5D70

Crystal structure of MOR03929, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001821	biological_process	histamine secretion
A	0005125	molecular_function	cytokine activity
A	0005129	molecular_function	granulocyte macrophage colony-stimulating factor receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006955	biological_process	immune response
A	0007165	biological_process	signal transduction
A	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
A	0008083	molecular_function	growth factor activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009966	biological_process	regulation of signal transduction
A	0010628	biological_process	positive regulation of gene expression
A	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
A	0030099	biological_process	myeloid cell differentiation
A	0030225	biological_process	macrophage differentiation
A	0030335	biological_process	positive regulation of cell migration
A	0032747	biological_process	positive regulation of interleukin-23 production
A	0034021	biological_process	response to silicon dioxide
A	0034405	biological_process	response to fluid shear stress
A	0038157	biological_process	granulocyte-macrophage colony-stimulating factor signaling pathway
A	0042045	biological_process	epithelial fluid transport
A	0043011	biological_process	myeloid dendritic cell differentiation
A	0045187	biological_process	regulation of circadian sleep/wake cycle, sleep
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0050793	biological_process	regulation of developmental process
A	0070665	biological_process	positive regulation of leukocyte proliferation
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071803	biological_process	positive regulation of podosome assembly
A	0097011	biological_process	cellular response to granulocyte macrophage colony-stimulating factor stimulus
A	0097028	biological_process	dendritic cell differentiation
A	0097696	biological_process	cell surface receptor signaling pathway via STAT
A	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 L 301

Chain	Residue
L	ASP1
L	LYS31
L	ASP92
L	SER93
L	HOH469
L	HOH487

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
L	TYR191-HIS197
H	TYR194-HIS200

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site_id	PS00702
Number of Residues	9
Details	GM_CSF Granulocyte-macrophage colony-stimulating factor signature. CPPTpETsC

Chain	Residue	Details
A	CYS88-CYS96

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) serine","evidences":[{"source":"PubMed","id":"1737041","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine; partial","evidences":[{"source":"PubMed","id":"1737041","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

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