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5CM8

Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral

Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0007264biological_processsmall GTPase-mediated signal transduction
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007265biological_processRas protein signal transduction
B0007298biological_processborder follicle cell migration
B0007464biological_processR3/R4 cell fate commitment
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0022604biological_processregulation of cell morphogenesis
B0030165molecular_functionPDZ domain binding
B0031623biological_processreceptor internalization
B0032154cellular_componentcleavage furrow
B0045087biological_processinnate immune response
B0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
B0045824biological_processnegative regulation of innate immune response
B0046329biological_processnegative regulation of JNK cascade
B0050829biological_processdefense response to Gram-negative bacterium
B0090543cellular_componentFlemming body
B2000648biological_processpositive regulation of stem cell proliferation
Functional Information from PROSITE/UniProt
site_idPS00720
Number of Residues31
DetailsRASGEF Ras Guanine-nucleotide exchange factors domain signature. VPYlGtfLkDLvmldaaskdelengy....................INFdK
ChainResidueDetails
AVAL429-LYS459

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BGLY18
BASP65
BASN124

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250
ChainResidueDetails
BCYS198

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250
ChainResidueDetails
BCYS198

226707

PDB entries from 2024-10-30

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