5CVO

WDR48:USP46~ubiquitin ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0016579	biological_process	protein deubiquitination
B	0016787	molecular_function	hydrolase activity
B	0031647	biological_process	regulation of protein stability
B	0032228	biological_process	regulation of synaptic transmission, GABAergic
B	0045202	cellular_component	synapse
B	0046872	molecular_function	metal ion binding
B	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
B	0098978	cellular_component	glutamatergic synapse
B	0099149	biological_process	regulation of postsynaptic neurotransmitter receptor internalization
B	0101005	molecular_function	deubiquitinase activity
E	0004843	molecular_function	cysteine-type deubiquitinase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006508	biological_process	proteolysis
E	0008233	molecular_function	peptidase activity
E	0008234	molecular_function	cysteine-type peptidase activity
E	0016579	biological_process	protein deubiquitination
E	0016787	molecular_function	hydrolase activity
E	0031647	biological_process	regulation of protein stability
E	0032228	biological_process	regulation of synaptic transmission, GABAergic
E	0045202	cellular_component	synapse
E	0046872	molecular_function	metal ion binding
E	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
E	0098978	cellular_component	glutamatergic synapse
E	0099149	biological_process	regulation of postsynaptic neurotransmitter receptor internalization
E	0101005	molecular_function	deubiquitinase activity

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
C	LYS27-ASP52

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LISAssDtTVKVWNA

Chain	Residue	Details
A	LEU90-ALA104
A	VAL132-VAL146

---

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLvnfGNtCYCNSvLQ

Chain	Residue	Details
B	GLY36-GLN51

---

site_id	PS00973
Number of Residues	19
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YdLvAVvvHcGsgpnr.GHY

Chain	Residue	Details
B	TYR296-TYR314

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Repeat: {"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

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site_id	SWS_FT_FI2
Number of Residues	78
Details	Repeat: {"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

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---

site_id	SWS_FT_FI3
Number of Residues	78
Details	Repeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	78
Details	Repeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	78
Details	Repeat: {"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	78
Details	Repeat: {"description":"WD 6","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

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---

site_id	SWS_FT_FI7
Number of Residues	84
Details	Repeat: {"description":"WD 7","evidences":[{"evidenceCode":"ECO:0000255"}]}

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---

site_id	SWS_FT_FI8
Number of Residues	78
Details	Repeat: {"description":"WD 8","evidences":[{"evidenceCode":"ECO:0000255"}]}

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---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BH57","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26388029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22043315","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PDB","id":"5CVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L8H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	150
Details	Domain: {"description":"Ubiquitin-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

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