Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5CHF

Crystal structure of murine ISG15 in space group P21212

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002682	biological_process	regulation of immune system process
A	0003735	molecular_function	structural constituent of ribosome
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0007229	biological_process	integrin-mediated signaling pathway
A	0009615	biological_process	response to virus
A	0009617	biological_process	response to bacterium
A	0019941	biological_process	modification-dependent protein catabolic process
A	0022626	cellular_component	cytosolic ribosome
A	0030501	biological_process	positive regulation of bone mineralization
A	0031386	molecular_function	protein tag activity
A	0031397	biological_process	negative regulation of protein ubiquitination
A	0032020	biological_process	ISG15-protein conjugation
A	0032461	biological_process	positive regulation of protein oligomerization
A	0032649	biological_process	regulation of type II interferon production
A	0032728	biological_process	positive regulation of interferon-beta production
A	0032729	biological_process	positive regulation of type II interferon production
A	0032733	biological_process	positive regulation of interleukin-10 production
A	0034340	biological_process	response to type I interferon
A	0042742	biological_process	defense response to bacterium
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0051240	biological_process	positive regulation of multicellular organismal process
A	0051607	biological_process	defense response to virus
A	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
A	0070585	biological_process	protein localization to mitochondrion
B	0002682	biological_process	regulation of immune system process
B	0003735	molecular_function	structural constituent of ribosome
B	0005178	molecular_function	integrin binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0007229	biological_process	integrin-mediated signaling pathway
B	0009615	biological_process	response to virus
B	0009617	biological_process	response to bacterium
B	0019941	biological_process	modification-dependent protein catabolic process
B	0022626	cellular_component	cytosolic ribosome
B	0030501	biological_process	positive regulation of bone mineralization
B	0031386	molecular_function	protein tag activity
B	0031397	biological_process	negative regulation of protein ubiquitination
B	0032020	biological_process	ISG15-protein conjugation
B	0032461	biological_process	positive regulation of protein oligomerization
B	0032649	biological_process	regulation of type II interferon production
B	0032728	biological_process	positive regulation of interferon-beta production
B	0032729	biological_process	positive regulation of type II interferon production
B	0032733	biological_process	positive regulation of interleukin-10 production
B	0034340	biological_process	response to type I interferon
B	0042742	biological_process	defense response to bacterium
B	0045071	biological_process	negative regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0045648	biological_process	positive regulation of erythrocyte differentiation
B	0051240	biological_process	positive regulation of multicellular organismal process
B	0051607	biological_process	defense response to virus
B	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
B	0070585	biological_process	protein localization to mitochondrion
C	0002682	biological_process	regulation of immune system process
C	0003735	molecular_function	structural constituent of ribosome
C	0005178	molecular_function	integrin binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0007229	biological_process	integrin-mediated signaling pathway
C	0009615	biological_process	response to virus
C	0009617	biological_process	response to bacterium
C	0019941	biological_process	modification-dependent protein catabolic process
C	0022626	cellular_component	cytosolic ribosome
C	0030501	biological_process	positive regulation of bone mineralization
C	0031386	molecular_function	protein tag activity
C	0031397	biological_process	negative regulation of protein ubiquitination
C	0032020	biological_process	ISG15-protein conjugation
C	0032461	biological_process	positive regulation of protein oligomerization
C	0032649	biological_process	regulation of type II interferon production
C	0032728	biological_process	positive regulation of interferon-beta production
C	0032729	biological_process	positive regulation of type II interferon production
C	0032733	biological_process	positive regulation of interleukin-10 production
C	0034340	biological_process	response to type I interferon
C	0042742	biological_process	defense response to bacterium
C	0045071	biological_process	negative regulation of viral genome replication
C	0045087	biological_process	innate immune response
C	0045648	biological_process	positive regulation of erythrocyte differentiation
C	0051240	biological_process	positive regulation of multicellular organismal process
