5CBZ
AncMR DNA Binding Domain - (+)GRE Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0043565 | molecular_function | sequence-specific DNA binding |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0008270 | molecular_function | zinc ion binding |
| F | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | CYS421 |
| A | CYS424 |
| A | CYS438 |
| A | CYS441 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 502 |
| Chain | Residue |
| A | CYS457 |
| A | CYS463 |
| A | CYS473 |
| A | CYS476 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | CYS424 |
| B | CYS438 |
| B | CYS441 |
| B | CYS421 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 502 |
| Chain | Residue |
| B | CYS457 |
| B | CYS463 |
| B | CYS473 |
| B | CYS476 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 501 |
| Chain | Residue |
| E | CYS421 |
| E | CYS424 |
| E | CYS438 |
| E | CYS441 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 502 |
| Chain | Residue |
| E | CYS457 |
| E | CYS463 |
| E | CYS473 |
| E | CYS476 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 501 |
| Chain | Residue |
| F | CYS421 |
| F | CYS424 |
| F | CYS438 |
| F | CYS441 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 502 |
| Chain | Residue |
| F | CYS457 |
| F | CYS463 |
| F | CYS473 |
| F | CYS476 |
Functional Information from PROSITE/UniProt
| site_id | PS00031 |
| Number of Residues | 27 |
| Details | NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. ClvCg.Deasgc.HYgvltCgsCkvFFkR |
| Chain | Residue | Details |
| A | CYS421-ARG447 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 300 |
| Details | DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | SER418-SER493 | |
| B | SER418-SER493 | |
| E | SER418-SER493 | |
| F | SER418-SER493 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 156 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | CYS421-CYS441 | |
| A | CYS457-CYS476 | |
| B | CYS421-CYS441 | |
| B | CYS457-CYS476 | |
| E | CYS421-CYS441 | |
| E | CYS457-CYS476 | |
| F | CYS421-CYS441 | |
| F | CYS457-CYS476 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:19141540 |
| Chain | Residue | Details |
| A | LYS480 | |
| E | LYS492 | |
| E | LYS494 | |
| E | LYS495 | |
| F | LYS480 | |
| F | LYS492 | |
| F | LYS494 | |
| F | LYS495 | |
| A | LYS492 | |
| A | LYS494 | |
| A | LYS495 | |
| B | LYS480 | |
| B | LYS492 | |
| B | LYS494 | |
| B | LYS495 | |
| E | LYS480 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P06537 |
| Chain | Residue | Details |
| A | LYS419 | |
| B | LYS419 | |
| E | LYS419 | |
| F | LYS419 |
