5CRA

Structure of the SdeA DUB Domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016579	biological_process	protein deubiquitination
B	0016579	biological_process	protein deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 201

Chain	Residue
A	PRO58
A	HIS59
A	ARG60
B	ASP157
B	HIS158

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 202

Chain	Residue
B	HIS158
B	ASP159
A	ARG60
A	TYR90
A	HOH306
B	ASP157

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 203

Chain	Residue
A	ASP157
A	HIS158
A	ASP159
B	ARG60
B	TYR90

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 204

Chain	Residue
A	LEU82
A	LEU113
A	ASN114
A	MET115
A	HOH301

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 205

Chain	Residue
A	HIS16
A	ALA20
A	ARG21
B	LYS163

---

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 A 206

Chain	Residue
A	LYS84
A	THR85
A	SER111

---

site_id	AC7
Number of Residues	3
Details	binding site for residue GVE D 101

Chain	Residue
A	GLU9
A	HIS64
A	ASN114

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 B 201

Chain	Residue
A	ASP157
A	HIS158
B	PRO58
B	HIS59
B	ARG60

---

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 B 202

Chain	Residue
A	LYS163
B	HIS16
B	ALA20
B	ARG21

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 B 203

Chain	Residue
B	LEU82
B	LEU113
B	ASN114
B	MET115

---

site_id	AD2
Number of Residues	3
Details	binding site for residue GVE C 101

Chain	Residue
B	GLU9
B	HIS64
B	ASN114

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
D	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
D	ARG54
D	ARG72
C	ARG54
C	ARG72

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Essential for function

Chain	Residue	Details
D	HIS68
C	HIS68

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291

Chain	Residue	Details
D	SER65
C	SER65

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457

Chain	Residue	Details
D	THR66
C	THR66

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603

Chain	Residue	Details
D	LYS6
C	LYS6

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
D	LYS63
C	LYS63

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
D	LYS11
D	LYS48
C	LYS11
C	LYS48

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
D	LYS27
C	LYS27

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
D	LYS29
C	LYS29

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
D	LYS33
C	LYS33

---