5C73

ATP-driven lipid-linked oligosaccharide flippase PglK in outward-occluded conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0006869	biological_process	lipid transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity
B	0005524	molecular_function	ATP binding
B	0006869	biological_process	lipid transport
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0140359	molecular_function	ABC-type transporter activity
C	0005524	molecular_function	ATP binding
C	0006869	biological_process	lipid transport
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0140359	molecular_function	ABC-type transporter activity
F	0005524	molecular_function	ATP binding
F	0006869	biological_process	lipid transport
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
F	0046872	molecular_function	metal ion binding
F	0055085	biological_process	transmembrane transport
F	0140359	molecular_function	ABC-type transporter activity
G	0005524	molecular_function	ATP binding
G	0006869	biological_process	lipid transport
G	0016020	cellular_component	membrane
G	0016887	molecular_function	ATP hydrolysis activity
G	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
G	0046872	molecular_function	metal ion binding
G	0055085	biological_process	transmembrane transport
G	0140359	molecular_function	ABC-type transporter activity
K	0005524	molecular_function	ATP binding
K	0006869	biological_process	lipid transport
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
K	0046872	molecular_function	metal ion binding
K	0055085	biological_process	transmembrane transport
K	0140359	molecular_function	ABC-type transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL

Chain	Residue	Details
C	LEU485-LEU499

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2214
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:26266984

Chain	Residue	Details
C	MET1-ASN15
A	ARG99-SER149
A	LYS198-SER254
A	HIS315-LYS564
B	MET1-ASN15
B	ARG99-SER149
B	LYS198-SER254
B	HIS315-LYS564
G	MET1-ASN15
G	ARG99-SER149
G	LYS198-SER254
C	ARG99-SER149
G	HIS315-LYS564
F	MET1-ASN15
F	ARG99-SER149
F	LYS198-SER254
F	HIS315-LYS564
C	LYS198-SER254
C	HIS315-LYS564
K	MET1-ASN15
K	ARG99-SER149
K	LYS198-SER254
K	HIS315-LYS564
A	MET1-ASN15

---

site_id	SWS_FT_FI2
Number of Residues	768
Details	TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000305|PubMed:26266984

Chain	Residue	Details
C	PHE16-VAL38
K	ILE174-ILE197
K	VAL255-VAL276
K	ILE293-TYR314
A	PHE16-VAL38
A	VAL77-ALA98
A	PHE150-ILE170
A	ILE174-ILE197
A	VAL255-VAL276
A	ILE293-TYR314
B	PHE16-VAL38
C	VAL77-ALA98
B	VAL77-ALA98
B	PHE150-ILE170
B	ILE174-ILE197
B	VAL255-VAL276
B	ILE293-TYR314
G	PHE16-VAL38
G	VAL77-ALA98
G	PHE150-ILE170
G	ILE174-ILE197
G	VAL255-VAL276
C	PHE150-ILE170
G	ILE293-TYR314
F	PHE16-VAL38
F	VAL77-ALA98
F	PHE150-ILE170
F	ILE174-ILE197
F	VAL255-VAL276
F	ILE293-TYR314
C	ILE174-ILE197
C	VAL255-VAL276
C	ILE293-TYR314
K	PHE16-VAL38
K	VAL77-ALA98
K	PHE150-ILE170

---

site_id	SWS_FT_FI3
Number of Residues	324
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:26266984

Chain	Residue	Details
C	MET39-GLY76
B	MET39-GLY76
B	ASN171-LYS173
B	PHE277-THR292
G	MET39-GLY76
G	ASN171-LYS173
G	PHE277-THR292
F	MET39-GLY76
F	ASN171-LYS173
F	PHE277-THR292
C	ASN171-LYS173
C	PHE277-THR292
K	MET39-GLY76
K	ASN171-LYS173
K	PHE277-THR292
A	MET39-GLY76
A	ASN171-LYS173
A	PHE277-THR292

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434

Chain	Residue	Details
C	GLY382
K	GLY382
A	GLY382
B	GLY382
G	GLY382
F	GLY382

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