5C1D

Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RB2L)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006493	biological_process	protein O-linked glycosylation
A	0016757	molecular_function	glycosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue 12V A 1101

Chain	Residue
A	HIS498
A	LYS842
A	LEU866
A	VAL895
A	ALA896
A	LYS898
A	HIS901
A	ARG904
A	HIS920
A	THR921
A	THR922
A	PRO559
A	ASP925
A	HOH1267
A	HOH1283
A	HOH1284
A	HOH1325
A	HOH1336
C	PRO3
C	VAL4
C	SER5
A	THR560
A	LEU653
A	GLY654
A	PRO656
A	PHE694
A	GLN839
A	TYR841

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site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 A 1102

Chain	Residue
A	LEU405
A	HIS429
A	HIS429
A	SER432
A	ASN434

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site_id	AC3
Number of Residues	6
Details	binding site for residue PO4 A 1103

Chain	Residue
A	GLN413
A	PRO436
A	ILE439
A	VAL871
A	ASN875
A	HOH1358

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q64700

Chain	Residue	Details
C	THR2

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:26237509

Chain	Residue	Details
C	SER5
A	ALA852
A	GLN906
A	CYS911
A	GLY930
A	THR935

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260

Chain	Residue	Details
A	ASP454

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P56558

Chain	Residue	Details
A	LYS989

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473

Chain	Residue	Details
A	GLN399

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