5D8N
Tomato leucine aminopeptidase mutant - K354E
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006457 | biological_process | protein folding |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0009507 | cellular_component | chloroplast |
| A | 0009611 | biological_process | response to wounding |
| A | 0009617 | biological_process | response to bacterium |
| A | 0009625 | biological_process | response to insect |
| A | 0009753 | biological_process | response to jasmonic acid |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019538 | biological_process | protein metabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0034214 | biological_process | protein hexamerization |
| A | 0034605 | biological_process | cellular response to heat |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043171 | biological_process | peptide catabolic process |
| A | 0044183 | molecular_function | protein folding chaperone |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006457 | biological_process | protein folding |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0009507 | cellular_component | chloroplast |
| B | 0009611 | biological_process | response to wounding |
| B | 0009617 | biological_process | response to bacterium |
| B | 0009625 | biological_process | response to insect |
| B | 0009753 | biological_process | response to jasmonic acid |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019538 | biological_process | protein metabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0034214 | biological_process | protein hexamerization |
| B | 0034605 | biological_process | cellular response to heat |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043171 | biological_process | peptide catabolic process |
| B | 0044183 | molecular_function | protein folding chaperone |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006457 | biological_process | protein folding |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0009507 | cellular_component | chloroplast |
| C | 0009611 | biological_process | response to wounding |
| C | 0009617 | biological_process | response to bacterium |
| C | 0009625 | biological_process | response to insect |
| C | 0009753 | biological_process | response to jasmonic acid |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0019538 | biological_process | protein metabolic process |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0034214 | biological_process | protein hexamerization |
| C | 0034605 | biological_process | cellular response to heat |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043171 | biological_process | peptide catabolic process |
| C | 0044183 | molecular_function | protein folding chaperone |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 601 |
| Chain | Residue |
| A | LYS342 |
| A | MET368 |
| A | GLY369 |
| A | GLY370 |
| A | THR454 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 602 |
| Chain | Residue |
| A | ARG494 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 603 |
| Chain | Residue |
| A | ALA428 |
| A | GLY430 |
| A | ARG431 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 604 |
| Chain | Residue |
| A | ILE74 |
| A | HOH705 |
| A | HOH787 |
| A | HOH862 |
| A | HOH945 |
| A | HOH1085 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 605 |
| Chain | Residue |
| A | VAL262 |
| A | ALA264 |
| A | HOH748 |
| A | HOH893 |
| A | HOH960 |
| A | HOH997 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 606 |
| Chain | Residue |
| A | SER290 |
| A | ASN292 |
| A | HIS323 |
| A | CYS325 |
| A | HOH824 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 601 |
| Chain | Residue |
| B | ARG494 |
| B | HOH792 |
| B | HOH819 |
| B | HOH901 |
| B | HOH925 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 602 |
| Chain | Residue |
| B | SER290 |
| B | ASN292 |
| B | HIS323 |
| B | CYS325 |
| B | HOH729 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 603 |
| Chain | Residue |
| B | ASP57 |
| B | THR58 |
| B | ASN267 |
| B | HOH707 |
| B | HOH738 |
| B | HOH804 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 604 |
| Chain | Residue |
| A | GLU129 |
| A | HOH756 |
| B | SER176 |
| B | HOH990 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 605 |
| Chain | Residue |
| B | LYS342 |
| B | GLY369 |
| B | GLY370 |
| B | THR454 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 606 |
| Chain | Residue |
| B | ALA428 |
| B | GLY430 |
| B | ARG431 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 607 |
| Chain | Residue |
| B | PRO473 |
| B | ASP475 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 608 |
| Chain | Residue |
| B | VAL262 |
| B | ALA264 |
| B | HOH715 |
| B | HOH762 |
| B | HOH980 |
| B | HOH1022 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 609 |
| Chain | Residue |
| B | ILE74 |
| B | HOH739 |
| B | HOH830 |
| B | HOH848 |
| B | HOH989 |
| B | HOH1149 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 610 |
| Chain | Residue |
| A | HOH973 |
| A | HOH1001 |
| B | HOH778 |
| B | HOH780 |
| B | HOH1063 |
| B | HOH1156 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 601 |
| Chain | Residue |
| C | ARG494 |
| C | HOH701 |
| C | HOH720 |
| C | HOH766 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 602 |
| Chain | Residue |
| C | ARG333 |
| C | THR335 |
| C | SER387 |
| C | ARG388 |
| C | ARG388 |
| C | HOH814 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 603 |
| Chain | Residue |
| C | TYR501 |
| C | SER504 |
| C | ASN519 |
| C | THR524 |
| C | HOH737 |
| C | HOH818 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 604 |
| Chain | Residue |
| C | LYS342 |
| C | GLY369 |
| C | GLY370 |
| C | THR454 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 605 |
| Chain | Residue |
| C | ALA428 |
| C | GLY430 |
| C | ARG431 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 606 |
| Chain | Residue |
| C | HOH952 |
| C | HOH955 |
| C | HOH1089 |
| C | ILE74 |
| C | HOH748 |
| C | HOH819 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 607 |
| Chain | Residue |
| C | VAL262 |
| C | ALA264 |
| C | HOH731 |
| C | HOH857 |
| C | HOH942 |
| C | HOH1013 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue ACT C 608 |
| Chain | Residue |
| C | SER290 |
| C | ASN292 |
| C | HIS323 |
| C | HOH871 |
Functional Information from PROSITE/UniProt
| site_id | PS00631 |
| Number of Residues | 8 |
| Details | CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL |
| Chain | Residue | Details |
| A | ASN425-LEU432 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24914976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KSI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
