5C0E
HLA-A02 carrying YLGGPDFPTI
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0001913 | biological_process | T cell mediated cytotoxicity |
| B | 0001916 | biological_process | positive regulation of T cell mediated cytotoxicity |
| B | 0002237 | biological_process | response to molecule of bacterial origin |
| B | 0002376 | biological_process | immune system process |
| B | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| B | 0002481 | biological_process | antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent |
| B | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| B | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| B | 0002726 | biological_process | positive regulation of T cell cytokine production |
| B | 0005198 | molecular_function | structural molecule activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005925 | cellular_component | focal adhesion |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0006955 | biological_process | immune response |
| B | 0007608 | biological_process | sensory perception of smell |
| B | 0007611 | biological_process | learning or memory |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0009986 | cellular_component | cell surface |
| B | 0010977 | biological_process | negative regulation of neuron projection development |
| B | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| B | 0023026 | molecular_function | MHC class II protein complex binding |
| B | 0030670 | cellular_component | phagocytic vesicle membrane |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0031905 | cellular_component | early endosome lumen |
| B | 0032092 | biological_process | positive regulation of protein binding |
| B | 0033077 | biological_process | T cell differentiation in thymus |
| B | 0034756 | biological_process | regulation of iron ion transport |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0042026 | biological_process | protein refolding |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0042612 | cellular_component | MHC class I protein complex |
| B | 0042613 | cellular_component | MHC class II protein complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0042824 | cellular_component | MHC class I peptide loading complex |
| B | 0045646 | biological_process | regulation of erythrocyte differentiation |
| B | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| B | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| B | 0050768 | biological_process | negative regulation of neurogenesis |
| B | 0050778 | biological_process | positive regulation of immune response |
| B | 0050870 | biological_process | positive regulation of T cell activation |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071281 | biological_process | cellular response to iron ion |
| B | 0071283 | biological_process | cellular response to iron(III) ion |
| B | 0071316 | biological_process | cellular response to nicotine |
| B | 1900121 | biological_process | negative regulation of receptor binding |
| B | 1900122 | biological_process | positive regulation of receptor binding |
| B | 1904434 | biological_process | positive regulation of ferrous iron binding |
| B | 1904437 | biological_process | positive regulation of transferrin receptor binding |
| B | 1904724 | cellular_component | tertiary granule lumen |
| B | 1990000 | biological_process | amyloid fibril formation |
| B | 1990712 | cellular_component | HFE-transferrin receptor complex |
| B | 2000774 | biological_process | positive regulation of cellular senescence |
| B | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue BR A 301 |
| Chain | Residue |
| A | GLY16 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | PRO235 |
| A | PG4319 |
| B | SER52 |
| B | TYR63 |
| B | HOH226 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | GLN72 |
| A | ARG75 |
| A | HOH492 |
| A | GLU19 |
| A | PRO20 |
| A | SER71 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | GLU212 |
| A | ILE213 |
| A | THR214 |
| A | GLN262 |
| A | HIS263 |
| A | GLU264 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 305 |
| Chain | Residue |
| A | GLU222 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 306 |
| Chain | Residue |
| A | ARG6 |
| A | PHE8 |
| A | TYR27 |
| A | ASP29 |
| A | HOH472 |
| B | HOH207 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 307 |
| Chain | Residue |
| A | GLU166 |
| A | TRP167 |
| A | ARG170 |
| A | HOH554 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 308 |
| Chain | Residue |
| A | TYR84 |
| A | THR142 |
| A | PG4320 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 309 |
| Chain | Residue |
| A | GLY237 |
| A | HOH443 |
| B | SER52 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 310 |
| Chain | Residue |
| A | LYS121 |
| A | PG4320 |
| A | HOH403 |
| A | HOH480 |
| A | HOH568 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 311 |
| Chain | Residue |
| A | GLU53 |
| A | TRP60 |
| A | PG4322 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 312 |
