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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5BZE

Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005540	molecular_function	hyaluronic acid binding
A	0007155	biological_process	cell adhesion
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue DMS A 201

Chain	Residue
A	CYS32
A	ASN89
A	CYS134
A	THR135
A	SER136
A	ARG155
A	ASP156
A	HOH311
A	HOH313

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 202

Chain	Residue
A	ARG33
A	PHE38
A	PHE60
A	ASN125

site_id	AC3
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AC4
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AC5
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AC6
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AC7
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AC8
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AC9
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AD1
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	HOH380
A	HOH389
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376

site_id	AD2
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AD3
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AD4
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AD5
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AD6
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AD7
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AD8
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AD9
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AE1
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AE2
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AE3
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AE4
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AE5
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AE6
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

site_id	AE7
Number of Residues	11
Details	binding site for residues 68N A 203 and 6BT A 204

Chain	Residue
A	ASN29
A	VAL30
A	HIS39
A	GLU41
A	ASP68
A	VAL153
A	ASN154
A	ARG155
A	HOH376
A	HOH380
A	HOH389

Functional Information from PROSITE/UniProt

site_id	PS01241
Number of Residues	45
Details	LINK_1 Link domain signature. CqafnstlptmdqmklAlsk.GfetCryGfiegnvvi.PrihpnaiC

Chain	Residue	Details
A	CYS57-CYS101

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	89
Details	Domain: {"description":"Link","evidences":[{"source":"PROSITE-ProRule","id":"PRU00323","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17293874","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

246704

PDB entries from 2025-12-24

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