5C5B

Crystal Structure of Human APPL BAR-PH Heterodimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0042802	molecular_function	identical protein binding
B	0005737	cellular_component	cytoplasm
C	0005737	cellular_component	cytoplasm
C	0042802	molecular_function	identical protein binding
D	0005737	cellular_component	cytoplasm

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue GOL A 401

Chain	Residue
A	ARG154
C	TYR41
C	HIS45

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL B 401

Chain	Residue
A	HIS59
A	LYS63
B	ARG149

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL D 401

Chain	Residue
D	ARG149
C	HIS59
C	LYS63
D	LYS146

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Breakpoint for chromosomal translocation","evidences":[{"source":"PubMed","id":"11431708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	98
Details	Domain: {"description":"PH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00145","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---