5C65
Structure of the human glucose transporter GLUT3 / SLC2A3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005353 | molecular_function | fructose transmembrane transporter activity |
| A | 0005354 | molecular_function | galactose transmembrane transporter activity |
| A | 0005355 | molecular_function | glucose transmembrane transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005536 | molecular_function | D-glucose binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0015755 | biological_process | fructose transmembrane transport |
| A | 0015757 | biological_process | galactose transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016235 | cellular_component | aggresome |
| A | 0019852 | biological_process | L-ascorbic acid metabolic process |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030667 | cellular_component | secretory granule membrane |
| A | 0033300 | molecular_function | dehydroascorbic acid transmembrane transporter activity |
| A | 0035579 | cellular_component | specific granule membrane |
| A | 0042995 | cellular_component | cell projection |
| A | 0043204 | cellular_component | perikaryon |
| A | 0046323 | biological_process | glucose import |
| A | 0055056 | molecular_function | D-glucose transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070821 | cellular_component | tertiary granule membrane |
| A | 0070837 | biological_process | dehydroascorbic acid transport |
| A | 0098708 | biological_process | glucose import across plasma membrane |
| A | 0101003 | cellular_component | ficolin-1-rich granule membrane |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1904659 | biological_process | glucose transmembrane transport |
| B | 0005353 | molecular_function | fructose transmembrane transporter activity |
| B | 0005354 | molecular_function | galactose transmembrane transporter activity |
| B | 0005355 | molecular_function | glucose transmembrane transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005536 | molecular_function | D-glucose binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0015755 | biological_process | fructose transmembrane transport |
| B | 0015757 | biological_process | galactose transmembrane transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016235 | cellular_component | aggresome |
| B | 0019852 | biological_process | L-ascorbic acid metabolic process |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030667 | cellular_component | secretory granule membrane |
| B | 0033300 | molecular_function | dehydroascorbic acid transmembrane transporter activity |
| B | 0035579 | cellular_component | specific granule membrane |
| B | 0042995 | cellular_component | cell projection |
| B | 0043204 | cellular_component | perikaryon |
| B | 0046323 | biological_process | glucose import |
| B | 0055056 | molecular_function | D-glucose transmembrane transporter activity |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070821 | cellular_component | tertiary granule membrane |
| B | 0070837 | biological_process | dehydroascorbic acid transport |
| B | 0098708 | biological_process | glucose import across plasma membrane |
| B | 0101003 | cellular_component | ficolin-1-rich granule membrane |
| B | 0150104 | biological_process | transport across blood-brain barrier |
| B | 1904659 | biological_process | glucose transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue 37X A 501 |
| Chain | Residue |
| A | ARG91 |
| A | PRO203 |
| A | PHE204 |
| A | 37X502 |
| B | 37X502 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue 37X A 502 |
| Chain | Residue |
| A | 37X501 |
| B | PHE107 |
| B | SER116 |
| B | GLU118 |
| A | PRO8 |
| A | ALA9 |
| A | PHE204 |
| A | ARG228 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue 37X A 503 |
| Chain | Residue |
| A | PHE79 |
| A | SER80 |
| A | 37X504 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue 37X A 504 |
| Chain | Residue |
| A | ILE96 |
| A | 37X503 |
| B | 37X501 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue 37X A 505 |
| Chain | Residue |
| A | ALA114 |
| A | SER116 |
| B | PRO8 |
| B | ALA9 |
| B | 37X501 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue 37X A 506 |
| Chain | Residue |
| A | LEU46 |
| A | ALA52 |
| A | ILE121 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue Y01 A 507 |
| Chain | Residue |
| A | ILE274 |
| A | SER408 |
| A | THR411 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue 37X B 501 |
| Chain | Residue |
| A | LEU99 |
| A | LEU100 |
| A | 37X504 |
| A | 37X505 |
| B | ARG91 |
| B | PRO203 |
| B | PHE204 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue 37X B 502 |
| Chain | Residue |
| A | 37X501 |
| B | LEU83 |
| B | 37X503 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue 37X B 503 |
| Chain | Residue |
| B | SER80 |
| B | 37X502 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue Y01 B 504 |
| Chain | Residue |
| B | PHE79 |
| B | VAL257 |
| B | SER408 |
Functional Information from PROSITE/UniProt
| site_id | PS00216 |
| Number of Residues | 17 |
| Details | SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. SLFLVERAGRRtlhmi.G |
| Chain | Residue | Details |
| A | SER322-GLY338 |
| site_id | PS00217 |
| Number of Residues | 26 |
| Details | SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. ViGLFcGLctgfvpmYigEisptalR |
| Chain | Residue | Details |
| A | VAL126-ARG151 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 202 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-LEU10 | |
| B | CYS205-PRO269 | |
| B | VAL326-ARG331 | |
| B | ALA390-PRO399 | |
| A | ASN86-ARG90 | |
| A | GLY143-ALA153 | |
| A | CYS205-PRO269 | |
| A | VAL326-ARG331 | |
| A | ALA390-PRO399 | |
| B | MET1-LEU10 | |
| B | ASN86-ARG90 | |
| B | GLY143-ALA153 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | ILE11-ASN32 | |
| B | ILE11-ASN32 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 152 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | ALA33-SER64 | |
| B | TYR291-PRO304 | |
| B | LEU353-SER363 | |
| B | PRO421-ALA429 | |
| A | LYS112-GLU118 | |
| A | GLU175-LEU183 | |
| A | TYR291-PRO304 | |
| A | LEU353-SER363 | |
| A | PRO421-ALA429 | |
| B | ALA33-SER64 | |
| B | LYS112-GLU118 | |
| B | GLU175-LEU183 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | LEU65-VAL85 | |
| B | LEU65-VAL85 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | ARG91-CYS111 | |
| B | ARG91-CYS111 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | MET119-ILE142 | |
| B | MET119-ILE142 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | PHE154-LEU174 | |
| B | PHE154-LEU174 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | TRP184-PHE204 | |
| B | TRP184-PHE204 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | ILE270-TYR290 | |
| B | ILE270-TYR290 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | ILE305-LEU325 | |
| B | ILE305-LEU325 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | ARG332-SER352 | |
| B | ARG332-SER352 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | PHE364-VAL389 | |
| B | PHE364-VAL389 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | ALA400-PHE420 | |
| B | ALA400-PHE420 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255, ECO:0000269|PubMed:26176916 |
| Chain | Residue | Details |
| A | TYR430-VAL450 | |
| B | TYR430-VAL450 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26176916, ECO:0007744|PDB:4ZW9 |
| Chain | Residue | Details |
| A | GLN159 | |
| B | ASN315 | |
| B | GLU378 | |
| B | TRP386 | |
| A | GLN280 | |
| A | ASN286 | |
| A | ASN315 | |
| A | GLU378 | |
| A | TRP386 | |
| B | GLN159 | |
| B | GLN280 | |
| B | ASN286 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P32037 |
| Chain | Residue | Details |
| A | THR232 | |
| B | THR232 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN43 | |
| B | GLN43 |
