Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004707 | molecular_function | MAP kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue 4WE A 401 |
| Chain | Residue |
| A | ILE61 |
| A | MET140 |
| A | ASP143 |
| A | HIS145 |
| A | GLN146 |
| A | SER186 |
| A | LEU189 |
| A | HOH528 |
| A | HOH639 |
| A | GLY62 |
| A | TYR66 |
| A | THR77 |
| A | ALA82 |
| A | LYS84 |
| A | ILE115 |
| A | LEU137 |
| A | ASP138 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | LYS184 |
| A | PRO185 |
| A | SER186 |
| A | HOH527 |
| A | HOH531 |
| A | HOH562 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | PRO153 |
| A | LEU154 |
| A | THR155 |
| A | ARG258 |
| A | ALA291 |
| A | GLU292 |
| A | ARG293 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | GLU192 |
| A | GLU220 |
| A | ARG225 |
| A | ARG228 |
| A | ASN266 |
| A | TYR267 |
| A | HOH518 |
| A | HOH589 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | LEU261 |
| A | VAL277 |
| A | HOH520 |
| A | HOH583 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 406 |
| Chain | Residue |
| A | HIS149 |
| A | ARG258 |
| A | ARG293 |
| A | HOH616 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 407 |
| Chain | Residue |
| A | HIS108 |
| A | TYR172 |
| A | ALA360 |
| A | HOH637 |
| A | HOH686 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGAYGVVSsArrrltgqqv.........AIKK |
| Chain | Residue | Details |
| A | ILE61-LYS85 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDLKpsNLLV |
| Chain | Residue | Details |
| A | VAL178-VAL190 | |
| site_id | PS01351 |
| Number of Residues | 105 |
| Details | MAPK MAP kinase signature. FdvvtnakrtlRElkilkhfkhdniiaikdilrptvpygefksvyvvldlmesdlhqiihssqpltlehvryflyqllrglkymhsaqvih........RDlKpsnllvnenC |
| Chain | Residue | Details |
| A | PHE90-CYS194 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 292 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 61 |
| Details | Region: {"description":"Required for binding to MAP2K5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Motif: {"description":"TXY"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
