5C65

Structure of the human glucose transporter GLUT3 / SLC2A3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005353	molecular_function	fructose transmembrane transporter activity
A	0005354	molecular_function	galactose transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005536	molecular_function	D-glucose binding
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0015755	biological_process	fructose transmembrane transport
A	0015757	biological_process	galactose transmembrane transport
A	0016020	cellular_component	membrane
A	0016235	cellular_component	aggresome
A	0019852	biological_process	L-ascorbic acid metabolic process
A	0022857	molecular_function	transmembrane transporter activity
A	0030667	cellular_component	secretory granule membrane
A	0033300	molecular_function	dehydroascorbic acid transmembrane transporter activity
A	0035579	cellular_component	specific granule membrane
A	0042995	cellular_component	cell projection
A	0043204	cellular_component	perikaryon
A	0046323	biological_process	D-glucose import
A	0055056	molecular_function	D-glucose transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0070062	cellular_component	extracellular exosome
A	0070821	cellular_component	tertiary granule membrane
A	0070837	biological_process	dehydroascorbic acid transport
A	0098708	biological_process	D-glucose import across plasma membrane
A	0101003	cellular_component	ficolin-1-rich granule membrane
A	0150104	biological_process	transport across blood-brain barrier
A	1904659	biological_process	D-glucose transmembrane transport
B	0005353	molecular_function	fructose transmembrane transporter activity
B	0005354	molecular_function	galactose transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005536	molecular_function	D-glucose binding
B	0005886	cellular_component	plasma membrane
B	0005975	biological_process	carbohydrate metabolic process
B	0015755	biological_process	fructose transmembrane transport
B	0015757	biological_process	galactose transmembrane transport
B	0016020	cellular_component	membrane
B	0016235	cellular_component	aggresome
B	0019852	biological_process	L-ascorbic acid metabolic process
B	0022857	molecular_function	transmembrane transporter activity
B	0030667	cellular_component	secretory granule membrane
B	0033300	molecular_function	dehydroascorbic acid transmembrane transporter activity
B	0035579	cellular_component	specific granule membrane
B	0042995	cellular_component	cell projection
B	0043204	cellular_component	perikaryon
B	0046323	biological_process	D-glucose import
B	0055056	molecular_function	D-glucose transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
B	0070062	cellular_component	extracellular exosome
B	0070821	cellular_component	tertiary granule membrane
B	0070837	biological_process	dehydroascorbic acid transport
B	0098708	biological_process	D-glucose import across plasma membrane
B	0101003	cellular_component	ficolin-1-rich granule membrane
B	0150104	biological_process	transport across blood-brain barrier
B	1904659	biological_process	D-glucose transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue 37X A 501

Chain	Residue
A	ARG91
A	PRO203
A	PHE204
A	37X502
B	37X502

---

site_id	AC2
Number of Residues	8
Details	binding site for residue 37X A 502

Chain	Residue
A	37X501
B	PHE107
B	SER116
B	GLU118
A	PRO8
A	ALA9
A	PHE204
A	ARG228

---

site_id	AC3
Number of Residues	3
Details	binding site for residue 37X A 503

Chain	Residue
A	PHE79
A	SER80
A	37X504

---

site_id	AC4
Number of Residues	3
Details	binding site for residue 37X A 504

Chain	Residue
A	ILE96
A	37X503
B	37X501

---

site_id	AC5
Number of Residues	5
Details	binding site for residue 37X A 505

Chain	Residue
A	ALA114
A	SER116
B	PRO8
B	ALA9
B	37X501

---

site_id	AC6
Number of Residues	3
Details	binding site for residue 37X A 506

Chain	Residue
A	LEU46
A	ALA52
A	ILE121

---

site_id	AC7
Number of Residues	3
Details	binding site for residue Y01 A 507

Chain	Residue
A	ILE274
A	SER408
A	THR411

---

site_id	AC8
Number of Residues	7
Details	binding site for residue 37X B 501

Chain	Residue
A	LEU99
A	LEU100
A	37X504
A	37X505
B	ARG91
B	PRO203
B	PHE204

---

site_id	AC9
Number of Residues	3
Details	binding site for residue 37X B 502

Chain	Residue
A	37X501
B	LEU83
B	37X503

---

site_id	AD1
Number of Residues	2
Details	binding site for residue 37X B 503

Chain	Residue
B	SER80
B	37X502

---

site_id	AD2
Number of Residues	3
Details	binding site for residue Y01 B 504

Chain	Residue
B	PHE79
B	VAL257
B	SER408

---

Functional Information from PROSITE/UniProt

site_id	PS00216
Number of Residues	17
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. SLFLVERAGRRtlhmi.G

Chain	Residue	Details
A	SER322-GLY338

---

site_id	PS00217
Number of Residues	26
Details	SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. ViGLFcGLctgfvpmYigEisptalR

Chain	Residue	Details
A	VAL126-ARG151

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	75
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	120
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Region: {"description":"Important for selectivity against fructose","evidences":[{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26176916","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZW9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P32037","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---