5CIY
Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003886 | molecular_function | DNA (cytosine-5-)-methyltransferase activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009307 | biological_process | DNA restriction-modification system |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue SAH A 401 |
| Chain | Residue |
| A | PHE18 |
| A | ASP60 |
| A | ILE61 |
| A | GLY78 |
| A | PRO80 |
| A | TYR285 |
| A | ASN304 |
| A | SER305 |
| A | VAL306 |
| A | HOH574 |
| A | HOH621 |
| A | ALA19 |
| A | HOH650 |
| A | HOH665 |
| A | HOH754 |
| A | HOH783 |
| A | HOH838 |
| A | GLY20 |
| A | LEU21 |
| A | GLY23 |
| A | ASN39 |
| A | GLU40 |
| A | TRP41 |
| A | ASP42 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | PRO198 |
| A | ASP199 |
| A | HOH513 |
| A | HOH553 |
| A | HOH636 |
| A | HOH685 |
| A | HOH686 |
| A | HOH776 |
| A | HOH780 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | LYS193 |
| A | ARG245 |
| A | LYS290 |
| A | HOH532 |
| A | HOH587 |
| A | HOH608 |
| A | HOH627 |
| A | HOH666 |
| A | HOH711 |
| A | HOH791 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | PRO286 |
| A | ASP287 |
| A | SER288 |
| A | HOH519 |
| A | HOH547 |
| A | HOH810 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | ILE219 |
| A | GLU220 |
| A | GLN221 |
| A | HOH520 |
| A | HOH746 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | LYS114 |
| A | ARG172 |
| A | HOH813 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 407 |
| Chain | Residue |
| A | LEU196 |
| A | PRO198 |
| A | ARG281 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 408 |
| Chain | Residue |
| A | ASN141 |
| A | SER146 |
| A | PHE147 |
| A | HOH515 |
| A | HOH573 |
| A | HOH580 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 409 |
| Chain | Residue |
| A | TRP41 |
| A | HOH523 |
| A | HOH691 |
Functional Information from PROSITE/UniProt
| site_id | PS00094 |
| Number of Residues | 13 |
| Details | C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DiLcaGfPCqAFS |
| Chain | Residue | Details |
| A | ASP73-SER85 |
| site_id | PS00095 |
| Number of Residues | 19 |
| Details | C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. KqfGNSVvInVlqyIaynI |
| Chain | Residue | Details |
| A | LYS300-ILE318 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 313 |
| Details | Domain: {"description":"SAM-dependent MTase C5-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"7899082","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 293 |
| Chain | Residue | Details |
| A | CYS81 | covalently attached, hydrogen bond acceptor, nucleofuge, nucleophile, polar interaction, proton acceptor, proton donor |
| A | GLU119 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond acceptor, increase electrophilicity |
| A | ARG163 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, increase electrophilicity |
| A | ARG165 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, increase electrophilicity |
