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5D70

Crystal structure of MOR03929, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF

Functional Information from GO Data
ChainGOidnamespacecontents
A0001821biological_processhistamine secretion
A0001892biological_processembryonic placenta development
A0005125molecular_functioncytokine activity
A0005129molecular_functiongranulocyte macrophage colony-stimulating factor receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0006955biological_processimmune response
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008083molecular_functiongrowth factor activity
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0010468biological_processregulation of gene expression
A0010628biological_processpositive regulation of gene expression
A0010744biological_processpositive regulation of macrophage derived foam cell differentiation
A0030099biological_processmyeloid cell differentiation
A0030223biological_processneutrophil differentiation
A0030224biological_processmonocyte differentiation
A0030225biological_processmacrophage differentiation
A0030335biological_processpositive regulation of cell migration
A0030526cellular_componentgranulocyte macrophage colony-stimulating factor receptor complex
A0032747biological_processpositive regulation of interleukin-23 production
A0034021biological_processresponse to silicon dioxide
A0034405biological_processresponse to fluid shear stress
A0038157biological_processgranulocyte-macrophage colony-stimulating factor signaling pathway
A0042045biological_processepithelial fluid transport
A0042127biological_processregulation of cell population proliferation
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0043011biological_processmyeloid dendritic cell differentiation
A0043231cellular_componentintracellular membrane-bounded organelle
A0045187biological_processregulation of circadian sleep/wake cycle, sleep
A0045892biological_processnegative regulation of DNA-templated transcription
A0070665biological_processpositive regulation of leukocyte proliferation
A0071222biological_processcellular response to lipopolysaccharide
A0071803biological_processpositive regulation of podosome assembly
A0097011biological_processcellular response to granulocyte macrophage colony-stimulating factor stimulus
A0097028biological_processdendritic cell differentiation
A2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue SO4 L 301
ChainResidue
LASP1
LLYS31
LASP92
LSER93
LHOH469
LHOH487

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
ChainResidueDetails
LTYR191-HIS197
HTYR194-HIS200

site_idPS00702
Number of Residues9
DetailsGM_CSF Granulocyte-macrophage colony-stimulating factor signature. CPPTpETsC
ChainResidueDetails
ACYS88-CYS96

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:1737041
ChainResidueDetails
ASER5
ASER7
ASER9

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc...) threonine; partial => ECO:0000269|PubMed:1737041
ChainResidueDetails
ATHR10

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AASN27
AASN37

222415

PDB entries from 2024-07-10

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