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5D7F

X-ray structure of Ca(2+)-S100B with human RAGE-derived W72 peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0001726cellular_componentruffle
A0005102molecular_functionsignaling receptor binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005929cellular_componentcilium
A0007155biological_processcell adhesion
A0007409biological_processaxonogenesis
A0007417biological_processcentral nervous system development
A0007611biological_processlearning or memory
A0007613biological_processmemory
A0008270molecular_functionzinc ion binding
A0008284biological_processpositive regulation of cell population proliferation
A0008360biological_processregulation of cell shape
A0015630cellular_componentmicrotubule cytoskeleton
A0031643biological_processpositive regulation of myelination
A0036064cellular_componentciliary basal body
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0044548molecular_functionS100 protein binding
A0045471biological_processresponse to ethanol
A0045666biological_processpositive regulation of neuron differentiation
A0046872molecular_functionmetal ion binding
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048708biological_processastrocyte differentiation
A0050786molecular_functionRAGE receptor binding
A0050806biological_processpositive regulation of synaptic transmission
A0051384biological_processresponse to glucocorticoid
A0051597biological_processresponse to methylmercury
A0060291biological_processlong-term synaptic potentiation
A0071456biological_processcellular response to hypoxia
A0072347biological_processresponse to anesthetic
A0097490biological_processsympathetic neuron projection extension
A1990138biological_processneuron projection extension
A1990845biological_processadaptive thermogenesis
A2001015biological_processnegative regulation of skeletal muscle cell differentiation
B0001726cellular_componentruffle
B0005102molecular_functionsignaling receptor binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005929cellular_componentcilium
B0007155biological_processcell adhesion
B0007409biological_processaxonogenesis
B0007417biological_processcentral nervous system development
B0007611biological_processlearning or memory
B0007613biological_processmemory
B0008270molecular_functionzinc ion binding
B0008284biological_processpositive regulation of cell population proliferation
B0008360biological_processregulation of cell shape
B0015630cellular_componentmicrotubule cytoskeleton
B0031643biological_processpositive regulation of myelination
B0036064cellular_componentciliary basal body
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0044548molecular_functionS100 protein binding
B0045471biological_processresponse to ethanol
B0045666biological_processpositive regulation of neuron differentiation
B0046872molecular_functionmetal ion binding
B0048156molecular_functiontau protein binding
B0048168biological_processregulation of neuronal synaptic plasticity
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048708biological_processastrocyte differentiation
B0050786molecular_functionRAGE receptor binding
B0050806biological_processpositive regulation of synaptic transmission
B0051384biological_processresponse to glucocorticoid
B0051597biological_processresponse to methylmercury
B0060291biological_processlong-term synaptic potentiation
B0071456biological_processcellular response to hypoxia
B0072347biological_processresponse to anesthetic
B0097490biological_processsympathetic neuron projection extension
B1990138biological_processneuron projection extension
B1990845biological_processadaptive thermogenesis
B2001015biological_processnegative regulation of skeletal muscle cell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue CA A 801
ChainResidue
ASER19
AGLU22
AASP24
ALYS27
AGLU32
AHOH912

site_idAC2
Number of Residues6
Detailsbinding site for residue CA A 802
ChainResidue
AGLU68
AGLU73
AHOH948
AASP62
AASP64
AASP66

site_idAC3
Number of Residues4
Detailsbinding site for residue GOL A 803
ChainResidue
ALYS49
AGLU50
BGLY65
BASP66

site_idAC4
Number of Residues5
Detailsbinding site for residue GOL A 804
ChainResidue
AMET80
ATHR83
AHOH953
AHOH980
BHOH927

site_idAC5
Number of Residues4
Detailsbinding site for residue GOL A 805
ChainResidue
AGLU22
AGLY23
AGOL806
AHOH911

site_idAC6
Number of Residues5
Detailsbinding site for residue GOL A 806
ChainResidue
AGLY23
AGOL805
AHOH902
AHOH910
AHOH977

site_idAC7
Number of Residues9
Detailsbinding site for residue GOL A 807
ChainResidue
ALYS30
ASER31
ALYS34
AGLN51
AVAL54
AHOH901
AHOH950
AHOH991
BHOH938

site_idAC8
Number of Residues6
Detailsbinding site for residue CA B 801
ChainResidue
BSER19
BGLU22
BASP24
BLYS27
BGLU32
BHOH913

site_idAC9
Number of Residues6
Detailsbinding site for residue CA B 802
ChainResidue
BASP62
BASP64
BASP66
BGLU68
BGLU73
BHOH948

site_idAD1
Number of Residues7
Detailsbinding site for residue GOL B 803
ChainResidue
BLYS30
BSER31
BLYS34
BGLN51
BHOH903
BHOH947
BHOH964

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DNDGDGECDfqEF
ChainResidueDetails
AASP62-PHE74

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. VMetLDndgDgecDFqEFmaFV
ChainResidueDetails
AVAL57-VAL78

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT
ChainResidueDetails
AHIS16
AHIS26
AHIS86
AHIS91
BHIS16
BHIS26
BHIS86
BHIS91

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10
ChainResidueDetails
ASER19
BGLU32
AGLU22
AASP24
ALYS27
AGLU32
BSER19
BGLU22
BASP24
BLYS27

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10
ChainResidueDetails
AASP62
AASP66
AGLU68
AGLU73
BASP62
BASP66
BGLU68
BGLU73

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:20950652, ECO:0007744|PDB:2H61, ECO:0007744|PDB:3CZT, ECO:0007744|PDB:3D0Y, ECO:0007744|PDB:3D10
ChainResidueDetails
AASP64
BASP64

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N-acetylserine; alternate => ECO:0000250|UniProtKB:P02638
ChainResidueDetails
ASER2
BSER2

237735

PDB entries from 2025-06-18

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