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5C24

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-6,8-dimethylindolizine-2-carbonitrile (JLJ605), a non-nucleoside inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003964molecular_functionRNA-directed DNA polymerase activity
A0004523molecular_functionRNA-DNA hybrid ribonuclease activity
A0006278biological_processRNA-templated DNA biosynthetic process
B0003964molecular_functionRNA-directed DNA polymerase activity
B0006278biological_processRNA-templated DNA biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue 4XO A 601
ChainResidue
ALEU100
ALEU234
AHIS235
ATYR318
BGLU138
ALYS101
ALYS103
AVAL179
ATYR181
ATYR188
AGLY190
APHE227
ATRP229

site_idAC2
Number of Residues2
Detailsbinding site for residue MG A 602
ChainResidue
ALYS73
AGLN151

site_idAC3
Number of Residues4
Detailsbinding site for residue SO4 A 603
ChainResidue
ALYS331
AGLY333
AGLN334
ALYS512

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsRegion: {"description":"RT 'primer grip'"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues32
DetailsMotif: {"description":"Tryptophan repeat motif"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues3
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsSite: {"description":"Essential for RT p66/p51 heterodimerization"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsSite: {"description":"Cleavage; by viral protease; partial"}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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