5DCY
Iridoid synthase G150A mutant from Catharanthus roseus - binary complex with NADP+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006720 | biological_process | isoprenoid metabolic process |
| A | 0016099 | biological_process | monoterpenoid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016628 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006720 | biological_process | isoprenoid metabolic process |
| B | 0016099 | biological_process | monoterpenoid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016628 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | binding site for residue NAP A 900 |
| Chain | Residue |
| A | GLY36 |
| A | VAL85 |
| A | SER86 |
| A | SER108 |
| A | TRP109 |
| A | MET121 |
| A | GLN142 |
| A | THR143 |
| A | TYR178 |
| A | PRO201 |
| A | ALA202 |
| A | THR38 |
| A | VAL204 |
| A | SER211 |
| A | MET212 |
| A | MET213 |
| A | PGE901 |
| A | HOH1020 |
| A | HOH1036 |
| A | HOH1065 |
| A | HOH1073 |
| A | HOH1083 |
| A | GLY39 |
| A | HOH1143 |
| A | HOH1241 |
| A | ILE40 |
| A | ALA65 |
| A | ARG66 |
| A | ARG67 |
| A | CYS83 |
| A | ASP84 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue PGE A 901 |
| Chain | Residue |
| A | GLU113 |
| A | LYS146 |
| A | ILE151 |
| A | ASN176 |
| A | PHE177 |
| A | TYR178 |
| A | MET213 |
| A | ILE345 |
| A | NAP900 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 902 |
| Chain | Residue |
| A | HIS147 |
| A | ARG171 |
| A | GLU182 |
| A | ARG200 |
| A | HOH1003 |
| A | HOH1051 |
| A | HOH1101 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 903 |
| Chain | Residue |
| A | ILE225 |
| A | GLU229 |
| A | MET313 |
| A | LYS316 |
| A | HOH1121 |
| A | HOH1151 |
| site_id | AC5 |
| Number of Residues | 32 |
| Details | binding site for residue NAP B 900 |
| Chain | Residue |
| B | GLY36 |
| B | THR38 |
| B | GLY39 |
| B | ILE40 |
| B | ALA65 |
| B | ARG66 |
| B | ARG67 |
| B | CYS83 |
| B | ASP84 |
| B | VAL85 |
| B | SER108 |
| B | TRP109 |
| B | MET121 |
| B | GLN142 |
| B | THR143 |
| B | TYR178 |
| B | PRO201 |
| B | ALA202 |
| B | VAL204 |
| B | SER211 |
| B | MET212 |
| B | MET213 |
| B | PGE901 |
| B | HOH1001 |
| B | HOH1008 |
| B | HOH1037 |
| B | HOH1040 |
| B | HOH1043 |
| B | HOH1049 |
| B | HOH1085 |
| B | HOH1173 |
| B | HOH1220 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue PGE B 901 |
| Chain | Residue |
| B | GLU113 |
| B | LYS146 |
| B | ASN176 |
| B | PHE177 |
| B | TYR178 |
| B | MET213 |
| B | NAP900 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 902 |
| Chain | Residue |
| B | HOH1252 |
| B | ALA310 |
| B | ALA338 |
| B | ALA339 |
| B | PHE340 |
| B | TRP341 |
| B | HOH1077 |
| B | HOH1152 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 903 |
| Chain | Residue |
| B | ILE225 |
| B | CYS226 |
| B | GLU229 |
| B | MET313 |
| B | HOH1036 |
| B | HOH1059 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 904 |
| Chain | Residue |
| B | HIS147 |
| B | ARG171 |
| B | GLU182 |
| B | ARG200 |
| B | HOH1004 |
| B | HOH1050 |
| B | HOH1069 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 905 |
| Chain | Residue |
| B | ASP250 |
| B | ASP252 |
| B | ARG368 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"26768532","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26551396","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26768532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26868105","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5COB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DF1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26768532","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DBI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26768532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26868105","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5COB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DBI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26768532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26868105","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5COB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
