of Residues | 7 |
Details | binding site for residue EDO A 412 |
Chain | Residue |
A | PRO87 |
A | GLU89 |
A | ASN90 |
A | TYR256 |
A | HIS258 |
A | TYR334 |
A | HOH670 |
site_id | AD4 |
Number of Residues | 1 |
Details | binding site for residue ACT A 413 |
Chain | Residue |
A | HOH620 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue EDO A 414 |
Chain | Residue |
A | PHE105 |
A | PRO106 |
A | LEU107 |
A | ASP108 |
A | HOH517 |
A | HOH621 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue EDO A 415 |
Chain | Residue |
A | VAL121 |
A | ASP124 |
A | LEU125 |
A | ASN126 |
A | HOH537 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | LYS53 | |
A | LYS248 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T7A, ECO:0007744|PDB:3T99, ECO:0007744|PDB:3T9A, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | ARG134 | |
A | LYS187 | |
A | HIS194 | |
A | GLU237 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9A, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D |
Chain | Residue | Details |
A | ARG213 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T9A, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D |
Chain | Residue | Details |
A | ASP246 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | ARG262 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T7A |
Chain | Residue | Details |
A | SER264 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T7A, ECO:0007744|PDB:3T99, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | ASP309 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54 |
Chain | Residue | Details |
A | ASP321 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E |
Chain | Residue | Details |
A | SER326 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER223 |