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5C0B

1E6 TCR in complex with HLA-A02 carrying RQFGPDFPTI

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0032092biological_processpositive regulation of protein binding
B0033077biological_processT cell differentiation in thymus
B0034756biological_processregulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1900121biological_processnegative regulation of receptor binding
B1900122biological_processpositive regulation of receptor binding
B1904434biological_processpositive regulation of ferrous iron binding
B1904437biological_processpositive regulation of transferrin receptor binding
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
D0002250biological_processadaptive immune response
D0002376biological_processimmune system process
D0005886cellular_componentplasma membrane
D0016020cellular_componentmembrane
D0042101cellular_componentT cell receptor complex
D0042605molecular_functionpeptide antigen binding
G0000139cellular_componentGolgi membrane
G0001913biological_processT cell mediated cytotoxicity
G0001916biological_processpositive regulation of T cell mediated cytotoxicity
G0002237biological_processresponse to molecule of bacterial origin
G0002376biological_processimmune system process
G0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
G0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
G0002502biological_processpeptide antigen assembly with MHC class I protein complex
G0002503biological_processpeptide antigen assembly with MHC class II protein complex
G0002726biological_processpositive regulation of T cell cytokine production
G0005198molecular_functionstructural molecule activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005765cellular_componentlysosomal membrane
G0005783cellular_componentendoplasmic reticulum
G0005788cellular_componentendoplasmic reticulum lumen
G0005794cellular_componentGolgi apparatus
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0005925cellular_componentfocal adhesion
G0006826biological_processiron ion transport
G0006879biological_processintracellular iron ion homeostasis
G0006955biological_processimmune response
G0007608biological_processsensory perception of smell
G0007611biological_processlearning or memory
G0009897cellular_componentexternal side of plasma membrane
G0009986cellular_componentcell surface
G0010977biological_processnegative regulation of neuron projection development
G0012507cellular_componentER to Golgi transport vesicle membrane
G0016020cellular_componentmembrane
G0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
G0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
G0023026molecular_functionMHC class II protein complex binding
G0030670cellular_componentphagocytic vesicle membrane
G0031901cellular_componentearly endosome membrane
G0031902cellular_componentlate endosome membrane
G0031905cellular_componentearly endosome lumen
G0032092biological_processpositive regulation of protein binding
G0033077biological_processT cell differentiation in thymus
G0034756biological_processregulation of iron ion transport
G0035580cellular_componentspecific granule lumen
G0042026biological_processprotein refolding
G0042605molecular_functionpeptide antigen binding
G0042612cellular_componentMHC class I protein complex
G0042613cellular_componentMHC class II protein complex
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0042824cellular_componentMHC class I peptide loading complex
G0045646biological_processregulation of erythrocyte differentiation
G0048260biological_processpositive regulation of receptor-mediated endocytosis
G0050680biological_processnegative regulation of epithelial cell proliferation
G0050768biological_processnegative regulation of neurogenesis
G0050778biological_processpositive regulation of immune response
G0050870biological_processpositive regulation of T cell activation
G0051289biological_processprotein homotetramerization
G0055038cellular_componentrecycling endosome membrane
G0060586biological_processmulticellular organismal-level iron ion homeostasis
G0070062cellular_componentextracellular exosome
G0071281biological_processcellular response to iron ion
G0071283biological_processcellular response to iron(III) ion
G0071316biological_processcellular response to nicotine
G1900121biological_processnegative regulation of receptor binding
G1900122biological_processpositive regulation of receptor binding
G1904434biological_processpositive regulation of ferrous iron binding
G1904437biological_processpositive regulation of transferrin receptor binding
G1904724cellular_componenttertiary granule lumen
G1990000biological_processamyloid fibril formation
G1990712cellular_componentHFE-transferrin receptor complex
G2000774biological_processpositive regulation of cellular senescence
G2000978biological_processnegative regulation of forebrain neuron differentiation
I0002250biological_processadaptive immune response
I0002376biological_processimmune system process
I0005886cellular_componentplasma membrane
I0016020cellular_componentmembrane
I0042101cellular_componentT cell receptor complex
I0042605molecular_functionpeptide antigen binding
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue EDO A 301
ChainResidue
APHE36
AASP37
AALA40
ASER42
AGLN43
AARG44
AHOH409

