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5C2J

Complex structure of the GAP domain of MgcRacGAP and Cdc42

Functional Information from GO Data
ChainGOidnamespacecontents
A0007165biological_processsignal transduction
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000322cellular_componentstorage vacuole
B0002040biological_processsprouting angiogenesis
B0003015biological_processheart process
B0003161biological_processcardiac conduction system development
B0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0006468biological_processprotein phosphorylation
B0006897biological_processendocytosis
B0006911biological_processphagocytosis, engulfment
B0007015biological_processactin filament organization
B0007030biological_processGolgi organization
B0007088biological_processregulation of mitotic nuclear division
B0007097biological_processnuclear migration
B0007163biological_processestablishment or maintenance of cell polarity
B0007165biological_processsignal transduction
B0007229biological_processintegrin-mediated signaling pathway
B0007264biological_processsmall GTPase-mediated signal transduction
B0007266biological_processRho protein signal transduction
B0007399biological_processnervous system development
B0008104biological_processintracellular protein localization
B0009653biological_processanatomical structure morphogenesis
B0010591biological_processregulation of lamellipodium assembly
B0010592biological_processpositive regulation of lamellipodium assembly
B0015630cellular_componentmicrotubule cytoskeleton
B0016020cellular_componentmembrane
B0016197biological_processendosomal transport
B0016787molecular_functionhydrolase activity
B0017119cellular_componentGolgi transport complex
B0019901molecular_functionprotein kinase binding
B0030010biological_processestablishment of cell polarity
B0030036biological_processactin cytoskeleton organization
B0030141cellular_componentsecretory granule
B0030154biological_processcell differentiation
B0030175cellular_componentfilopodium
B0030307biological_processpositive regulation of cell growth
B0030335biological_processpositive regulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030742molecular_functionGTP-dependent protein binding
B0031252cellular_componentcell leading edge
B0031256cellular_componentleading edge membrane
B0031258cellular_componentlamellipodium membrane
B0031274biological_processpositive regulation of pseudopodium assembly
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
B0031996molecular_functionthioesterase binding
B0032427molecular_functionGBD domain binding
B0032467biological_processpositive regulation of cytokinesis
B0032956biological_processregulation of actin cytoskeleton organization
B0032991cellular_componentprotein-containing complex
B0034191molecular_functionapolipoprotein A-I receptor binding
B0034329biological_processcell junction assembly
B0034332biological_processadherens junction organization
B0035050biological_processembryonic heart tube development
B0035088biological_processestablishment or maintenance of apical/basal cell polarity
B0036336biological_processdendritic cell migration
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0038189biological_processneuropilin signaling pathway
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043085biological_processpositive regulation of catalytic activity
B0043209cellular_componentmyelin sheath
B0043410biological_processpositive regulation of MAPK cascade
B0043525biological_processpositive regulation of neuron apoptotic process
B0044788biological_processhost-mediated perturbation of viral process
B0045177cellular_componentapical part of cell
B0045198biological_processestablishment of epithelial cell apical/basal polarity
B0045335cellular_componentphagocytic vesicle
B0045740biological_processpositive regulation of DNA replication
B0046330biological_processpositive regulation of JNK cascade
B0046847biological_processfilopodium assembly
B0048549biological_processpositive regulation of pinocytosis
B0048664biological_processneuron fate determination
B0051130biological_processpositive regulation of cellular component organization
B0051233cellular_componentspindle midzone
B0051489biological_processregulation of filopodium assembly
B0051491biological_processpositive regulation of filopodium assembly
B0051492biological_processregulation of stress fiber assembly
B0051496biological_processpositive regulation of stress fiber assembly
B0051647biological_processnucleus localization
B0051683biological_processestablishment of Golgi localization
B0051835biological_processpositive regulation of synapse structural plasticity
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051988biological_processregulation of attachment of spindle microtubules to kinetochore
B0060047biological_processheart contraction
B0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
B0060997biological_processdendritic spine morphogenesis
B0061630molecular_functionubiquitin protein ligase activity
B0071346biological_processcellular response to type II interferon
B0071944cellular_componentcell periphery
B0072384biological_processorganelle transport along microtubule
B0072686cellular_componentmitotic spindle
B0086100biological_processendothelin receptor signaling pathway
B0090135biological_processactin filament branching
B0090316biological_processpositive regulation of intracellular protein transport
B0098609biological_processcell-cell adhesion
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0099175biological_processregulation of postsynapse organization
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue MG B 500
ChainResidue
BTHR17
BTHR35
BGDP501
BAF3502
BHOH602
BHOH618

site_idAC2
Number of Residues22
Detailsbinding site for residue GDP B 501
ChainResidue
BGLY15
BLYS16
BTHR17
BCYS18
BPHE28
BTYR32
BGLN116
BASP118
BLEU119
BSER158
BALA159
BLEU160
BMG500
BAF3502
BHOH602
BHOH607
BHOH608
BHOH618
BHOH631
AARG385
BALA13
BVAL14

site_idAC3
Number of Residues12
Detailsbinding site for residue AF3 B 502
ChainResidue
AARG385
BGLY12
BALA13
BLYS16
BTHR35
BGLY60
BGLN61
BMG500
BGDP501
BHOH602
BHOH613
BHOH618

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues190
DetailsDomain: {"description":"Rho-GAP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00172","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state","evidences":[{"source":"PROSITE-ProRule","id":"PRU00172","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by AURKB","evidences":[{"source":"PubMed","id":"12689593","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsPropeptide: {"description":"Removed in mature form","featureId":"PRO_0000030428","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues8
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues14
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"UniProtKB","id":"P60953","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Cysteine methyl ester","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues1
DetailsLipidation: {"description":"S-geranylgeranyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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