C	0051607	biological_process	defense response to virus
C	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
C	0070585	biological_process	protein localization to mitochondrion
D	0002682	biological_process	regulation of immune system process
D	0003735	molecular_function	structural constituent of ribosome
D	0005178	molecular_function	integrin binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0007229	biological_process	integrin-mediated signaling pathway
D	0009615	biological_process	response to virus
D	0009617	biological_process	response to bacterium
D	0019941	biological_process	modification-dependent protein catabolic process
D	0022626	cellular_component	cytosolic ribosome
D	0030501	biological_process	positive regulation of bone mineralization
D	0031386	molecular_function	protein tag activity
D	0031397	biological_process	negative regulation of protein ubiquitination
D	0032020	biological_process	ISG15-protein conjugation
D	0032461	biological_process	positive regulation of protein oligomerization
D	0032649	biological_process	regulation of type II interferon production
D	0032728	biological_process	positive regulation of interferon-beta production
D	0032729	biological_process	positive regulation of type II interferon production
D	0032733	biological_process	positive regulation of interleukin-10 production
D	0034340	biological_process	response to type I interferon
D	0042742	biological_process	defense response to bacterium
D	0045071	biological_process	negative regulation of viral genome replication
D	0045087	biological_process	innate immune response
D	0045648	biological_process	positive regulation of erythrocyte differentiation
D	0051240	biological_process	positive regulation of multicellular organismal process
D	0051607	biological_process	defense response to virus
D	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
D	0070585	biological_process	protein localization to mitochondrion
E	0002682	biological_process	regulation of immune system process
E	0003735	molecular_function	structural constituent of ribosome
E	0005178	molecular_function	integrin binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0007229	biological_process	integrin-mediated signaling pathway
E	0009615	biological_process	response to virus
E	0009617	biological_process	response to bacterium
E	0019941	biological_process	modification-dependent protein catabolic process
E	0022626	cellular_component	cytosolic ribosome
E	0030501	biological_process	positive regulation of bone mineralization
E	0031386	molecular_function	protein tag activity
E	0031397	biological_process	negative regulation of protein ubiquitination
E	0032020	biological_process	ISG15-protein conjugation
E	0032461	biological_process	positive regulation of protein oligomerization
E	0032649	biological_process	regulation of type II interferon production
E	0032728	biological_process	positive regulation of interferon-beta production
E	0032729	biological_process	positive regulation of type II interferon production
E	0032733	biological_process	positive regulation of interleukin-10 production
E	0034340	biological_process	response to type I interferon
E	0042742	biological_process	defense response to bacterium
E	0045071	biological_process	negative regulation of viral genome replication
E	0045087	biological_process	innate immune response
E	0045648	biological_process	positive regulation of erythrocyte differentiation
E	0051240	biological_process	positive regulation of multicellular organismal process
E	0051607	biological_process	defense response to virus
E	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
E	0070585	biological_process	protein localization to mitochondrion

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue GOL A 201

Chain	Residue
A	ALA33
A	PRO39
A	ALA40
A	GLY136
A	GLU137
E	GLU95

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL A 202

Chain	Residue
A	THR68
A	HIS47
A	GLN48
A	SER67

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 203

Chain	Residue
A	GLU95
B	LYS30
B	ALA40
B	PHE41

site_id	AC4
Number of Residues	10
Details	binding site for residue SO4 A 204

Chain	Residue
A	ARG44
A	GLN74
A	GLU78
A	HOH309
A	HOH310
A	HOH311
A	HOH312
A	HOH313
B	ARG127
B	PRO128

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL D 201

Chain	Residue
D	GLU95
D	PHE97
D	GLN100
D	LYS108
E	ALA33
E	GLN34

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 D 202

Chain	Residue
D	HIS149
D	HIS149

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 D 203

Chain	Residue
B	HIS47
B	GLN48
B	SER67
B	THR68
D	GLN74
D	ASN75
D	HOH309

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	296
Details	Domain: {"description":"Ubiquitin-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	10
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"18606809","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Site: {"description":"Interacts with activating enzyme","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)