site_idAC2
Number of Residues3
Detailsbinding site for residue EDO A 302
ChainResidue
AASP102
ASER2
AARG6

site_idAC3
Number of Residues6
Detailsbinding site for residue EDO A 303
ChainResidue
AGLU19
APRO20
APHE22
ASER71
AGLN72
AHOH413

site_idAC4
Number of Residues5
Detailsbinding site for residue EDO A 304
ChainResidue
AARG14
AARG17
AGLY18
AGLU19
JARG22

site_idAC5
Number of Residues5
Detailsbinding site for residue EDO A 305
ChainResidue
AASP61
ATHR64
ALYS68
EEDO303
EHOH420

site_idAC6
Number of Residues6
Detailsbinding site for residue EDO A 307
ChainResidue
AALA158
ATYR159
ATHR163
DGLN31
DTYR51
DASP94

site_idAC7
Number of Residues3
Detailsbinding site for residue EDO A 308
ChainResidue
AASP196
AHIS197
FGLU229

site_idAC8
Number of Residues2
Detailsbinding site for residue EDO A 309
ChainResidue
AGLN141
AGLU148

site_idAC9
Number of Residues4
Detailsbinding site for residue GOL A 310
ChainResidue
AGLN87
AHIS93
BMET0
JGLY16

site_idAD1
Number of Residues6
Detailsbinding site for residue SO4 A 311
ChainResidue
AALA90
AHOH451
JGLY3
JPRO25
JILE26
JSER27

site_idAD2
Number of Residues4
Detailsbinding site for residue SO4 A 312
ChainResidue
AGLU89
JLYS24
JSER73
JHOH407

site_idAD3
Number of Residues8
Detailsbinding site for residue EDO B 301
ChainResidue
AARG234
AGLN242
BTYR10
BSER11
BHIS13
BPRO14
BHOH417
BHOH420

site_idAD4
Number of Residues4
Detailsbinding site for residue EDO B 302
ChainResidue
AARG14
BASP34
BGOL306
BHOH414

site_idAD5
Number of Residues7
Detailsbinding site for residue EDO B 303
ChainResidue
BGLN8
BVAL9
BVAL93
BLYS94
BMET99
BHOH403
BHOH432

site_idAD6
Number of Residues6
Detailsbinding site for residue EDO B 304
ChainResidue
BARG45
BGLU47
BLYS48
BHOH404
JGLU221
JLYS231

site_idAD7
Number of Residues3
Detailsbinding site for residue EDO B 305
ChainResidue
JPRO124
JGLN235
JHOH417

site_idAD8
Number of Residues7
Detailsbinding site for residue GOL B 306
ChainResidue
AILE23
BSER33
BASP34
BLEU54
BEDO302
BHOH411
BHOH413

site_idAD9
Number of Residues7
Detailsbinding site for residue SO4 B 307
ChainResidue
AGLN226
BASN17
BGLY18
BTHR73
BGLU74
BHOH431
BHOH433

site_idAE1
Number of Residues3
Detailsbinding site for residue EDO D 301
ChainResidue
DSER12
DHOH401
ITYR71

site_idAE2
Number of Residues3
Detailsbinding site for residue EDO D 302
ChainResidue
DARG77
IARG77
IEDO306

site_idAE3
Number of Residues9
Detailsbinding site for residue EDO D 303
ChainResidue
DPRO14
DALA17
DHOH401
DHOH424
DHOH433
IASN55
IGLN64
IVAL65
IASP66

site_idAE4
Number of Residues5
Detailsbinding site for residue EDO D 304
ChainResidue
DARG41
DLYS42
EPHE91
EARG112
EEDO307

site_idAE5
Number of Residues5
Detailsbinding site for residue EDO D 305
ChainResidue
AGLN155
DTYR32
DARG92
DHOH405
EALA101

site_idAE6
Number of Residues7
Detailsbinding site for residue EDO D 306
ChainResidue
DGLN64
DTYR71
DHOH428
IVAL13
IILE18
IVAL19
ISER20

