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5CVM

USP46~ubiquitin BEA covalent complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001662biological_processbehavioral fear response
A0004843molecular_functioncysteine-type deubiquitinase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
A0008343biological_processadult feeding behavior
A0016579biological_processprotein deubiquitination
A0031647biological_processregulation of protein stability
A0032228biological_processregulation of synaptic transmission, GABAergic
A0046872molecular_functionmetal ion binding
A0048149biological_processbehavioral response to ethanol
A0060013biological_processrighting reflex
A0101005molecular_functiondeubiquitinase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 1000
ChainResidue
ACYS182
ACYS185
ACYS229
ACYS232

Functional Information from PROSITE/UniProt
site_idPS00299
Number of Residues26
DetailsUBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD
ChainResidueDetails
BLYS27-ASP52

site_idPS00972
Number of Residues16
DetailsUSP_1 Ubiquitin specific protease (USP) domain signature 1. GLvnfGNtCYCNSvLQ
ChainResidueDetails
AGLY36-GLN51

site_idPS00973
Number of Residues19
DetailsUSP_2 Ubiquitin specific protease (USP) domain signature 2. YdLvAVvvHcGsgpnr.GHY
ChainResidueDetails
ATYR296-TYR314

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Interacts with activating enzyme
ChainResidueDetails
BARG54

site_idSWS_FT_FI2
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603
ChainResidueDetails
BLYS6

site_idSWS_FT_FI3
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144
ChainResidueDetails
ACYS182
BLYS11
BLYS48
ACYS232

site_idSWS_FT_FI4
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860
ChainResidueDetails
BLYS27

site_idSWS_FT_FI5
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127
ChainResidueDetails
BLYS29

site_idSWS_FT_FI6
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577
ChainResidueDetails
BLYS33

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PDB entries from 2024-11-06

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