5DDY

Binary complex of human Polymerase lambda with dCTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity
C	0003677	molecular_function	DNA binding
C	0003887	molecular_function	DNA-directed DNA polymerase activity
C	0006281	biological_process	DNA repair
C	0016779	molecular_function	nucleotidyltransferase activity
C	0034061	molecular_function	DNA polymerase activity
E	0003677	molecular_function	DNA binding
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	0006281	biological_process	DNA repair
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034061	molecular_function	DNA polymerase activity
G	0003677	molecular_function	DNA binding
G	0003887	molecular_function	DNA-directed DNA polymerase activity
G	0006281	biological_process	DNA repair
G	0016779	molecular_function	nucleotidyltransferase activity
G	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 601

Chain	Residue
A	GLY416
A	SER417
A	ASP427
A	ASP429
A	DCP603

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MN A 602

Chain	Residue
A	ASP427
A	ASP429
A	ASP490
A	DCP603

---

site_id	AC3
Number of Residues	14
Details	binding site for residue DCP A 603

Chain	Residue
A	ARG386
A	GLY416
A	SER417
A	ARG420
A	GLY426
A	ASP427
A	ASP429
A	TYR505
A	PHE506
A	THR507
A	GLY508
A	ASN513
A	MG601
A	MN602

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MN A 604

Chain	Residue
A	SER339
A	ILE341
A	ALA344

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MG C 601

Chain	Residue
C	GLY416
C	SER417
C	ASP427
C	ASP429
C	DCP603

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MN C 602

Chain	Residue
C	ASP427
C	ASP429
C	ASP490
C	DCP603

---

site_id	AC7
Number of Residues	13
Details	binding site for residue DCP C 603

Chain	Residue
C	ARG386
C	GLY416
C	SER417
C	ARG420
C	GLY426
C	ASP427
C	ASP429
C	TYR505
C	PHE506
C	GLY508
C	ASN513
C	MG601
C	MN602

---

site_id	AC8
Number of Residues	2
Details	binding site for residue MN C 604

Chain	Residue
C	SER339
C	HOH701

---

site_id	AC9
Number of Residues	5
Details	binding site for residue MG E 601

Chain	Residue
E	GLY416
E	SER417
E	ASP427
E	ASP429
E	DCP603

---

site_id	AD1
Number of Residues	4
Details	binding site for residue MN E 602

Chain	Residue
E	ASP427
E	ASP429
E	ASP490
E	DCP603

---

site_id	AD2
Number of Residues	11
Details	binding site for residue DCP E 603

Chain	Residue
E	ARG386
E	SER417
E	ARG420
E	GLY426
E	ASP427
E	ASP429
E	TYR505
E	PHE506
E	GLY508
E	MG601
E	MN602

---

site_id	AD3
Number of Residues	2
Details	binding site for residue MN E 604

Chain	Residue
E	SER339
E	ILE341

---

site_id	AD4
Number of Residues	5
Details	binding site for residue MG G 601

Chain	Residue
G	GLY416
G	SER417
G	ASP427
G	ASP429
G	DCP603

---

site_id	AD5
Number of Residues	4
Details	binding site for residue MN G 602

Chain	Residue
G	ASP427
G	ASP429
G	ASP490
G	DCP603

---

site_id	AD6
Number of Residues	13
Details	binding site for residue DCP G 603

Chain	Residue
G	ARG386
G	SER417
G	ARG420
G	GLY426
G	ASP427
G	ASP429
G	TYR505
G	PHE506
G	THR507
G	GLY508
G	ASN513
G	MG601
G	MN602

---

site_id	AD7
Number of Residues	3
Details	binding site for residue MN G 604

Chain	Residue
G	SER339
G	ILE341
G	ALA344

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	196
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"14992725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Region: {"description":"Involved in primer binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"11457865","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---