5C73

ATP-driven lipid-linked oligosaccharide flippase PglK in outward-occluded conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006869	biological_process	lipid transport
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
B	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0140359	molecular_function	ABC-type transporter activity
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006869	biological_process	lipid transport
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
C	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0140359	molecular_function	ABC-type transporter activity
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0006869	biological_process	lipid transport
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
F	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
F	0046872	molecular_function	metal ion binding
F	0055085	biological_process	transmembrane transport
F	0140359	molecular_function	ABC-type transporter activity
G	0000166	molecular_function	nucleotide binding
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0006869	biological_process	lipid transport
G	0016020	cellular_component	membrane
G	0016887	molecular_function	ATP hydrolysis activity
G	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
G	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
G	0046872	molecular_function	metal ion binding
G	0055085	biological_process	transmembrane transport
G	0140359	molecular_function	ABC-type transporter activity
K	0000166	molecular_function	nucleotide binding
K	0005524	molecular_function	ATP binding
K	0005886	cellular_component	plasma membrane
K	0006869	biological_process	lipid transport
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
K	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
K	0046872	molecular_function	metal ion binding
K	0055085	biological_process	transmembrane transport
K	0140359	molecular_function	ABC-type transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL

Chain	Residue	Details
C	LEU485-LEU499

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	768
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26266984","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1290
Details	Domain: {"description":"ABC transporter","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2214
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"26266984","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	324
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"26266984","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1812
Details	Domain: {"description":"ABC transmembrane type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	126
Details	Region: {"description":"Important for stimulation of ATPase activity by lipid-linked oligosaccharides and subsequent translocation of lipid-linked oligosaccharides","evidences":[{"source":"PubMed","id":"26266984","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---