5D7G

Structure of human ATG5 E122D-ATG16L1 complex at 3.0 Angstroms

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000423	biological_process	mitophagy
A	0002376	biological_process	immune system process
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0005930	cellular_component	axoneme
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006995	biological_process	cellular response to nitrogen starvation
A	0010040	biological_process	response to iron(II) ion
A	0010508	biological_process	positive regulation of autophagy
A	0016020	cellular_component	membrane
A	0016236	biological_process	macroautophagy
A	0019776	molecular_function	Atg8-family ligase activity
A	0030424	cellular_component	axon
A	0030670	cellular_component	phagocytic vesicle membrane
A	0032480	biological_process	negative regulation of type I interferon production
A	0032991	cellular_component	protein-containing complex
A	0034045	cellular_component	phagophore assembly site membrane
A	0034274	cellular_component	Atg12-Atg5-Atg16 complex
A	0034727	biological_process	piecemeal microautophagy of the nucleus
A	0035973	biological_process	aggrephagy
A	0043066	biological_process	negative regulation of apoptotic process
A	0043069	biological_process	negative regulation of programmed cell death
A	0043687	biological_process	post-translational protein modification
A	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
A	0045202	cellular_component	synapse
A	0045824	biological_process	negative regulation of innate immune response
A	0050687	biological_process	negative regulation of defense response to virus
A	0061684	biological_process	chaperone-mediated autophagy
A	0061908	cellular_component	phagophore
A	0062029	biological_process	positive regulation of stress granule assembly
A	0071500	biological_process	cellular response to nitrosative stress
A	0098685	cellular_component	Schaffer collateral - CA1 synapse
A	0098794	cellular_component	postsynapse
A	0098930	biological_process	axonal transport
A	0098978	cellular_component	glutamatergic synapse
A	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
A	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
A	1901096	biological_process	regulation of autophagosome maturation
A	1902017	biological_process	regulation of cilium assembly
A	1902617	biological_process	response to fluoride
A	1904093	biological_process	negative regulation of autophagic cell death
A	1904973	biological_process	positive regulation of viral translation
A	1990234	cellular_component	transferase complex
C	0000045	biological_process	autophagosome assembly
C	0000423	biological_process	mitophagy
C	0002376	biological_process	immune system process
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005776	cellular_component	autophagosome
C	0005829	cellular_component	cytosol
C	0005930	cellular_component	axoneme
C	0006914	biological_process	autophagy
C	0006915	biological_process	apoptotic process
C	0006995	biological_process	cellular response to nitrogen starvation
C	0010040	biological_process	response to iron(II) ion
C	0010508	biological_process	positive regulation of autophagy
C	0016020	cellular_component	membrane
C	0016236	biological_process	macroautophagy
C	0019776	molecular_function	Atg8-family ligase activity
C	0030424	cellular_component	axon
C	0030670	cellular_component	phagocytic vesicle membrane
C	0032480	biological_process	negative regulation of type I interferon production
C	0032991	cellular_component	protein-containing complex
C	0034045	cellular_component	phagophore assembly site membrane
C	0034274	cellular_component	Atg12-Atg5-Atg16 complex
C	0034727	biological_process	piecemeal microautophagy of the nucleus
C	0035973	biological_process	aggrephagy
C	0043066	biological_process	negative regulation of apoptotic process
C	0043069	biological_process	negative regulation of programmed cell death
C	0043687	biological_process	post-translational protein modification
C	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
C	0045202	cellular_component	synapse
C	0045824	biological_process	negative regulation of innate immune response
C	0050687	biological_process	negative regulation of defense response to virus
C	0061684	biological_process	chaperone-mediated autophagy
C	0061908	cellular_component	phagophore
C	0062029	biological_process	positive regulation of stress granule assembly
C	0071500	biological_process	cellular response to nitrosative stress
C	0098685	cellular_component	Schaffer collateral - CA1 synapse
C	0098794	cellular_component	postsynapse
C	0098930	biological_process	axonal transport
C	0098978	cellular_component	glutamatergic synapse
C	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
C	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
C	1901096	biological_process	regulation of autophagosome maturation
C	1902017	biological_process	regulation of cilium assembly
C	1902617	biological_process	response to fluoride
C	1904093	biological_process	negative regulation of autophagic cell death
C	1904973	biological_process	positive regulation of viral translation
C	1990234	cellular_component	transferase complex
E	0000045	biological_process	autophagosome assembly
E	0000423	biological_process	mitophagy
E	0002376	biological_process	immune system process
