5CIY
Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 24 |
Details | binding site for residue SAH A 401 |
Chain | Residue |
A | PHE18 |
A | ASP60 |
A | ILE61 |
A | GLY78 |
A | PRO80 |
A | TYR285 |
A | ASN304 |
A | SER305 |
A | VAL306 |
A | HOH574 |
A | HOH621 |
A | ALA19 |
A | HOH650 |
A | HOH665 |
A | HOH754 |
A | HOH783 |
A | HOH838 |
A | GLY20 |
A | LEU21 |
A | GLY23 |
A | ASN39 |
A | GLU40 |
A | TRP41 |
A | ASP42 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue SO4 A 402 |
Chain | Residue |
A | PRO198 |
A | ASP199 |
A | HOH513 |
A | HOH553 |
A | HOH636 |
A | HOH685 |
A | HOH686 |
A | HOH776 |
A | HOH780 |
site_id | AC3 |
Number of Residues | 10 |
Details | binding site for residue SO4 A 403 |
Chain | Residue |
A | LYS193 |
A | ARG245 |
A | LYS290 |
A | HOH532 |
A | HOH587 |
A | HOH608 |
A | HOH627 |
A | HOH666 |
A | HOH711 |
A | HOH791 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 404 |
Chain | Residue |
A | PRO286 |
A | ASP287 |
A | SER288 |
A | HOH519 |
A | HOH547 |
A | HOH810 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 405 |
Chain | Residue |
A | ILE219 |
A | GLU220 |
A | GLN221 |
A | HOH520 |
A | HOH746 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 406 |
Chain | Residue |
A | LYS114 |
A | ARG172 |
A | HOH813 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 407 |
Chain | Residue |
A | LEU196 |
A | PRO198 |
A | ARG281 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 408 |
Chain | Residue |
A | ASN141 |
A | SER146 |
A | PHE147 |
A | HOH515 |
A | HOH573 |
A | HOH580 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 409 |
Chain | Residue |
A | TRP41 |
A | HOH523 |
A | HOH691 |
Functional Information from PROSITE/UniProt
site_id | PS00094 |
Number of Residues | 13 |
Details | C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DiLcaGfPCqAFS |
Chain | Residue | Details |
A | ASP73-SER85 |
site_id | PS00095 |
Number of Residues | 19 |
Details | C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. KqfGNSVvInVlqyIaynI |
Chain | Residue | Details |
A | LYS300-ILE318 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:7899082 |
Chain | Residue | Details |
A | CYS81 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 293 |
Chain | Residue | Details |
A | CYS81 | covalently attached, hydrogen bond acceptor, nucleofuge, nucleophile, polar interaction, proton acceptor, proton donor |
A | GLU119 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond acceptor, increase electrophilicity |
A | ARG163 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, increase electrophilicity |
A | ARG165 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, increase electrophilicity |