| Chain | Residue |
| A | ARG65 |
| A | PG4318 |
| C | GLY4 |
| C | PRO5 |
| C | GOL101 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 313 |
| Chain | Residue |
| A | ALA49 |
| A | PRO50 |
| A | GLU53 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 314 |
| Chain | Residue |
| A | GLN115 |
| A | ASP122 |
| B | LYS58 |
| B | ASP59 |
| B | PG4106 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 315 |
| Chain | Residue |
| A | ARG14 |
| A | GLY18 |
| A | GLU19 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 316 |
| Chain | Residue |
| A | GLN141 |
| A | LYS144 |
| A | HOH424 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 317 |
| Chain | Residue |
| A | GLY237 |
| A | ASP238 |
| A | GLY239 |
| A | HOH449 |
| A | HOH514 |
| site_id | AD9 |
| Number of Residues | 12 |
| Details | binding site for residue PG4 A 318 |
| Chain | Residue |
| A | GLY56 |
| A | PRO57 |
| A | GLU58 |
| A | TYR59 |
| A | ARG65 |
| A | LYS66 |
| A | EDO312 |
| A | HOH409 |
| A | HOH419 |
| A | HOH646 |
| C | TYR1 |
| C | HOH207 |
| site_id | AE1 |
| Number of Residues | 14 |
| Details | binding site for residue PG4 A 319 |
| Chain | Residue |
| A | TYR27 |
| A | ASP30 |
| A | THR31 |
| A | GLN32 |
| A | THR233 |
| A | PHE241 |
| A | EDO302 |
| A | HOH410 |
| A | HOH414 |
| A | HOH439 |
| A | HOH474 |
| A | HOH484 |
| A | HOH547 |
| B | TYR63 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue PG4 A 320 |
| Chain | Residue |
| A | TYR85 |
| A | ASP137 |
| A | MET138 |
| A | EDO308 |
| A | EDO310 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue PG4 A 321 |
| Chain | Residue |
| A | MET189 |
| A | ARG273 |
| A | HOH493 |
| A | HOH528 |
| B | PG4105 |
| B | PG4109 |
| A | HIS188 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue PG4 A 322 |
| Chain | Residue |
| A | SER42 |
| A | ARG44 |
| A | MET45 |
| A | PRO47 |
| A | PRO57 |
| A | TRP60 |
| A | EDO311 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 101 |
| Chain | Residue |
| B | GLU36 |
| B | ASP38 |
| B | ARG81 |
| B | PRO90 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 102 |
| Chain | Residue |
| B | ASP34 |
| B | GLU36 |
| B | ASN83 |
| B | HIS84 |
| B | HOH240 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 103 |
| Chain | Residue |
| B | ASN42 |
| B | GLY43 |
| B | GLU77 |
| B | ALA79 |
| B | LYS94 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 104 |
| Chain | Residue |
| B | ASN17 |
| B | THR73 |
| B | GLU74 |
| B | HOH205 |
| site_id | AE9 |
| Number of Residues | 13 |
| Details | binding site for residue PG4 B 105 |
| Chain | Residue |
| A | LYS186 |
| A | HIS188 |
| A | LEU206 |
| A | SER207 |
| A | GLN242 |
| A | PG4321 |
| A | HOH616 |
| B | ARG12 |
| B | HIS13 |
| B | PRO14 |
| B | PG4108 |
| B | PG4109 |
| B | HOH235 |
| site_id | AF1 |
| Number of Residues | 9 |
| Details | binding site for residue PG4 B 106 |
| Chain | Residue |
| A | PHE8 |
| A | TYR113 |
| A | GLN115 |
| A | EDO314 |
| B | PHE56 |
| B | SER57 |
| B | LYS58 |
| B | TRP60 |
| B | HOH202 |
| site_id | AF2 |
| Number of Residues | 14 |
| Details | binding site for residue PG4 B 107 |
| Chain | Residue |
| A | ILE23 |
| A | ARG35 |
| A | ASP37 |
| A | HOH530 |
| B | SER33 |
| B | ASP34 |
| B | ILE35 |
| B | HIS51 |
| B | SER52 |
| B | ASP53 |
| B | LEU54 |
| B | LEU64 |
| B | TYR66 |
| B | HOH280 |
| site_id | AF3 |
| Number of Residues | 16 |
| Details | binding site for residue PG4 B 108 |
| Chain | Residue |
| A | HIS188 |
| A | THR190 |
| A | TRP204 |
| A | LEU206 |
| A | ARG234 |
| A | GLN242 |
| B | TYR10 |
| B | SER11 |
| B | HIS13 |
| B | PRO14 |
| B | TRP95 |
| B | ARG97 |
| B | MET99 |
| B | PG4105 |
| B | PG4110 |
| B | HOH249 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue PG4 B 109 |
| Chain | Residue |
| A | LYS186 |
| A | PG4321 |
| B | PRO14 |
| B | GLU16 |
| B | PG4105 |
| B | HOH276 |
| site_id | AF5 |
| Number of Residues | 12 |
| Details | binding site for residue PG4 B 110 |
| Chain | Residue |
| A | GLU229 |
| A | VAL231 |
| A | ARG234 |
| B | GLN8 |
| B | VAL9 |
| B | TYR10 |
| B | LYS94 |
| B | TRP95 |
| B | ASP96 |
| B | MET99 |
| B | PG4108 |
| B | HOH216 |
| site_id | AF6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 101 |
| Chain | Residue |
| A | TYR159 |
| A | THR163 |
| A | EDO312 |
| C | TYR1 |
| C | GLN2 |
| C | PHE3 |
| C | GLY4 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH |
| Chain | Residue | Details |
| B | TYR78-HIS84 | |
| A | TYR257-HIS263 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 |
| Chain | Residue | Details |
| B | GLN2 | |
| A | THR73 | |
| A | TYR84 | |
| A | THR143 | |
| A | LYS146 | |
| A | TYR171 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443 |
| Chain | Residue | Details |
| A | TYR159 | |
| B | ILE1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 |
| Chain | Residue | Details |
| B | LYS19 | |
| B | LYS41 | |
| B | LYS48 | |
| B | LYS58 | |
| B | LYS91 | |
| B | LYS94 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN86 |
