5BZZ

Crystal structure of human phosphatase PTEN in its reduced state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016311	biological_process	dephosphorylation
A	0016791	molecular_function	phosphatase activity
B	0016311	biological_process	dephosphorylation
B	0016791	molecular_function	phosphatase activity
C	0016311	biological_process	dephosphorylation
C	0016791	molecular_function	phosphatase activity
D	0016311	biological_process	dephosphorylation
D	0016791	molecular_function	phosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue TLA A 401

Chain	Residue
A	ASP92
A	HIS93
A	CYS124
A	LYS125
A	ALA126
A	GLY129
A	ARG130
A	GLN171

---

site_id	AC2
Number of Residues	8
Details	binding site for residue TLA B 401

Chain	Residue
B	HIS93
B	CYS124
B	LYS125
B	ALA126
B	GLY129
B	ARG130
B	GLN171
B	ASP92

---

site_id	AC3
Number of Residues	9
Details	binding site for residue TLA C 401

Chain	Residue
C	ASP92
C	HIS93
C	CYS124
C	LYS125
C	ALA126
C	GLY129
C	ARG130
C	GLN171
C	HOH507

---

site_id	AC4
Number of Residues	9
Details	binding site for residue TLA D 401

Chain	Residue
D	ASP92
D	HIS93
D	CYS124
D	LYS125
D	ALA126
D	GLY129
D	ARG130
D	GLN171
D	HOH560

---

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCkaGkgRTG

Chain	Residue	Details
A	ILE122-GLY132

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00590

Chain	Residue	Details
A	CYS124
B	CYS124
C	CYS124
D	CYS124

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08586

Chain	Residue	Details
A	LEU318
B	LEU318
C	LEU318
D	LEU318

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:26166433

Chain	Residue	Details
A	VAL343
A	LEU345
B	VAL343
B	LEU345
C	VAL343
C	LEU345
D	VAL343
D	LEU345

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by FRK => ECO:0000269|PubMed:19345329

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18716620

Chain	Residue	Details
A	LYS313
B	LYS313
C	LYS313
D	LYS313

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 456

Chain	Residue	Details
A	ASP92	proton shuttle (general acid/base)
A	CYS124	covalent catalysis
A	ARG130	transition state stabiliser

---

site_id	MCSA2
Number of Residues	3
Details	M-CSA 456

Chain	Residue	Details
B	ASP92	proton shuttle (general acid/base)
B	CYS124	covalent catalysis
B	ARG130	transition state stabiliser

---

site_id	MCSA3
Number of Residues	3
Details	M-CSA 456

Chain	Residue	Details
C	ASP92	proton shuttle (general acid/base)
C	CYS124	covalent catalysis
C	ARG130	transition state stabiliser

---

site_id	MCSA4
Number of Residues	3
Details	M-CSA 456

Chain	Residue	Details
D	ASP92	proton shuttle (general acid/base)
D	CYS124	covalent catalysis
D	ARG130	transition state stabiliser

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