5DBM

Crystal structure of the CBP bromodomain in complex with CPI703

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0004402	molecular_function	histone acetyltransferase activity
B	0006355	biological_process	regulation of DNA-templated transcription
C	0004402	molecular_function	histone acetyltransferase activity
C	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue 58N A 1201

Chain	Residue
A	LEU1109
A	PRO1110
A	VAL1115
A	LEU1120
A	ASN1168
A	VAL1174
A	HOH1331

---

site_id	AC2
Number of Residues	7
Details	binding site for residue 58N B 1201

Chain	Residue
B	LEU1120
B	TYR1125
B	ASN1168
B	HOH1318
B	HOH1325
B	PRO1110
B	VAL1115

---

site_id	AC3
Number of Residues	7
Details	binding site for residue 58N C 1201

Chain	Residue
A	GLN1148
C	LEU1109
C	PRO1110
C	VAL1115
C	LEU1120
C	ASN1168
C	HOH1347

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY

Chain	Residue	Details
A	SER1108-TYR1167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	321
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	138
Details	Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	54
Details	Region: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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