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5CPE

Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand

Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue EDO A 201
ChainResidue
AASN130
APHE133
AGLU154

site_idAC2
Number of Residues5
Detailsbinding site for residue EDO A 202
ChainResidue
APRO86
AASP106
AGLY108
ATHR109
AHOH303

site_idAC3
Number of Residues10
Detailsbinding site for residue EB2 A 203
ChainResidue
APRO82
APHE83
AVAL87
ALEU92
AASN140
AMET149
AHOH309
AHOH315
AHOH386
ATRP81

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues106
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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