5DED
Crystal structure of the small alarmone synthethase 1 from Bacillus subtilis bound to its product pppGpp
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0008728 | molecular_function | GTP diphosphokinase activity |
| A | 0015969 | biological_process | guanosine tetraphosphate metabolic process |
| A | 0015970 | biological_process | guanosine tetraphosphate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0008728 | molecular_function | GTP diphosphokinase activity |
| B | 0015969 | biological_process | guanosine tetraphosphate metabolic process |
| B | 0015970 | biological_process | guanosine tetraphosphate biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0008728 | molecular_function | GTP diphosphokinase activity |
| C | 0015969 | biological_process | guanosine tetraphosphate metabolic process |
| C | 0015970 | biological_process | guanosine tetraphosphate biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005525 | molecular_function | GTP binding |
| D | 0008728 | molecular_function | GTP diphosphokinase activity |
| D | 0015969 | biological_process | guanosine tetraphosphate metabolic process |
| D | 0015970 | biological_process | guanosine tetraphosphate biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005525 | molecular_function | GTP binding |
| E | 0008728 | molecular_function | GTP diphosphokinase activity |
| E | 0015969 | biological_process | guanosine tetraphosphate metabolic process |
| E | 0015970 | biological_process | guanosine tetraphosphate biosynthetic process |
| E | 0016301 | molecular_function | kinase activity |
| E | 0016740 | molecular_function | transferase activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005525 | molecular_function | GTP binding |
| F | 0008728 | molecular_function | GTP diphosphokinase activity |
| F | 0015969 | biological_process | guanosine tetraphosphate metabolic process |
| F | 0015970 | biological_process | guanosine tetraphosphate biosynthetic process |
| F | 0016301 | molecular_function | kinase activity |
| F | 0016740 | molecular_function | transferase activity |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005525 | molecular_function | GTP binding |
| G | 0008728 | molecular_function | GTP diphosphokinase activity |
| G | 0015969 | biological_process | guanosine tetraphosphate metabolic process |
| G | 0015970 | biological_process | guanosine tetraphosphate biosynthetic process |
| G | 0016301 | molecular_function | kinase activity |
| G | 0016740 | molecular_function | transferase activity |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005525 | molecular_function | GTP binding |
| H | 0008728 | molecular_function | GTP diphosphokinase activity |
| H | 0015969 | biological_process | guanosine tetraphosphate metabolic process |
| H | 0015970 | biological_process | guanosine tetraphosphate biosynthetic process |
| H | 0016301 | molecular_function | kinase activity |
| H | 0016740 | molecular_function | transferase activity |
| H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue 0O2 D 301 |
| Chain | Residue |
| D | ARG46 |
| D | TYR116 |
| D | HIS120 |
| D | GLU139 |
| D | GLN141 |
| D | ALA151 |
| D | GLU154 |
| D | HIS155 |
| D | LYS48 |
| D | LYS56 |
| D | ARG59 |
| D | ASP72 |
| D | ARG105 |
| D | TYR107 |
| D | LYS112 |
| D | SER114 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue 0O2 D 302 |
| Chain | Residue |
| B | LYS21 |
| B | LYS25 |
| B | ARG28 |
| B | PHE42 |
| B | THR44 |
| B | ASN148 |
| B | MG302 |
| D | LYS21 |
| D | LYS25 |
| D | GLU41 |
| D | PHE42 |
| D | THR44 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue 0O2 A 301 |
| Chain | Residue |
| A | ARG46 |
| A | LYS48 |
| A | LYS56 |
| A | ARG59 |
| A | LYS60 |
| A | ASP72 |
| A | ARG105 |
| A | TYR107 |
| A | LYS112 |
| A | SER114 |
| A | TYR116 |
| A | HIS120 |
| A | GLU139 |