site_idAE7
Number of Residues5
Detailsbinding site for residue EDO E 301
ChainResidue
DARG92
DTYR97
DLEU99
ELEU100
EASN103

site_idAE8
Number of Residues6
Detailsbinding site for residue EDO E 302
ChainResidue
ELEU116
EGLU117
EASP118
EASN121
ETYR153
EASP187

site_idAE9
Number of Residues6
Detailsbinding site for residue EDO E 303
ChainResidue
ALYS68
AEDO305
EPRO54
EILE55
EASP56
EASP57

site_idAF1
Number of Residues4
Detailsbinding site for residue EDO E 304
ChainResidue
EGLY3
EVAL4
EILE26
EPHE107

site_idAF2
Number of Residues3
Detailsbinding site for residue EDO E 305
ChainResidue
EVAL168
EHIS169
ESER170

site_idAF3
Number of Residues2
Detailsbinding site for residue EDO E 306
ChainResidue
EARG85
ELYS102

site_idAF4
Number of Residues5
Detailsbinding site for residue EDO E 307
ChainResidue
DEDO304
EGLN37
EMET39
EVAL89
EHOH467

site_idAF5
Number of Residues6
Detailsbinding site for residue EDO E 308
ChainResidue
EALA88
EARG112
ELEU113
ESER114
EASP155
EHIS156

site_idAF6
Number of Residues3
Detailsbinding site for residue EDO E 309
ChainResidue
EARG9
EGLN215
ETYR217

site_idAF7
Number of Residues6
Detailsbinding site for residue EDO E 310
ChainResidue
ALYS146
EASP30
ETYR31
ELEU96
ETRP97
EGLU98

site_idAF8
Number of Residues8
Detailsbinding site for residue GOL E 311
ChainResidue
DLEU88
DGLY102
DSER103
EGLN37
ETHR38
EMET39
EGLY42
ELEU43

site_idAF9
Number of Residues6
Detailsbinding site for residue SO4 E 312
ChainResidue
AALA150
AHIS151
DTYR49
EALA101
ELYS102
EHOH446

site_idAG1
Number of Residues4
Detailsbinding site for residue SO4 E 313
ChainResidue
EARG22
EHOH409
FARG17
FGLY18

site_idAG2
Number of Residues7
Detailsbinding site for residue EDO F 301
ChainResidue
FTYR85
FTYR118
FLYS121
FASP122
FALA136
FASP137
FEDO305

site_idAG3
Number of Residues6
Detailsbinding site for residue EDO F 302
ChainResidue
FGLU19
FPRO20
FSER71
FGLN72
FARG75
FHOH405

site_idAG4
Number of Residues4
Detailsbinding site for residue EDO F 303
ChainResidue
FARG44
FMET45
FTRP60
FGLN141

site_idAG5
Number of Residues6
Detailsbinding site for residue EDO F 304
ChainResidue
FVAL12
FARG14
FARG21
FHOH426
GASP34
GEDO102

site_idAG6
Number of Residues6
Detailsbinding site for residue EDO F 305
ChainResidue
FTYR85
FGLN87
FTYR118
FASP119
FLYS121
FEDO301

site_idAG7
Number of Residues7
Detailsbinding site for residue EDO F 306
ChainResidue
FPHE36
FASP37
FALA40
FSER42
FGLN43
FARG44
FGLU46

site_idAG8
Number of Residues6
Detailsbinding site for residue EDO F 307
ChainResidue
FGLU53
FGLN54
FLYS127
FSER132
FTRP133
FHOH404

site_idAG9
Number of Residues4
Detailsbinding site for residue GOL F 308
ChainResidue
FSER4
FARG6
FPHE8
FASP29

site_idAH1
Number of Residues5
Detailsbinding site for residue SO4 F 309
ChainResidue
FSER13
FARG75
FLEU78
FHOH408
FHOH460

site_idAH2
Number of Residues3
Detailsbinding site for residue SO4 F 310
ChainResidue
FARG21
FHOH409
GHIS51

site_idAH3
Number of Residues4
Detailsbinding site for residue SO4 F 311
ChainResidue
FTYR84
FALA139
FTHR142
FHOH482

