5C9V

Structure of human Parkin G319A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0016567	biological_process	protein ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS150
A	CYS154
A	CYS212
A	HIS215

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 502

Chain	Residue
A	CYS253
A	HIS257
A	CYS289
A	CYS293

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 503

Chain	Residue
A	CYS449
A	CYS457
A	HIS461
A	CYS446

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 504

Chain	Residue
A	CYS166
A	CYS169
A	CYS196
A	CYS201

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 505

Chain	Residue
A	CYS238
A	CYS241
A	CYS260
A	CYS263

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN A 506

Chain	Residue
A	CYS332
A	CYS337
A	CYS352
A	CYS360

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN A 507

Chain	Residue
A	CYS365
A	CYS368
A	HIS373
A	CYS377

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN A 508

Chain	Residue
A	CYS418
A	CYS421
A	CYS436
A	CYS441

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 A 509

Chain	Residue
A	ARG163
A	LYS211
A	THR217
A	ARG420
A	HOH624

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 A 510

Chain	Residue
A	ASN454
A	ASN454
A	ARG455
A	ARG455

---

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 A 511

Chain	Residue
A	HIS279
A	ARG334
A	GLY361

---

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 A 512

Chain	Residue
A	ASN254
A	PRO294

---

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 A 513

Chain	Residue
A	LYS151
A	HIS302
A	ARG305
A	TYR312
A	HOH603

---

site_id	AD5
Number of Residues	2
Details	binding site for residue SO4 A 514

Chain	Residue
A	ARG348
A	TYR372

---

site_id	AD6
Number of Residues	5
Details	binding site for residue GOL A 515

Chain	Residue
A	CYS368
A	HIS373
A	GLU376
A	CYS377
A	SER378

---

site_id	AD7
Number of Residues	6
Details	binding site for residue GOL A 516

Chain	Residue
A	VAL186
A	LEU187
A	PRO189
A	PHE208
A	HOH604
A	HOH621

---

site_id	AD8
Number of Residues	3
Details	binding site for residue GOL A 517

Chain	Residue
A	ASN295
A	SER296
A	LEU297

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	ZN_FING: RING-type 0; atypical

Chain	Residue	Details
A	SER141-ALA225

---

site_id	SWS_FT_FI2
Number of Residues	55
Details	ZN_FING: RING-type 1 => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS238-CYS293

---

site_id	SWS_FT_FI3
Number of Residues	64
Details	ZN_FING: IBR-type => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	ASN313-CYS377

---

site_id	SWS_FT_FI4
Number of Residues	31
Details	ZN_FING: RING-type 2; atypical => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS418-CYS449

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23770917

Chain	Residue	Details
A	CYS431

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS238
A	CYS449
A	CYS457
A	HIS461
A	CYS241
A	CYS253
A	HIS257
A	CYS260
A	CYS263
A	CYS289
A	CYS293
A	HIS373

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23770917

Chain	Residue	Details
A	CYS332
A	CYS436
A	CYS441
A	CYS446
A	CYS337
A	CYS352
A	CYS360
A	CYS365
A	CYS368
A	CYS377
A	CYS418
A	CYS421

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PINK1 => ECO:0000269|PubMed:18957282

Chain	Residue	Details
A	THR175

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:18957282

Chain	Residue	Details
A	THR217

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:27534820

Chain	Residue	Details
A	LYS349
A	LYS369

---