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5DAK

Crystal Structure of human Glutathione Transferase Pi complexed with a metalloid in the absence of Glutathione

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000302biological_processresponse to reactive oxygen species
A0002674biological_processnegative regulation of acute inflammatory response
A0004364molecular_functionglutathione transferase activity
A0004602molecular_functionglutathione peroxidase activity
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006693biological_processprostaglandin metabolic process
A0006749biological_processglutathione metabolic process
A0006805biological_processxenobiotic metabolic process
A0007417biological_processcentral nervous system development
A0008432molecular_functionJUN kinase binding
A0009636biological_processresponse to toxic substance
A0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
A0014003biological_processoligodendrocyte development
A0015643molecular_functiontoxic substance binding
A0016740molecular_functiontransferase activity
A0019901molecular_functionprotein kinase binding
A0030291molecular_functionprotein serine/threonine kinase inhibitor activity
A0031100biological_processanimal organ regeneration
A0031667biological_processresponse to nutrient levels
A0031982cellular_componentvesicle
A0032355biological_processresponse to estradiol
A0032691biological_processnegative regulation of interleukin-1 beta production
A0032720biological_processnegative regulation of tumor necrosis factor production
A0032869biological_processcellular response to insulin stimulus
A0032872biological_processregulation of stress-activated MAPK cascade
A0032873biological_processnegative regulation of stress-activated MAPK cascade
A0032930biological_processpositive regulation of superoxide anion generation
A0033591biological_processresponse to L-ascorbic acid
A0034774cellular_componentsecretory granule lumen
A0035726biological_processcommon myeloid progenitor cell proliferation
A0035730molecular_functionS-nitrosoglutathione binding
A0035731molecular_functiondinitrosyl-iron complex binding
A0035732biological_processnitric oxide storage
A0043066biological_processnegative regulation of apoptotic process
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0043200biological_processresponse to amino acid
A0043409biological_processnegative regulation of MAPK cascade
A0043651biological_processlinoleic acid metabolic process
A0045471biological_processresponse to ethanol
A0046329biological_processnegative regulation of JNK cascade
A0048147biological_processnegative regulation of fibroblast proliferation
A0051122biological_processhepoxilin biosynthetic process
A0070026molecular_functionnitric oxide binding
A0070062cellular_componentextracellular exosome
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0070664biological_processnegative regulation of leukocyte proliferation
A0071222biological_processcellular response to lipopolysaccharide
A0071364biological_processcellular response to epidermal growth factor stimulus
A0071385biological_processcellular response to glucocorticoid stimulus
A0071460biological_processcellular response to cell-matrix adhesion
A0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
A0071672biological_processnegative regulation of smooth muscle cell chemotaxis
A0097057cellular_componentTRAF2-GSTP1 complex
A0098869biological_processcellular oxidant detoxification
A1901687biological_processglutathione derivative biosynthetic process
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A1904813cellular_componentficolin-1-rich granule lumen
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000302biological_processresponse to reactive oxygen species
B0002674biological_processnegative regulation of acute inflammatory response
B0004364molecular_functionglutathione transferase activity
B0004602molecular_functionglutathione peroxidase activity
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006693biological_processprostaglandin metabolic process
B0006749biological_processglutathione metabolic process
B0006805biological_processxenobiotic metabolic process
B0007417biological_processcentral nervous system development
B0008432molecular_functionJUN kinase binding
B0009636biological_processresponse to toxic substance
B0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
B0014003biological_processoligodendrocyte development
B0015643molecular_functiontoxic substance binding
B0016740molecular_functiontransferase activity
B0019901molecular_functionprotein kinase binding
B0030291molecular_functionprotein serine/threonine kinase inhibitor activity
B0031100biological_processanimal organ regeneration
B0031667biological_processresponse to nutrient levels
B0031982cellular_componentvesicle
B0032355biological_processresponse to estradiol
B0032691biological_processnegative regulation of interleukin-1 beta production
B0032720biological_processnegative regulation of tumor necrosis factor production
B0032869biological_processcellular response to insulin stimulus
B0032872biological_processregulation of stress-activated MAPK cascade
B0032873biological_processnegative regulation of stress-activated MAPK cascade
B0032930biological_processpositive regulation of superoxide anion generation
B0033591biological_processresponse to L-ascorbic acid
B0034774cellular_componentsecretory granule lumen
B0035726biological_processcommon myeloid progenitor cell proliferation
B0035730molecular_functionS-nitrosoglutathione binding
B0035731molecular_functiondinitrosyl-iron complex binding
B0035732biological_processnitric oxide storage
B0043066biological_processnegative regulation of apoptotic process
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0043200biological_processresponse to amino acid
B0043409biological_processnegative regulation of MAPK cascade
B0043651biological_processlinoleic acid metabolic process
B0045471biological_processresponse to ethanol
B0046329biological_processnegative regulation of JNK cascade
B0048147biological_processnegative regulation of fibroblast proliferation
B0051122biological_processhepoxilin biosynthetic process
B0070026molecular_functionnitric oxide binding
B0070062cellular_componentextracellular exosome
B0070372biological_processregulation of ERK1 and ERK2 cascade
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0070664biological_processnegative regulation of leukocyte proliferation
B0071222biological_processcellular response to lipopolysaccharide
B0071364biological_processcellular response to epidermal growth factor stimulus
B0071385biological_processcellular response to glucocorticoid stimulus
B0071460biological_processcellular response to cell-matrix adhesion
B0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
B0071672biological_processnegative regulation of smooth muscle cell chemotaxis
B0097057cellular_componentTRAF2-GSTP1 complex
B0098869biological_processcellular oxidant detoxification
B1901687biological_processglutathione derivative biosynthetic process
B1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
B1904813cellular_componentficolin-1-rich granule lumen
B2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue MES A 301
ChainResidue
AALA22
ATRP28
AGLU197

site_idAC2
Number of Residues1
Detailsbinding site for residue ARS A 302
ChainResidue
ACYS101

site_idAC3
Number of Residues4
Detailsbinding site for residue MES B 301
ChainResidue
AHOH408
BTRP28
BPHE192
BGLU197

site_idAC4
Number of Residues1
Detailsbinding site for residue ARS B 302
ChainResidue
BCYS101

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518
ChainResidueDetails
BTYR7
BARG13
BTRP38
BLYS44
BGLN51
BGLN64

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by EGFR => ECO:0000269|PubMed:19254954
ChainResidueDetails
BTYR3
BTYR198

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR61

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P19157
ChainResidueDetails
BLYS102
BLYS115

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS127

234136

PDB entries from 2025-04-02

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