site_idAH4
Number of Residues7
Detailsbinding site for residue EDO G 101
ChainResidue
FARG234
FGLN242
GTYR10
GSER11
GHIS13
GPRO14
GHOH211

site_idAH5
Number of Residues6
Detailsbinding site for residue EDO G 102
ChainResidue
FARG21
FEDO304
FHOH409
GSER33
GASP34
GHOH201

site_idAH6
Number of Residues3
Detailsbinding site for residue EDO G 103
ChainResidue
FASP238
GARG12
GHIS13

site_idAH7
Number of Residues2
Detailsbinding site for residue EDO G 104
ChainResidue
GVAL37
GASP38

site_idAH8
Number of Residues8
Detailsbinding site for residue EDO H 101
ChainResidue
FLYS146
HPRO8
HTHR9
HHOH205
JASP30
JLEU96
JTRP97
JGLU98

site_idAH9
Number of Residues4
Detailsbinding site for residue EDO I 301
ChainResidue
IARG92
ITYR97
ILEU99
JASN103

site_idAI1
Number of Residues3
Detailsbinding site for residue EDO I 302
ChainResidue
IGLY59
IARG60
IARG77

site_idAI2
Number of Residues5
Detailsbinding site for residue EDO I 303
ChainResidue
IASP112
IILE113
IASP140
ISER141
IGLN142

site_idAI3
Number of Residues3
Detailsbinding site for residue EDO I 304
ChainResidue
ILYS179
ISER180
IHOH432

site_idAI4
Number of Residues1
Detailsbinding site for residue EDO I 305
ChainResidue
IARG60

site_idAI5
Number of Residues5
Detailsbinding site for residue EDO I 306
ChainResidue
DEDO302
IGLY16
IILE18
IARG77
IASP78

site_idAI6
Number of Residues4
Detailsbinding site for residue EDO I 307
ChainResidue
FHOH442
FHOH459
ISER95
IHOH415

site_idAI7
Number of Residues5
Detailsbinding site for residue GOL I 308
ChainResidue
DASP66
DSER69
DTYR71
ISER12
IVAL13

site_idAI8
Number of Residues6
Detailsbinding site for residue EDO J 301
ChainResidue
FGLN255
FARG273
FTRP274
FGLU275
JGLU240
JTRP242

site_idAI9
Number of Residues4
Detailsbinding site for residue EDO J 302
ChainResidue
AARG17
JPRO8
JARG9
JHOH454

site_idAJ1
Number of Residues1
Detailsbinding site for residue EDO J 303
ChainResidue
JLEU185

site_idAJ2
Number of Residues6
Detailsbinding site for residue EDO J 304
ChainResidue
JLEU116
JGLU117
JASP118
JASN121
JTYR153
JASP187

site_idAJ3
Number of Residues7
Detailsbinding site for residue EDO J 305
ChainResidue
JHIS29
JASP30
JASN51
JASN52
JMET69
JALA72
JHOH441

site_idAJ4
Number of Residues3
Detailsbinding site for residue EDO J 306
ChainResidue
JARG9
JGLU158
JTYR217

site_idAJ5
Number of Residues6
Detailsbinding site for residue GOL J 307
ChainResidue
AASN86
JASP63
JARG64
JPHE65
JGLN80
JHOH431

site_idAJ6
Number of Residues8
Detailsbinding site for residue PG4 J 308
ChainResidue
ILEU88
IGLY102
ISER103
JGLN37
JTHR38
JMET39
JGLY42
JLEU43

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
ChainResidueDetails
ATYR257-HIS263
BTYR78-HIS84

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
EASN71
FTHR143
FLYS146
FTYR171
JASN71
ATYR84
ATHR143
ALYS146
ATYR171
FTYR7
FTHR73
FTYR84

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
EASN186
JASN186
IASN144
IASN178

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
DASN189
GLYS58
GLYS91
GLYS94
IASN189
BLYS48
BLYS58
BLYS91
BLYS94
GLYS19
GLYS41
GLYS48

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN86
FASN86

218853

PDB entries from 2024-04-24

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