| A | GLN141 |
| A | ALA151 |
| A | GLU154 |
| A | HIS155 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue 0O2 A 302 |
| Chain | Residue |
| A | LYS21 |
| A | LYS25 |
| A | GLU41 |
| A | PHE42 |
| A | VAL43 |
| A | MG303 |
| C | LYS21 |
| C | LYS25 |
| C | ARG28 |
| C | PHE42 |
| C | THR44 |
| C | ASN148 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue MG A 303 |
| Chain | Residue |
| A | 0O2302 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue 0O2 B 301 |
| Chain | Residue |
| B | ARG46 |
| B | LYS48 |
| B | LYS56 |
| B | ARG59 |
| B | LYS60 |
| B | ASP72 |
| B | ARG105 |
| B | TYR107 |
| B | LYS112 |
| B | SER114 |
| B | TYR116 |
| B | HIS120 |
| B | GLU139 |
| B | GLN141 |
| B | ALA151 |
| B | GLU154 |
| B | HIS155 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue MG B 302 |
| Chain | Residue |
| D | 0O2302 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | binding site for residue 0O2 C 301 |
| Chain | Residue |
| C | ARG46 |
| C | LYS48 |
| C | LYS56 |
| C | ARG59 |
| C | LYS60 |
| C | ASP72 |
| C | ARG105 |
| C | TYR107 |
| C | LYS112 |
| C | SER114 |
| C | TYR116 |
| C | HIS120 |
| C | GLU139 |
| C | GLN141 |
| C | ALA151 |
| C | GLU154 |
| C | HIS155 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | binding site for residue 0O2 E 301 |
| Chain | Residue |
| E | SER114 |
| E | TYR116 |
| E | HIS120 |
| E | GLU139 |
| E | GLN141 |
| E | ALA151 |
| E | GLU154 |
| E | HIS155 |
| E | ARG46 |
| E | LYS48 |
| E | LYS60 |
| E | ARG105 |
| E | TYR107 |
| E | LYS112 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue MG E 302 |
| Chain | Residue |
| H | 0O2302 |
| site_id | AD2 |
| Number of Residues | 16 |
| Details | binding site for residue 0O2 F 301 |
| Chain | Residue |
| F | LYS48 |
| F | LYS56 |
| F | ARG59 |
| F | ASP72 |
| F | ARG77 |
| F | ARG105 |
| F | TYR107 |
| F | LYS112 |
| F | SER114 |
| F | TYR116 |
| F | HIS120 |
| F | GLU139 |
| F | GLN141 |
| F | ALA151 |
| F | GLU154 |
| F | HIS155 |
| site_id | AD3 |
| Number of Residues | 16 |
| Details | binding site for residue 0O2 G 301 |
| Chain | Residue |
| G | ARG46 |
| G | LYS48 |
| G | LYS56 |
| G | ARG59 |
| G | ASP72 |
| G | ARG105 |
| G | TYR107 |
| G | LYS112 |
| G | SER114 |
| G | TYR116 |
| G | HIS120 |
| G | GLU139 |
| G | GLN141 |
| G | ALA151 |
| G | GLU154 |
| G | HIS155 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for residue 0O2 G 302 |
| Chain | Residue |
| F | LYS21 |
| F | LYS25 |
| F | ARG28 |
| F | PHE42 |
| F | THR44 |
| G | LYS25 |
| G | ARG28 |
| G | GLU41 |
| G | PHE42 |
| G | THR44 |
| G | MG303 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue MG G 303 |
| Chain | Residue |
| G | 0O2302 |
| site_id | AD6 |
| Number of Residues | 17 |
| Details | binding site for residue 0O2 H 301 |
| Chain | Residue |
| H | ARG46 |
| H | LYS48 |
| H | LYS56 |
| H | ARG59 |
| H | LYS60 |
| H | ASP72 |
| H | ARG105 |
| H | TYR107 |
| H | LYS112 |
| H | SER114 |
| H | TYR116 |
| H | HIS120 |
| H | GLU139 |
| H | GLN141 |
| H | ALA151 |
| H | GLU154 |
| H | HIS155 |
| site_id | AD7 |
| Number of Residues | 14 |
| Details | binding site for residue 0O2 H 302 |
| Chain | Residue |
| E | LYS21 |
| E | LYS25 |
| E | ARG28 |
| E | PHE42 |
| E | THR44 |
| E | ASN148 |
| E | MG302 |
| H | LYS21 |
| H | LYS25 |
| H | ARG28 |
| H | GLU41 |
| H | PHE42 |
| H | VAL43 |
| H | THR44 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"26460002","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 160 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26460002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DED","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26460002","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5F2V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26460002","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
