5CIF
Complex of yeast cytochrome c peroxidase (W191F) with iso-1 cytochrome c
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0020037 | molecular_function | heme binding |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005758 | cellular_component | mitochondrial intermembrane space |
| B | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| B | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1901612 | molecular_function | cardiolipin binding |
| C | 0004601 | molecular_function | peroxidase activity |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0020037 | molecular_function | heme binding |
| C | 0034599 | biological_process | cellular response to oxidative stress |
| D | 0005515 | molecular_function | protein binding |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005758 | cellular_component | mitochondrial intermembrane space |
| D | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| D | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| D | 0009055 | molecular_function | electron transfer activity |
| D | 0020037 | molecular_function | heme binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 1901612 | molecular_function | cardiolipin binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue HEC A 301 |
| Chain | Residue |
| A | PRO44 |
| A | LYS179 |
| A | THR180 |
| A | HIS181 |
| A | ASN184 |
| A | SER185 |
| A | LEU232 |
| A | THR234 |
| A | PHE266 |
| A | HOH491 |
| A | HOH506 |
| A | ARG48 |
| A | TRP51 |
| A | ASP146 |
| A | MET172 |
| A | ALA174 |
| A | HIS175 |
| A | LEU177 |
| A | GLY178 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | binding site for residue HEC B 201 |
| Chain | Residue |
| A | ALA193 |
| A | ALA194 |
| B | ARG13 |
| B | CYS14 |
| B | CYS17 |
| B | HIS18 |
| B | VAL28 |
| B | GLY29 |
| B | LEU32 |
| B | SER40 |
| B | GLY41 |
| B | TYR46 |
| B | TYR48 |
| B | THR49 |
| B | ASN52 |
| B | TRP59 |
| B | MET64 |
| B | TYR67 |
| B | LEU68 |
| B | THR78 |
| B | LYS79 |
| B | MET80 |
| B | PHE82 |
| B | LEU94 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | binding site for residue HEC C 301 |
| Chain | Residue |
| C | PRO44 |
| C | VAL45 |
| C | ARG48 |
| C | TRP51 |
| C | PRO145 |
| C | ASP146 |
| C | ALA147 |
| C | MET172 |
| C | ALA174 |
| C | HIS175 |
| C | LEU177 |
| C | GLY178 |
| C | LYS179 |
| C | THR180 |
| C | HIS181 |
| C | ASN184 |
| C | SER185 |
| C | LEU232 |
| C | THR234 |
| C | PHE266 |
| C | HOH461 |
| C | HOH514 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | binding site for residue HEC D 201 |
| Chain | Residue |
| D | ARG13 |
| D | CYS14 |
| D | CYS17 |
| D | HIS18 |
| D | VAL28 |
| D | LEU32 |
| D | ILE35 |
| D | SER40 |
| D | GLY41 |
| D | TYR46 |
| D | TYR48 |
| D | THR49 |
| D | ASN52 |
| D | TYR67 |
| D | LEU68 |
| D | THR78 |
| D | LYS79 |
| D | MET80 |
| D | PHE82 |
| D | LEU94 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: covalent => ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0007744|PDB:1KYO, ECO:0007744|PDB:3CX5 |
| Chain | Residue | Details |
| B | CYS14 | |
| B | CYS17 | |
| D | CYS14 | |
| D | CYS17 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0007744|PDB:1KYO, ECO:0007744|PDB:3CX5 |
| Chain | Residue | Details |
| B | HIS18 | |
| B | MET80 | |
| D | HIS18 | |
| D | MET80 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine; by CTM1 => ECO:0000269|PubMed:10791961, ECO:0000269|PubMed:11880631, ECO:0007744|PDB:1KYO |
| Chain | Residue | Details |
| B | LYS72 | |
| D | LYS72 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000269|PubMed:10821864, ECO:0000269|PubMed:18390544 |
| Chain | Residue | Details |
| B | LYS73 | |
| D | LYS73 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | TYR153 | |
| C | TYR153 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 709 |
| Chain | Residue | Details |
| A | ARG48 | electrostatic stabiliser |
| A | HIS52 | electrostatic stabiliser, proton acceptor, proton donor |
| A | PHE191 | single electron acceptor, single electron donor |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 709 |
| Chain | Residue | Details |
| C | ARG48 | electrostatic stabiliser |
| C | HIS52 | electrostatic stabiliser, proton acceptor, proton donor |
| C | PHE191 | single electron acceptor, single electron donor |
