5C3R

Crystal structure of the full-length Neurospora crassa T7H in complex with alpha-KG and 5-hydroxymethyluracil (5hmU)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0044283	biological_process	small molecule biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
B	0016491	molecular_function	oxidoreductase activity
B	0044283	biological_process	small molecule biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
C	0016491	molecular_function	oxidoreductase activity
C	0044283	biological_process	small molecule biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
D	0016491	molecular_function	oxidoreductase activity
D	0044283	biological_process	small molecule biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0051213	molecular_function	dioxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NI A 401

Chain	Residue
A	HIS214
A	ASP216
A	HIS271
A	AKG402
A	HOH505

---

site_id	AC2
Number of Residues	15
Details	binding site for residue AKG A 402

Chain	Residue
A	ASP216
A	LEU223
A	HIS271
A	VAL273
A	ARG286
A	SER288
A	PHE292
A	NI401
A	HMU403
A	HOH505
A	HOH622
A	ARG190
A	LEU192
A	TYR194
A	HIS214

---

site_id	AC3
Number of Residues	10
Details	binding site for residue HMU A 403

Chain	Residue
A	ASN87
A	ARG190
A	HIS214
A	ASP216
A	TYR217
A	PHE292
A	AKG402
A	HOH503
A	HOH533
A	HOH544

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 404

Chain	Residue
A	THR42
A	PRO236
A	THR269
A	HOH501
A	HOH523

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 405

Chain	Residue
A	PHE240
A	ASP242
C	GLN279
C	HOH508

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 406

Chain	Residue
A	SER180
A	PHE181
A	HOH521

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 407

Chain	Residue
A	LYS234
A	VAL270
A	HOH513
A	HOH576
B	HOH518
B	HOH565

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO A 408

Chain	Residue
A	ILE53
A	PRO55
A	ARG58
A	ASN248
A	HOH515

---

site_id	AC9
Number of Residues	7
Details	binding site for residue EDO A 409

Chain	Residue
A	GLY10
A	VAL12
A	THR42
A	PRO236
A	HOH564
B	PRO236
B	ASN237

---

site_id	AD1
Number of Residues	5
Details	binding site for residue NI B 401

Chain	Residue
B	HIS214
B	ASP216
B	HIS271
B	AKG402
B	HOH545

---

site_id	AD2
Number of Residues	15
Details	binding site for residue AKG B 402

Chain	Residue
B	ARG190
B	LEU192
B	TYR194
B	HIS214
B	ASP216
B	LEU223
B	HIS271
B	VAL273
B	ARG286
B	SER288
B	PHE292
B	NI401
B	HMU403
B	HOH522
B	HOH545

---

site_id	AD3
Number of Residues	11
Details	binding site for residue HMU B 403

Chain	Residue
B	ASN87
B	ARG190
B	HIS214
B	ASP216
B	TYR217
B	PHE292
B	AKG402
B	HOH514
B	HOH520
B	HOH580
B	HOH613

---

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO B 404

Chain	Residue
B	THR42
B	ALA43
B	PRO236
B	THR269
B	HOH504
B	HOH529

---

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO B 405

Chain	Residue
B	PHE240
B	ASP242
B	GLU8
B	GLN239

---

site_id	AD6
Number of Residues	5
Details	binding site for residue NI C 401

Chain	Residue
C	HIS214
C	ASP216
C	HIS271
C	AKG402
C	HOH503

---

site_id	AD7
Number of Residues	15
Details	binding site for residue AKG C 402

Chain	Residue
C	ARG190
C	LEU192
C	TYR194
C	HIS214
C	ASP216
C	LEU223
C	LEU231
C	HIS271
C	VAL273
C	ARG286
C	SER288
C	PHE292
C	NI401
C	HMU403
C	HOH503

---

site_id	AD8
Number of Residues	11
Details	binding site for residue HMU C 403

Chain	Residue
C	ASN87
C	ARG190
C	HIS214
C	ASP216
C	TYR217
C	PHE292
C	AKG402
C	HOH504
C	HOH506
C	HOH536
C	HOH572

---

site_id	AD9
Number of Residues	7
Details	binding site for residue EDO C 404

Chain	Residue
C	THR42
C	LYS234
C	SER235
C	LYS267
C	THR269
C	HOH541
C	HOH591

---

site_id	AE1
Number of Residues	5
Details	binding site for residue EDO C 405

Chain	Residue
C	ARG260
C	GLU317
C	HOH558
D	ARG260
D	GLU317

---

site_id	AE2
Number of Residues	5
Details	binding site for residue NI D 401

Chain	Residue
D	HIS214
D	ASP216
D	HIS271
D	AKG402
D	HOH537

---

site_id	AE3
Number of Residues	15
Details	binding site for residue AKG D 402

Chain	Residue
D	ARG190
D	LEU192
D	TYR194
D	HIS214
D	ASP216
D	LEU223
D	HIS271
D	VAL273
D	ARG286
D	SER288
D	PHE292
D	NI401
D	HMU403
D	HOH537
D	HOH595

---

site_id	AE4
Number of Residues	8
Details	binding site for residue HMU D 403

Chain	Residue
D	ASN87
D	ARG190
D	HIS214
D	ASP216
D	TYR217
D	PHE292
D	AKG402
D	HOH526

---

site_id	AE5
Number of Residues	6
Details	binding site for residue EDO D 404

Chain	Residue
D	THR42
D	LYS234
D	SER235
D	THR269
D	HOH560
D	HOH565

---

site_id	AE6
Number of Residues	6
Details	binding site for residue EDO D 405

Chain	Residue
D	SER19
D	LEU22
D	GLU23
D	ASN50
D	ILE51
D	PRO52

---

site_id	AE7
Number of Residues	4
Details	binding site for residue EDO D 406

Chain	Residue
A	VAL282
D	PHE240
D	ILE241
D	ASP242

---