5CQZ
Human cytosolic 5'-nucleotidase II in complex with 3-(3-Imidazol-1-ylphenyl)-N-(9H-purin-6-yl)benzamide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000255 | biological_process | allantoin metabolic process |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006204 | biological_process | IMP catabolic process |
A | 0008253 | molecular_function | 5'-nucleotidase activity |
A | 0009117 | biological_process | nucleotide metabolic process |
A | 0016740 | molecular_function | transferase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0046037 | biological_process | GMP metabolic process |
A | 0046040 | biological_process | IMP metabolic process |
A | 0046054 | biological_process | dGMP metabolic process |
A | 0046085 | biological_process | adenosine metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0050146 | molecular_function | nucleoside phosphotransferase activity |
A | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
A | 0050484 | molecular_function | GMP 5'-nucleotidase activity |
A | 0050689 | biological_process | negative regulation of defense response to virus by host |
A | 0061630 | molecular_function | ubiquitin protein ligase activity |
A | 0070936 | biological_process | protein K48-linked ubiquitination |
A | 0106411 | molecular_function | XMP 5'-nucleosidase activity |
B | 0000255 | biological_process | allantoin metabolic process |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006204 | biological_process | IMP catabolic process |
B | 0008253 | molecular_function | 5'-nucleotidase activity |
B | 0009117 | biological_process | nucleotide metabolic process |
B | 0016740 | molecular_function | transferase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0046037 | biological_process | GMP metabolic process |
B | 0046040 | biological_process | IMP metabolic process |
B | 0046054 | biological_process | dGMP metabolic process |
B | 0046085 | biological_process | adenosine metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0050146 | molecular_function | nucleoside phosphotransferase activity |
B | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
B | 0050484 | molecular_function | GMP 5'-nucleotidase activity |
B | 0050689 | biological_process | negative regulation of defense response to virus by host |
B | 0061630 | molecular_function | ubiquitin protein ligase activity |
B | 0070936 | biological_process | protein K48-linked ubiquitination |
B | 0106411 | molecular_function | XMP 5'-nucleosidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue GOL A 601 |
Chain | Residue |
A | GLU378 |
A | TRP382 |
A | TYR434 |
A | SER439 |
A | PHE441 |
A | ARG442 |
B | HIS486 |
B | GLU487 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue GOL A 602 |
Chain | Residue |
A | TYR475 |
A | LEU476 |
A | ARG478 |
B | ASP396 |
B | ALA400 |
A | LYS26 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue SO4 A 603 |
Chain | Residue |
A | ASP52 |
A | MET53 |
A | ASP54 |
A | THR249 |
A | ASN250 |
A | LYS292 |
A | MG610 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 604 |
Chain | Residue |
A | GLY130 |
A | PRO131 |
A | ARG134 |
A | LYS140 |
B | LYS344 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 605 |
Chain | Residue |
A | GLN377 |
A | GLU378 |
A | TYR434 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 606 |
Chain | Residue |
A | PHE191 |
A | SER193 |
A | VAL301 |
A | LEU302 |
A | THR316 |
A | THR318 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 607 |
Chain | Residue |
A | ASP289 |
A | GLY310 |
A | LEU312 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 608 |
Chain | Residue |
A | THR147 |
A | GLU148 |
A | TYR151 |
A | ARG195 |
A | PHE198 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue SO4 A 609 |
Chain | Residue |
A | GLU487 |
A | SER488 |
A | VAL490 |
B | TRP382 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue MG A 610 |
Chain | Residue |
A | ASP52 |
A | ASP54 |
A | ASP351 |
A | SO4603 |
A | HOH729 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue 53O A 612 |
Chain | Residue |
A | SER40 |
A | ARG478 |
B | GLN420 |
B | SER445 |
B | ARG446 |
site_id | AD3 |
Number of Residues | 8 |
Details | binding site for residue GOL B 601 |
Chain | Residue |
A | HIS486 |
A | GLU487 |
B | GLU378 |
B | TRP382 |
B | TYR434 |
B | SER439 |
B | PHE441 |
B | ARG442 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue GOL B 602 |
Chain | Residue |
A | ASP396 |
A | ALA400 |
B | LYS26 |
B | TYR475 |
B | LEU476 |
B | ARG478 |
site_id | AD5 |
Number of Residues | 7 |
Details | binding site for residue SO4 B 603 |
Chain | Residue |
B | ASP52 |
B | MET53 |
B | ASP54 |
B | THR249 |
B | ASN250 |
B | LYS292 |
B | MG607 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue SO4 B 604 |
Chain | Residue |
A | LYS344 |
B | GLY130 |
B | PRO131 |
B | ARG134 |
B | LYS140 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue SO4 B 605 |
Chain | Residue |
B | PHE157 |
B | ARG202 |
B | VAL205 |
B | ASP206 |
B | HIS209 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 606 |
Chain | Residue |
B | LEU483 |
B | GLU487 |
B | SER488 |
B | VAL490 |
site_id | AD9 |
Number of Residues | 5 |
Details | binding site for residue MG B 607 |
Chain | Residue |
B | ASP52 |
B | ASP54 |
B | ASP351 |
B | SO4603 |
B | HOH703 |
site_id | AE1 |
Number of Residues | 1 |
Details | binding site for residue MG B 608 |
Chain | Residue |
B | TYR457 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue 53O B 609 |
Chain | Residue |
A | SER445 |
A | ARG446 |
B | SER40 |
B | ARG478 |
A | GLN420 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile => ECO:0000305|PubMed:21396942 |
Chain | Residue | Details |
A | ASP52 | |
B | ASP52 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:21396942 |
Chain | Residue | Details |
A | ASP54 | |
B | ASP54 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17405878, ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2J2C, ECO:0007744|PDB:2JC9, ECO:0007744|PDB:2JCM, ECO:0007744|PDB:2XCV, ECO:0007744|PDB:2XCW, ECO:0007744|PDB:2XJB, ECO:0007744|PDB:2XJC, ECO:0007744|PDB:2XJD, ECO:0007744|PDB:2XJE |
Chain | Residue | Details |
A | ASP52 | |
A | ASP54 | |
B | ASP52 | |
B | ASP54 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2XJB |
Chain | Residue | Details |
A | ARG144 | |
A | ARG456 | |
B | ARG144 | |
B | ARG456 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2XJC |
Chain | Residue | Details |
A | ASN154 | |
A | LYS362 | |
A | GLN453 | |
A | TYR457 | |
B | ASN154 | |
B | LYS362 | |
B | GLN453 | |
B | TYR457 |
site_id | SWS_FT_FI6 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2XCV, ECO:0007744|PDB:2XCW |
Chain | Residue | Details |
A | ARG202 | |
B | LYS215 | |
B | THR249 | |
B | ASN250 | |
B | SER251 | |
B | LYS292 | |
A | ASP206 | |
A | LYS215 | |
A | THR249 | |
A | ASN250 | |
A | SER251 | |
A | LYS292 | |
B | ARG202 | |
B | ASP206 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17405878, ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2J2C, ECO:0007744|PDB:2JC9, ECO:0007744|PDB:2JCM |
Chain | Residue | Details |
A | ASP351 | |
B | ASP351 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17405878, ECO:0007744|PDB:2JC9 |
Chain | Residue | Details |
A | MET436 | |
B | MET436 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER418 | |
A | SER511 | |
B | SER418 | |
B | SER511 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
A | SER502 | |
B | SER502 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q3V1L4 |
Chain | Residue | Details |
A | SER527 | |
B | SER527 |