5CKV
DAHP synthase from Mycobacterium tuberculosis, fully inhibited by tyrosine, phenylalanine, and tryptophan
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051260 | biological_process | protein homooligomerization |
| B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051260 | biological_process | protein homooligomerization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 501 |
| Chain | Residue |
| A | ALA141 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | ARG135 |
| A | SER136 |
| A | ARG284 |
| A | LYS380 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | ASP138 |
| A | ARG145 |
| A | ARG148 |
| A | HIS164 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | GLY282 |
| A | GLU283 |
| A | ARG284 |
| A | LYS306 |
| A | ARG337 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | GLN70 |
| A | VAL121 |
| A | VAL122 |
| A | GLU242 |
| A | TRP507 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | GLU63 |
| A | ARG184 |
| A | THR187 |
| A | GLU242 |
| A | ILE243 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue TRP A 507 |
| Chain | Residue |
| A | VAL111 |
| A | LYS123 |
| A | ALA192 |
| A | ASN237 |
| A | THR240 |
| A | GOL505 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 508 |
| Chain | Residue |
| A | CYS87 |
| A | HIS369 |
| A | GLU411 |
| A | ASP441 |
| A | HOH604 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue PHE A 509 |
| Chain | Residue |
| A | PHE91 |
| A | ARG171 |
| A | ALA174 |
| A | ASN175 |
| B | VAL5 |
| B | VAL55 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 501 |
| Chain | Residue |
| B | LEU18 |
| B | ARG23 |
| B | ALA159 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue MN B 502 |
| Chain | Residue |
| B | CYS87 |
| B | HIS369 |
| B | GLU411 |
| B | ASP441 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | GLY282 |
| B | GLU283 |
| B | ARG284 |
| B | LYS306 |
| B | ARG337 |
| B | HIS369 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| B | ARG135 |
| B | SER136 |
| B | ALA137 |
| B | ARG284 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue GOL B 505 |
| Chain | Residue |
| A | GLN36 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 506 |
| Chain | Residue |
| B | LEU30 |
| B | ALA34 |
| B | ASP253 |
| B | ARG256 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 507 |
| Chain | Residue |
| A | ASP27 |
| A | ALA28 |
| B | ARG25 |
| B | GLN297 |
| B | VAL298 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue TYR B 508 |
| Chain | Residue |
| B | PRO16 |
| B | LEU18 |
| B | ARG23 |
| B | GLU53 |
| B | ARG256 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue TRP B 509 |
| Chain | Residue |
| B | VAL111 |
| B | LYS123 |
| B | ALA192 |
| B | CYS231 |
| B | ASN237 |
| B | LEU238 |
| B | THR240 |
| B | ALA241 |
| B | HOH606 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue PHE B 510 |
| Chain | Residue |
| A | ILE9 |
| A | TYR173 |
| B | PHE91 |
| B | ARG171 |
| B | ASN175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16288916, ECO:0007744|PDB:2B7O |
| Chain | Residue | Details |
| A | CYS87 | |
| B | ARG126 | |
| B | GLU283 | |
| B | LYS306 | |
| B | ARG337 | |
| B | HIS369 | |
| B | GLU411 | |
| B | ASP441 | |
| A | ARG126 | |
| A | GLU283 | |
| A | LYS306 | |
| A | ARG337 | |
| A | HIS369 | |
| A | GLU411 | |
| A | ASP441 | |
| B | CYS87 |
