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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5C8X

ZHD-Intermediate complex after ZHD crystal soaking in ZEN for 20min

Functional Information from GO Data
ChainGOidnamespacecontents
A0009636biological_processresponse to toxic substance
A0016787molecular_functionhydrolase activity
B0009636biological_processresponse to toxic substance
B0016787molecular_functionhydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue ZFR A 301
ChainResidue
AASP31
APRO188
AILE191
APRO192
AHIS242
APHE243
AHOH446
AGLY32
ASER102
ALYS130
ALEU132
ALEU135
AMET154
ATRP183
ATYR187
site_idAC2
Number of Residues8
Detailsbinding site for residue GOL A 302
ChainResidue
ALEU127
APRO128
ATHR129
ALYS130
ASER220
APHE221
AASP223
AHOH515
site_idAC3
Number of Residues3
Detailsbinding site for residue K A 303
ChainResidue
AHIS248
AASP250
AVAL251
site_idAC4
Number of Residues15
Detailsbinding site for residue ZFR B 301
ChainResidue
BASP31
BGLY32
BSER102
BLYS130
BLEU132
BLEU135
BMET154
BTRP183
BTYR187
BPRO188
BILE191
BPRO192
BHIS242
BPHE243
BHOH420
site_idAC5
Number of Residues7
Detailsbinding site for residue GOL B 302
ChainResidue
BLEU127
BPRO128
BTHR129
BLYS130
BSER220
BPHE221
BASP223
site_idAC6
Number of Residues4
Detailsbinding site for residue K B 303
ChainResidue
BHIS248
BPRO249
BASP250
BVAL251
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues360
DetailsDomain: {"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PubMed","id":"28695844","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsActive site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28695844","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2016","firstPage":"7657","lastPage":"7663","volume":"6","journal":"ACS Catal.","title":"Enhanced alpha-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering.","authors":["Xu Z.X.","Liu W.D.","Chen C.C.","Li Q.","Huang J.W.","Ko T.P.","Liu G.","Liu W.","Peng W.","Cheng Y.S.","Chen Y.","Jin J.","Li H.","Zheng Y.Y.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.6b01826"}]}},{"source":"PDB","id":"3WZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5C7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2015","submissionDatabase":"PDB data bank","title":"A case study of lactonase ZHD.","authors":["Ming D.-M.","Qi Q.","Yang W.-J.","Sun K.-L.","Xu T.-Y.","Huang Q.","Hu X.-J.","Lv H."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2019","submissionDatabase":"PDB data bank","title":"Structure of ZHD complex.","authors":["Hu X.J.","Zhou H.J.","Li L."]}},{"source":"PDB","id":"5C7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JRD","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2016","firstPage":"7657","lastPage":"7663","volume":"6","journal":"ACS Catal.","title":"Enhanced alpha-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering.","authors":["Xu Z.X.","Liu W.D.","Chen C.C.","Li Q.","Huang J.W.","Ko T.P.","Liu G.","Liu W.","Peng W.","Cheng Y.S.","Chen Y.","Jin J.","Li H.","Zheng Y.Y.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.6b01826"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2019","submissionDatabase":"PDB data bank","title":"Structure of ZHD complex.","authors":["Hu X.J.","Zhou H.J.","Li L."]}},{"source":"PDB","id":"3WZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JRD","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2015","submissionDatabase":"PDB data bank","title":"A case study of lactonase ZHD.","authors":["Ming D.-M.","Qi Q.","Yang W.-J.","Sun K.-L.","Xu T.-Y.","Huang Q.","Hu X.-J.","Lv H."]}},{"source":"PDB","id":"5C7Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2019","submissionDatabase":"PDB data bank","title":"Structure of ZHD complex.","authors":["Hu X.J.","Zhou H.J.","Li L."]}},{"source":"PDB","id":"6JRD","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2014","firstPage":"62321","lastPage":"62325","volume":"4","journal":"RSC Adv.","title":"Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea.","authors":["Peng W.","Ko T.P.","Yang Y.","Zheng Y.","Chen C.C.","Zhu Z.","Huang C.H.","Zeng Y.F.","Huang J.W.","Wand A.H.-J.","Liu J.R.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/c4ra12111b"}]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2016","firstPage":"7657","lastPage":"7663","volume":"6","journal":"ACS Catal.","title":"Enhanced alpha-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering.","authors":["Xu Z.X.","Liu W.D.","Chen C.C.","Li Q.","Huang J.W.","Ko T.P.","Liu G.","Liu W.","Peng W.","Cheng Y.S.","Chen Y.","Jin J.","Li H.","Zheng Y.Y.","Guo R.T."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.6b01826"}]}},{"source":"PDB","id":"3WZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IE6","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243911

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