5CBX

AncGR DNA Binding Domain - (+)GRE Complex

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005815cellular_componentmicrotubule organizing center
A0005759cellular_componentmitochondrial matrix
A0016607cellular_componentnuclear speck
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0032991cellular_componentprotein-containing complex
A0005819cellular_componentspindle
A0001047molecular_functioncore promoter binding
A0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
A0003700molecular_functionDNA-binding transcription factor activity
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0004883molecular_functionglucocorticoid receptor activity
A0051879molecular_functionHsp90 protein binding
A0004879molecular_functionnuclear receptor activity
A0019901molecular_functionprotein kinase binding
A0003723molecular_functionRNA binding
A0000978molecular_functionRNA polymerase II proximal promoter sequence-specific DNA binding
A0005496molecular_functionsteroid binding
A1990239molecular_functionsteroid hormone binding
A0032183molecular_functionSUMO binding
A0008270molecular_functionzinc ion binding
A0006915biological_processapoptotic process
A0007049biological_processcell cycle
A0051301biological_processcell division
A0071549biological_processcellular response to dexamethasone stimulus
A0071385biological_processcellular response to glucocorticoid stimulus
A0071383biological_processcellular response to steroid hormone stimulus
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0006325biological_processchromatin organization
A0007059biological_processchromosome segregation
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0006355biological_processregulation of transcription, DNA-templated
A0007165biological_processsignal transduction
A0006366biological_processtranscription by RNA polymerase II
A0006367biological_processtranscription initiation from RNA polymerase II promoter
A0006351biological_processtranscription, DNA-templated
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005815cellular_componentmicrotubule organizing center
B0005759cellular_componentmitochondrial matrix
B0016607cellular_componentnuclear speck
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0032991cellular_componentprotein-containing complex
B0005819cellular_componentspindle
B0001047molecular_functioncore promoter binding
B0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
B0003700molecular_functionDNA-binding transcription factor activity
B0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
B0004883molecular_functionglucocorticoid receptor activity
B0051879molecular_functionHsp90 protein binding
B0004879molecular_functionnuclear receptor activity
B0019901molecular_functionprotein kinase binding
B0003723molecular_functionRNA binding
B0000978molecular_functionRNA polymerase II proximal promoter sequence-specific DNA binding
B0005496molecular_functionsteroid binding
B1990239molecular_functionsteroid hormone binding
B0032183molecular_functionSUMO binding
B0008270molecular_functionzinc ion binding
B0006915biological_processapoptotic process
B0007049biological_processcell cycle
B0051301biological_processcell division
B0071549biological_processcellular response to dexamethasone stimulus
B0071385biological_processcellular response to glucocorticoid stimulus
B0071383biological_processcellular response to steroid hormone stimulus
B0071560biological_processcellular response to transforming growth factor beta stimulus
B0006325biological_processchromatin organization
B0007059biological_processchromosome segregation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0006355biological_processregulation of transcription, DNA-templated
B0007165biological_processsignal transduction
B0006366biological_processtranscription by RNA polymerase II
B0006367biological_processtranscription initiation from RNA polymerase II promoter
B0006351biological_processtranscription, DNA-templated
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005815cellular_componentmicrotubule organizing center
E0005759cellular_componentmitochondrial matrix
E0016607cellular_componentnuclear speck
E0005654cellular_componentnucleoplasm
E0005634cellular_componentnucleus
E0032991cellular_componentprotein-containing complex
E0005819cellular_componentspindle
E0001047molecular_functioncore promoter binding
E0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
E0003700molecular_functionDNA-binding transcription factor activity
E0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
E0004883molecular_functionglucocorticoid receptor activity
E0051879molecular_functionHsp90 protein binding
E0004879molecular_functionnuclear receptor activity
E0019901molecular_functionprotein kinase binding
E0003723molecular_functionRNA binding
E0000978molecular_functionRNA polymerase II proximal promoter sequence-specific DNA binding
E0005496molecular_functionsteroid binding
E1990239molecular_functionsteroid hormone binding
E0032183molecular_functionSUMO binding
E0008270molecular_functionzinc ion binding
E0006915biological_processapoptotic process
E0007049biological_processcell cycle
E0051301biological_processcell division
E0071549biological_processcellular response to dexamethasone stimulus
E0071385biological_processcellular response to glucocorticoid stimulus
E0071383biological_processcellular response to steroid hormone stimulus
E0071560biological_processcellular response to transforming growth factor beta stimulus
E0006325biological_processchromatin organization
E0007059biological_processchromosome segregation
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0006355biological_processregulation of transcription, DNA-templated
E0007165biological_processsignal transduction
E0006366biological_processtranscription by RNA polymerase II
E0006367biological_processtranscription initiation from RNA polymerase II promoter
E0006351biological_processtranscription, DNA-templated
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005815cellular_componentmicrotubule organizing center
F0005759cellular_componentmitochondrial matrix
F0016607cellular_componentnuclear speck
F0005654cellular_componentnucleoplasm
F0005634cellular_componentnucleus
F0032991cellular_componentprotein-containing complex
F0005819cellular_componentspindle
F0001047molecular_functioncore promoter binding
F0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
F0003700molecular_functionDNA-binding transcription factor activity
F0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
F0004883molecular_functionglucocorticoid receptor activity
F0051879molecular_functionHsp90 protein binding
F0004879molecular_functionnuclear receptor activity
F0019901molecular_functionprotein kinase binding
F0003723molecular_functionRNA binding
F0000978molecular_functionRNA polymerase II proximal promoter sequence-specific DNA binding
F0005496molecular_functionsteroid binding
F1990239molecular_functionsteroid hormone binding
F0032183molecular_functionSUMO binding
F0008270molecular_functionzinc ion binding
F0006915biological_processapoptotic process
F0007049biological_processcell cycle
F0051301biological_processcell division
F0071549biological_processcellular response to dexamethasone stimulus
F0071385biological_processcellular response to glucocorticoid stimulus
F0071383biological_processcellular response to steroid hormone stimulus
F0071560biological_processcellular response to transforming growth factor beta stimulus
F0006325biological_processchromatin organization
F0007059biological_processchromosome segregation
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0006355biological_processregulation of transcription, DNA-templated
F0007165biological_processsignal transduction
F0006366biological_processtranscription by RNA polymerase II
F0006367biological_processtranscription initiation from RNA polymerase II promoter
F0006351biological_processtranscription, DNA-templated
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC14binding site for residue ZN A 501
ChainResidue
ACYS421
ACYS424
ACYS438
ACYS441

AC24binding site for residue ZN A 502
ChainResidue
ACYS457
ACYS463
ACYS473
ACYS476

AC34binding site for residue ZN B 501
ChainResidue
BCYS421
BCYS424
BCYS438
BCYS441

AC44binding site for residue ZN B 502
ChainResidue
BCYS457
BCYS463
BCYS473
BCYS476

AC54binding site for residue ZN E 501
ChainResidue
ECYS421
ECYS424
ECYS438
ECYS441

AC64binding site for residue ZN E 502
ChainResidue
ECYS457
ECYS463
ECYS473
ECYS476

AC74binding site for residue ZN F 501
ChainResidue
FCYS421
FCYS424
FCYS438
FCYS441

AC84binding site for residue ZN F 502
ChainResidue
FCYS457
FCYS463
FCYS473
FCYS476

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails