5CD1
Structure of an asymmetric tetramer of human tRNA m1A58 methyltransferase in a complex with SAH and tRNA3Lys
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0006396 | biological_process | RNA processing |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008033 | biological_process | tRNA processing |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030488 | biological_process | tRNA methylation |
| A | 0031515 | cellular_component | tRNA (m1A) methyltransferase complex |
| A | 0032259 | biological_process | methylation |
| A | 0061953 | molecular_function | mRNA (adenine-N1-)-methyltransferase activity |
| A | 0160107 | molecular_function | tRNA (adenine(58)-N1)-methyltransferase activity |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008033 | biological_process | tRNA processing |
| B | 0030488 | biological_process | tRNA methylation |
| B | 0031515 | cellular_component | tRNA (m1A) methyltransferase complex |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0006396 | biological_process | RNA processing |
| D | 0006397 | biological_process | mRNA processing |
| D | 0008033 | biological_process | tRNA processing |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0030488 | biological_process | tRNA methylation |
| D | 0031515 | cellular_component | tRNA (m1A) methyltransferase complex |
| D | 0032259 | biological_process | methylation |
| D | 0061953 | molecular_function | mRNA (adenine-N1-)-methyltransferase activity |
| D | 0160107 | molecular_function | tRNA (adenine(58)-N1)-methyltransferase activity |
| E | 0003723 | molecular_function | RNA binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0006397 | biological_process | mRNA processing |
| E | 0008033 | biological_process | tRNA processing |
| E | 0030488 | biological_process | tRNA methylation |
| E | 0031515 | cellular_component | tRNA (m1A) methyltransferase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue SAH A 301 |
| Chain | Residue |
| A | THR84 |
| A | VAL117 |
| A | GLU135 |
| A | PHE136 |
| A | ARG140 |
| A | ASP163 |
| A | VAL164 |
| A | ASP181 |
| A | ILE182 |
| A | PRO183 |
| M | C56 |
| A | GLN85 |
| A | ILE86 |
| A | LEU87 |
| A | SER110 |
| A | GLY111 |
| A | THR112 |
| A | GLY115 |
| A | SER116 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue SAH D 301 |
| Chain | Residue |
| D | THR84 |
| D | GLN85 |
| D | ILE86 |
| D | LEU87 |
| D | SER110 |
| D | GLY111 |
| D | THR112 |
| D | GLY115 |
| D | SER116 |
| D | VAL117 |
| D | GLU135 |
| D | PHE136 |
| D | ARG140 |
| D | ASP163 |
| D | VAL164 |
| D | ASP181 |
| D | ILE182 |
| N | C56 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue NA M 101 |
| Chain | Residue |
| M | U8 |
| M | A9 |
| M | U12 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue NA N 101 |
| Chain | Residue |
| N | U8 |
| N | A9 |
| N | U12 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 140 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26470919","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CD1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26470919","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CD1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00952","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26470919","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CD1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
