5DAH
Crystal structure of PZP domain of human AF10 protein fused with Histone H3 peptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | CYS25 |
| A | CYS28 |
| A | HIS52 |
| A | CYS55 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 302 |
| Chain | Residue |
| A | CYS42 |
| A | CYS47 |
| A | CYS68 |
| A | CYS71 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 303 |
| Chain | Residue |
| A | CYS85 |
| A | HIS102 |
| A | CYS105 |
| A | CYS82 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 304 |
| Chain | Residue |
| A | CYS137 |
| A | CYS140 |
| A | HIS167 |
| A | CYS170 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 305 |
| Chain | Residue |
| A | CYS157 |
| A | CYS162 |
| A | CYS194 |
| A | HIS197 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | ARG145 |
| A | GLU146 |
| A | SER147 |
| A | LYS148 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 307 |
| Chain | Residue |
| A | ALA78 |
| A | HIS160 |
| A | GLY161 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | CYS25 |
| B | CYS28 |
| B | HIS52 |
| B | CYS55 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 302 |
| Chain | Residue |
| B | CYS42 |
| B | CYS47 |
| B | CYS68 |
| B | CYS71 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 303 |
| Chain | Residue |
| B | CYS82 |
| B | CYS85 |
| B | HIS102 |
| B | CYS105 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 304 |
| Chain | Residue |
| B | CYS137 |
| B | CYS140 |
| B | HIS167 |
| B | CYS170 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 305 |
| Chain | Residue |
| B | CYS157 |
| B | CYS162 |
| B | CYS194 |
| B | HIS197 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 306 |
| Chain | Residue |
| B | ARG145 |
| B | GLU146 |
| B | SER147 |
| B | LYS148 |
Functional Information from PROSITE/UniProt
| site_id | PS01359 |
| Number of Residues | 47 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. CcvCsdergwaenpl..................................VyCdghgCsva.VHqaCygivqvptgp...................................WfCrkC |
| Chain | Residue | Details |
| A | CYS25-CYS71 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 104 |
| Details | Zinc finger: {"description":"PHD-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 66 |
| Details | Zinc finger: {"description":"C2HC pre-PHD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01146","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 63 |
| Details | Zinc finger: {"description":"PHD-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01146","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 84 |
| Details | Region: {"description":"Required for interaction with histone H3","evidences":[{"source":"PubMed","id":"26439302","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Citrulline","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5","evidences":[{"source":"PubMed","id":"10464286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11856369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15684425","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"27595565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29053958","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
