5D8J
Development of a therapeutic monoclonal antibody targeting secreted aP2 to treat type 2 diabetes.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005324 | molecular_function | long-chain fatty acid transmembrane transporter activity |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009617 | biological_process | response to bacterium |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0015909 | biological_process | long-chain fatty acid transport |
| A | 0036041 | molecular_function | long-chain fatty acid binding |
| A | 0042632 | biological_process | cholesterol homeostasis |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| A | 0050872 | biological_process | white fat cell differentiation |
| A | 0050873 | biological_process | brown fat cell differentiation |
| A | 0051427 | molecular_function | hormone receptor binding |
| A | 0071285 | biological_process | cellular response to lithium ion |
| A | 0071356 | biological_process | cellular response to tumor necrosis factor |
| A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | LYS22 |
| A | PHE28 |
| A | ARG31 |
| L | SER93 |
| L | HIS94 |
| L | TYR95 |
Functional Information from PROSITE/UniProt
| site_id | PS00214 |
| Number of Residues | 18 |
| Details | FABP Cytosolic fatty-acid binding proteins signature. GTWkLvsSeNFDdYMKEV |
| Chain | Residue | Details |
| A | GLY7-VAL24 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR193-HIS199 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG127 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylcysteine => ECO:0000250|UniProtKB:P15090 |
| Chain | Residue | Details |
| A | CYS2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER13 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR20 |