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005776	cellular_component	autophagosome
E	0005829	cellular_component	cytosol
E	0005930	cellular_component	axoneme
E	0006914	biological_process	autophagy
E	0006915	biological_process	apoptotic process
E	0006995	biological_process	cellular response to nitrogen starvation
E	0010040	biological_process	response to iron(II) ion
E	0010508	biological_process	positive regulation of autophagy
E	0016020	cellular_component	membrane
E	0016236	biological_process	macroautophagy
E	0019776	molecular_function	Atg8-family ligase activity
E	0030424	cellular_component	axon
E	0030670	cellular_component	phagocytic vesicle membrane
E	0032480	biological_process	negative regulation of type I interferon production
E	0032991	cellular_component	protein-containing complex
E	0034045	cellular_component	phagophore assembly site membrane
E	0034274	cellular_component	Atg12-Atg5-Atg16 complex
E	0034727	biological_process	piecemeal microautophagy of the nucleus
E	0035973	biological_process	aggrephagy
E	0043066	biological_process	negative regulation of apoptotic process
E	0043069	biological_process	negative regulation of programmed cell death
E	0043687	biological_process	post-translational protein modification
E	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
E	0045202	cellular_component	synapse
E	0045824	biological_process	negative regulation of innate immune response
E	0050687	biological_process	negative regulation of defense response to virus
E	0061684	biological_process	chaperone-mediated autophagy
E	0061908	cellular_component	phagophore
E	0062029	biological_process	positive regulation of stress granule assembly
E	0071500	biological_process	cellular response to nitrosative stress
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098794	cellular_component	postsynapse
E	0098930	biological_process	axonal transport
E	0098978	cellular_component	glutamatergic synapse
E	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
E	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
E	1901096	biological_process	regulation of autophagosome maturation
E	1902017	biological_process	regulation of cilium assembly
E	1902617	biological_process	response to fluoride
E	1904093	biological_process	negative regulation of autophagic cell death
E	1904973	biological_process	positive regulation of viral translation
E	1990234	cellular_component	transferase complex
G	0000045	biological_process	autophagosome assembly
G	0000423	biological_process	mitophagy
G	0002376	biological_process	immune system process
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005776	cellular_component	autophagosome
G	0005829	cellular_component	cytosol
G	0005930	cellular_component	axoneme
G	0006914	biological_process	autophagy
G	0006915	biological_process	apoptotic process
G	0006995	biological_process	cellular response to nitrogen starvation
G	0010040	biological_process	response to iron(II) ion
G	0010508	biological_process	positive regulation of autophagy
G	0016020	cellular_component	membrane
G	0016236	biological_process	macroautophagy
G	0019776	molecular_function	Atg8-family ligase activity
G	0030424	cellular_component	axon
G	0030670	cellular_component	phagocytic vesicle membrane
G	0032480	biological_process	negative regulation of type I interferon production
G	0032991	cellular_component	protein-containing complex
G	0034045	cellular_component	phagophore assembly site membrane
G	0034274	cellular_component	Atg12-Atg5-Atg16 complex
G	0034727	biological_process	piecemeal microautophagy of the nucleus
G	0035973	biological_process	aggrephagy
G	0043066	biological_process	negative regulation of apoptotic process
G	0043069	biological_process	negative regulation of programmed cell death
G	0043687	biological_process	post-translational protein modification
G	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
G	0045202	cellular_component	synapse
G	0045824	biological_process	negative regulation of innate immune response
G	0050687	biological_process	negative regulation of defense response to virus
G	0061684	biological_process	chaperone-mediated autophagy
G	0061908	cellular_component	phagophore
G	0062029	biological_process	positive regulation of stress granule assembly
G	0071500	biological_process	cellular response to nitrosative stress
G	0098685	cellular_component	Schaffer collateral - CA1 synapse
G	0098794	cellular_component	postsynapse
G	0098930	biological_process	axonal transport
G	0098978	cellular_component	glutamatergic synapse
G	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
G	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
G	1901096	biological_process	regulation of autophagosome maturation
G	1902017	biological_process	regulation of cilium assembly
G	1902617	biological_process	response to fluoride
G	1904093	biological_process	negative regulation of autophagic cell death
G	1904973	biological_process	positive regulation of viral translation
G	1990234	cellular_component	transferase complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	120
Details	Region: {"description":"Interaction with ATG5","evidences":[{"source":"PubMed","id":"25484072","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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